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30 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

Applied Public-Private Research enabling OsteoArthritis Clinical Headway (APPROACH)

Date du début: 1 juin 2015, Date de fin: 30 nov. 2020,

The problem: finding the right patient for the right treatmentDespite a large and growing disease burden in osteoarthritis (OA), many pharmaceutical companies have de-emphasized or even abandoned OA drug development due to perceived hurdles. Crucial in this is the lack of appropriate outcome measures that can robustly identify patient benefit from a specific therapy. The lack of specific and sensi ...
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 25

 TERMINÉ 

Clonidine for Sedation of Paediatric Patients in the Intensive Care Unit (CloSed)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,

The majority of critically ill children admitted to Paediatric Intensive Care Units (PICU) will require sedation and analgesia which is commonly achieved with a combination of an benzodiazepine and an opioid. However, these agents have a significant side-effect profile, including tolerance, withdrawal and respiratory/circulatory depression. Clonidine is commonly used for sedation in PICU and recom ...
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 10

 TERMINÉ 

PanCare Studies in Fertility and Ototoxicity to Improve Quality of Life after Cancer during Childhood, Adolescence and Young Adulthood (PANCARELIFE)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Survival rates after childhood cancer now reach nearly 80% in developed European countries as a result of more effective therapies and better supportive care, leading to a steady increase in the number of survivors in the population. However, the treatments that have improved survival are harsh and cause serious side-effects that can greatly impact survivors’ quality of life in the long term. The ...
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 19

 TERMINÉ 

Development and Epilepsy - Strategies for Innovative Research to improve diagnosis, prevention and treatment in children with difficult to treat Epilepsy (DESIRE)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

DESIRE will focus on epileptogenic developmental disorders EDD, i.e. early onset epilepsies whose origin is closely related to developmental brain processes. A major cause of EDD are malformations of cortical development (MCD), either macroscopic or subtle. EDD are often manifested as epileptic encephalopathies (EE), i.e. conditions in which epileptic activity itself may contribute to severe cogni ...
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 29

 TERMINÉ 

EURO EWING Consortium – International Clinical Trials to Improve Survival from Ewing Sarcoma (EEC)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

Ewing Sarcomas (ES) are fatal, rare bone cancers particularly affecting young people. About 60% of patients achieve long term survival with current treatment but there has been no improvement in this proportion for 25 years. Treatment is unsuccessful because chemotherapy fails to prevent the development of, or to effectively treat established, metastases. In addition, of the 600 new cases of ES o ...
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 21

 TERMINÉ 

MicroRNAs in the Pathogenesis, Treatment and Prevention of Epilepsy (EPIMIRNA)

Date du début: 1 sept. 2013, Date de fin: 31 août 2018,

Epilepsy is a major burden for patients and health systems worldwide. It is a common chronic neurological disorder affecting people of all ages, and the shortfall in existing treatments means that 30% of patients continue to suffer uncontrolled seizures. MicroRNAs (miRNA) are a recently-discovered, network-level layer of gene expression regulation that controls protein levels of entire signaling p ...
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 19

 TERMINÉ 

Taking imaging into the therapeutic domain: Self-regulation of brain systems for mental disorders (BRAINTRAIN)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,

Our proposal is based on the idea that real-time functional neuroimaging can be used to train patients to regulate their own brain activity via neurofeedback training and thus modulate the brain networks of mental disorder, restore function, improve symptoms and promote resilience. We have brought together the core groups that have been instrumental in the development of methods for real-time func ...
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 12

 TERMINÉ 

Experience Art - Increase Motivation

Date du début: 1 sept. 2015, Date de fin: 31 août 2017,

The project "Experience Art - Increase Motivation" aims at students in danger of dropping out of school prematurely. We are six schools of upper secondary level from the Czech Republic, France, Germany, Poland, Spain and Turkey. Our aim is to develop and test concepts of increasing the students' motivation by involving them in various art projects. The concepts we want to develop and to test foll ...
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 6

 TERMINÉ 

GAbapentin in Paediatric Pain (GAPP)

Date du début: 1 juil. 2013, Date de fin: 30 juin 2017,

Chronic pain is estimated to affect 15-20% of children with varying disabilities. Due to the paucity of clinical information and appropriate medicinal products, in clinical practice paediatric patients are often under-treated causing profound impact on their QoL.To date, opioids, non-steroid anti-inflammatory drugs (NSAIDs), antidepressants and anticonvulsants are used to treat pain, but only few ...
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 16

 TERMINÉ 

Open Project for the European Radiation Research Area (OPERRA)

Date du début: 1 juin 2013, Date de fin: 31 mai 2017,

"Within the OPERRA project, it is proposed that the MELODI Association, as a well-advanced network, takes the lead in establishing the necessary structures able to manage the long-term European research programmes in radiation protection, also taking advantage of the valuable experience gathered through the DoReMi network of excellence. Whilst in fields adjacent to low-dose risk research (radioeco ...
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 71

 TERMINÉ 

BeTheCuRE (BTCURE)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2017,

BTCure is based on the recognition that RA is a heterogeneous disease where a major subset involves adaptive immunity, and that animal models have to develop the line with the different subsets of the human diseases in order to be optimally used for drug discovery and drug evaluation. Our aim is to develop an understanding of the early process in human arthritis subsets and the animal models that ...
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 41

 TERMINÉ 

European multicentre, randomised, phase III clinical trial of hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke (EuroHYP-1)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2017,

The consortium led by UKER and EuroHYP, the European Stroke Research Network for Hypothermia, proposes a large, multicentre clinical trial which will assess mild hypothermia as a novel treatment for ischemic stroke.Stroke is the second cause of death world-wide and the second cause of lost disability-adjusted life years in high-income countries. Stroke incidence rises exponentially with age, so it ...
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 38

 TERMINÉ 

Towards Early diagnosis and biomarker validation in Arthritis Management (EURO-TEAM)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

An ideal intervention in a chronic inflammatory disease such as Rheumatoid Arthritis (RA) would be a preventive one. In order to develop preventive strategies and therapies two key developments need to occur: (1) Biomarkers need to be identified that can be used to predict an individual’s risk of developing RA. (2) Modifiable disease mechanisms need to be identified and characterized in the early ...
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 17

 TERMINÉ 

DEferiprone Evaluation in Paediatrics (DEEP)

Date du début: 1 janv. 2011, Date de fin: 31 août 2016,

"β-thalassaemia major is one of the most severe forms of chronic congenital anaemia. The recommended treatment consists in regular blood transfusions combined with chelating therapy to remove harmful iron accumulation in the body. The use of deferoxamine, the first chelating agent only available for subcutaneous administration is limited due to toxicity and the lack of compliance, despite its sat ...
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 18

 TERMINÉ 

Europe-Wide Platform for Cooperative Mobility Services (MOBiNET)

Date du début: 1 nov. 2012, Date de fin: 31 août 2016,

MOBiNET will develop, deploy and operate the technical and organisational foundations of an open, multi-vendor platform for Europe-wide mobility services. Key MOBiNET innovations address the barriers to cooperative system-enabled service deployment, including the lack of harmonised services; availability of communication means; inaccessibility and incompatibility of transport-related data; fragmen ...
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 23

 TERMINÉ 

Low Dose Research towards Multidisciplinary Integration (DOREMI)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2015,

The aim of DoReMi is to promote the sustainable integration of low dose risk research in Europe in order to aid the effective resolution of the key policy questions identified by the High Level Expert Group (HLEG) on Low Dose Risk Research (www.hleg.de). DoReMi provides an operational tool for the development of the proposed MELODI platform (Multidisciplinary European Low Dose Risk Re-search Initi ...
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 39

 TERMINÉ 

Pharmacogenomic biomarkers as clinical decision making tools for clozapine treatment of schizophrenia (CRESTAR)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,

Treatment resistant schizophrenia (TRS) is the most disabling of all psychiatric illnesses, affecting about 1/3 of patients (~1 million Europeans), a considerable economic and social burden. First-line treatments include atypical (e.g. olanzapine) and typical (e.g. haloperidol) antipsychotics. The original atypical, clozapine, is a final option, and although it is the only antipsychotic shown to b ...
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 11

 TERMINÉ 

Integrated software platform for Green ENgineering dESIgn and product sustainability (G.EN.ESI)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2015,

The project (36 months long) aims at developing a software engineering platform, called G.EN.ESI for eco-design and product sustainability of electronic and mechatronic products. G.EN.ESI is realized through a set of new tools that support designers’ choices from an environmental point of view. These tools allow to evaluate technical solutions in the early design phases and their impact on the who ...
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 8

 TERMINÉ 

Ecological Function and Biodiversity Indicators in European Soils (ECOFINDERS)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2014,

The strategic goal of EcoFINDERS is to provide the EC with tools to design and implement soil strategies aimed at ensuring sustainable use of soils, including: i) Characterisation of European soil biodiversity; ii) Determination of relations between soil biodiversity, soil functions and ecosystem services; iii) Design of policy-relevant and cost-effective indicators for monitoring soil biodiversit ...
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 29

 TERMINÉ 

Systems biology towards novel chronic kidney disease diagnosis and treatment (SysKID)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2014,

Chronic kidney disease (CKD) affects up to 10% of the population. Besides eventual progression towards end stage renal disease CKD impacts the patient’s quality of life by causing serious comorbidities including cardiovascular complications and bone metabolism disorders. On the everyday clinical level early stage diagnosis and tailored treatment of CKD are still inadequate. In addition, CKD seems ...
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 30

 TERMINÉ 

Intelligent Knowledge Platform for Personal Health Monitoring Services (eHealthMonitor)

Date du début: 1 déc. 2011, Date de fin: 30 nov. 2014,

The eHealthMonitor project provides a platform that generates a Personal eHealth Knowledge Space (PeKS) as an aggregation of all knowledge sources (e.g., EHR and PHR) relevant for the provision of individualized personal eHealth services. This is realised by integrating service-oriented architecture, knowledge engineering, multiagent systems, and wearable/portable devices technologies. Innovations ...
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 11

 TERMINÉ 

Persistence of allergic sensitization (PAS)

Date du début: 1 déc. 2009, Date de fin: 30 nov. 2014,

"Allergic disorders are dramatically increasing in the western world over the past several years. Allergies are inappropriate immune responses directed against harmless environmental antigens. Upon primary allergen encounter B cells are induced to differentiate into IgE producing plasma cells. Mast cells and basophils are then sensitized by binding of allergen-specific IgE molecules to the high-af ...
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 2

 TERMINÉ 

Influence of protein prenylation and its modulation on the immune system (Pren-IBD)

Date du début: 1 août 2012, Date de fin: 31 juil. 2014,

Prenylation is a postranslational process leading to changes in protein structure due to the incorporation of a lipidic moiety that significantly modifies their physicochemical properties and their behaviour. Prenylation is therefore a crucial step for key cell processes, such as interaction between proteins, cell and differentiation, cytoskeletal function and vesicular trafficking. The modificati ...
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 1

 TERMINÉ 

ADIPOSE DERIVED STROMAL CELLS FOR OSTEOARTHRITIS (ADIPOA)

Date du début: 1 janv. 2010, Date de fin: 30 juin 2014,

Osteoarthritis (OA) is a degenerative joint disease for which no efficient therapy is available. The ADIPOA consortium has previously shown that intraarticular injections of stromal cells prevents OA in two different models, but the mechanisms of this chondroprotective effect remains unknown, and the activation of cartilage derived endogenous stem cells is suspected. The participants have experien ...
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 12

 TERMINÉ 

Enhanced Design Requirements and Testing Procedures for Composite Cylinders intended for the Safe Storage of Hydrogen (HyCOMP)

Date du début: 1 janv. 2011, Date de fin: 31 mars 2014,

Hydrogen storage is a key enabling technology for the use of hydrogen as an energy vector. To improve volumetric and gravimetric performance, carbon fiber composite cylinders are currently being developed. However, current standards governing the design, qualification and in-service inspection of carbon fiber composite cylinders do not allow cylinder design to be optimized. In particular, safet ...
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 12

 TERMINÉ 

Best-Reliable Ambient Intelligent Nano Sensor Systems (e-BRAINS)

Date du début: 1 sept. 2010, Date de fin: 28 févr. 2014,

Best-Reliable Ambient Intelligent Nanosensor Systems – e-BRAINS – represent a giant leap for outstanding future applications in the area of ambient living with the ultimate need for integration of heterogeneous technologies, high-performance nanosensor devices, miniaturization, smart wireless communication and best-reliability.e-BRAINS with minimum volume and weight as well as reduced power consum ...
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 20

 TERMINÉ 

Discovery and preclinical development of new generation tuberculosis vaccines (NEWTBVAC)

Date du début: 1 janv. 2010, Date de fin: 28 févr. 2014,

"With 14.4 million prevalent cases and 1.7 million deaths tuberculosis (TB) remains one of the most serious infectious diseases to date. An estimated 2 billion people are believed to be infected with Mycobacterium tuberculosis and at risk of developing disease. Multi- and extensively drug resistant strains are increasingly appearing in many parts of the world, including Europe. While with current ...
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 39

 TERMINÉ 

European Network for Cell Imaging and Tracking Expertise (ENCITE)

Date du début: 1 juin 2008, Date de fin: 30 nov. 2012,

"Cell therapy can be defined as the transplantation of living cells for the treatment of medical disorders. Three different principles underlie the increasing interest in cell therapy. 1. Transplanted cells used as an “active drug” 2. Transplanted cells used to replace damaged and degenerated tissue. 3. Cells used as a drug delivery vehicle. Promising results have been obtained in pre-clinical and ...
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 30

 TERMINÉ 

SMART HOMES FOR ALL. AN EMBEDDED MIDDLEWARE PLATFORM FOR PERVASIVE AND IMMERSIVE ENVIRONMENTS FOR-ALL (SM4All)

Date du début: 1 sept. 2008, Date de fin: 31 août 2011,

Embedded systems are specialised computers used in larger systems or machines to control equipments such as automobiles, home appliances, communication, control and office machines. Such pervasivity is particularly evident in immersive realities, i.e., scenarios in which invisible embedded systems need to continuosly interact with human users, in order to provide continuous sensed information and ...
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 12

 TERMINÉ 

Genomic instability and genomic alterations in pre-cancerous lesions and/or cancer (GENINCA)

Date du début: 1 janv. 2008, Date de fin: 30 juin 2011,

"GENINCA will address two tumor entities, for which we have good access to pre-malignant lesions and in which genomic instability is a common feature: colorectal and liver cancer. Colorectal cancer amounts to 13.2% of all incident cases of cancer, the second most common form of cancer, surpassed only by lung cancer (13.3%). Liver cancer accounts for about 2% of total cancers, however, the most com ...
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 14