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Plus de 40 projets européens trouvés

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 TERMINÉ 

Bond activation and catalysis with low-valent aluminium (AlCat)

Date du début: 1 mars 2017, Date de fin: 28 févr. 2022,

This project will develop the principles required to enable bond-modifying redox catalysis based on aluminium by preparing and studying new Al(I) compounds capable of reversible oxidative addition.Catalytic processes are involved in the synthesis of 75 % of all industrially produced chemicals, but most catalysts involved are based on precious metals such as rhodium, palladium or platinum. These me ...
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 1

 TERMINÉ 

Development of Effective Vaccines against Multiple Lifecycle Stages of Plasmodium vivax malaria (MultiViVax)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Plasmodium vivax is the most widespread malaria and constitutes a significant proportion of human malaria cases. P. vivax accounts for 100-400 million clinical cases each year among the 2.5 billion people living at risk in Latin America, Oceania and Asia. The recently revised Malaria Vaccine Technology Roadmap to 2030 recognises the severity of P. vivax malaria and calls for a vaccine intervention ...
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 9

 TERMINÉ 

QCD for the Future of Particle Physics (QCDforfuture)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

The momentous discovery of the Higgs boson in 2012 marked the start of a new era in particle physics. The increase in energy of collisions at the Large Hadron Collider (LHC) this year allows us to probe fundamental physics at an energy scale which has been out of reach until now. This presents a challenge to particle theory to keep pace with these developments, and respond to the fact that Stand ...
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 1

 TERMINÉ 

An integrated approach to understanding the impact of de novo mutations on the mammalian genome (DENOVOMUT)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Understanding the process of spontaneous mutation is fundamental for understanding the genetic basis of quantitative variation, the threat posed by declining population size in conservation biology and the distribution of nucleotide variation in the genome. I will address these and other unanswered questions concerning the evolutionary impact of spontaneous mutation using the house mouse as a mode ...
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 2

 TERMINÉ 

A Global Anthropology of Transforming Marriage (AGATM)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

This research will create a new theoretical vision of the importance of marriage as an agent of transformation in human sociality. Marriage globally is undergoing profound change, provoking intense debate and anxiety. These concerns refract wider instabilities in political, economic, and familial institutions. They signal the critical role of marriage in bringing together - and separating - intima ...
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 1

 TERMINÉ 

Imaging synaptic contributors to dementia (ALZSYN)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2021,

Alzheimer's disease, the most common cause of dementia in older people, is a devastating condition that is becoming a public health crisis as our population ages. Despite great progress recently in Alzheimer’s disease research, we have no disease modifying drugs and a decade with a 99.6% failure rate of clinical trials attempting to treat the disease. This project aims to develop relevant therap ...
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 1

 TERMINÉ 

Hydrogen at Extreme Conditions: Applying Theory to Experiment for creation, verification and understanding (HECATE)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,

Hydrogen is the simplest and most abundant element in the universe. It exists under extreme conditions in stars and planets. Nuclear fusion, requires creating such extreme temperature and pressure on earth. Lightweight storage of hydrogen in condensed form would unleash its potential as a fuel. The behaviour of a collection of protons and electrons presents an iconic challenge in fundamental phy ...
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 1

 TERMINÉ 

Medical translation in the history of modern genomics (TRANSGENE)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,

The translation of basic biomedical research into clinical practice has become a central concern for science policy. Policies to foster translation are being applied to large amounts of genomic information available in open-access databases. This information is the result of concerted initiatives that, in the early 2000s, determined the full genetic sequence that characterises humans and other org ...
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 1

 TERMINÉ 

International Master of Science in Infectious Diseases and One Health

Date du début: 5 sept. 2016, Date de fin: 5 sept. 2021,

... is a two-year (120 ECTS) joint master degree taught in English and awarded by three European universities (Université de Tours - France, Universitat Autònoma de Barcelona - Spain and University of Edinburgh - UK). The three universities work in very close collaboration with worldwide recognized research institutes and centers: INRA, CreSA-IRTA and the Roslin Institute. The IDOH consortium also in ...
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 3

 TERMINÉ 

A programming language bridging theory and practice for scientific data curation (Skye)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

...ta sharing. There are hundreds of curated scientific databases in biomedicine that need fine-grained provenance; one important example is GtoPdb, a pharmacological database developed by colleagues in Edinburgh. Currently there are no reusable methodologies or practical tools that support provenance for curated databases, forcing each project to start from scratch. Research on provenance for scient ...
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 1

 TERMINÉ 

Translating from Multiple Modalities into Text (TransModal)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

Recent years have witnessed the development of a wide range of computational methods that process and generate natural language text. Many of these have become familiar to mainstream computer users such as tools that retrieve documents matching a query, perform sentiment analysis, and translate between languages. Systems like Google Translate can instantly translate between any pair of over fifty ...
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 1

 TERMINÉ 

Exploiting low dimensional models in sensing, computation and signal processing (C-SENSE)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

The aim of this project is to develop the next generation of compressive and computational sensing and processing techniques. The ability to identify and exploit good signal representations is pivotal in many signal and data processing tasks. During the last decade sparse representations have provided stunning performance gains for applications such as: imaging coding, computer vision, super-resol ...
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 1

 TERMINÉ 

The evolution of linguistic complexity (ELC)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

Human language is unique among the communication systems of the natural world, providing our species with an incredibly flexible and powerful open-ended system of communication. This expressive power is underpinned by linguistic structure: we construct complex meaning-bearing utterances according to a set of rules and regularities which are conventionalised among speakers of a language. In my prev ...
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 1

 TERMINÉ 

Marine Renewable Infrastructure Network for Enhancing Technologies 2 (MARINET2)

Date du début: 1 janv. 2017, Date de fin: 30 juin 2021,

Integrating activities planned under MaRINET 2 build upon the achievements of the advanced community created in MaRINET FP7. MaRINET 2 will ensure the continued integration and enhancement of all leading European research infrastructure and facilities specialising in research, development and testing of offshore renewable energy systems including electrical sub systems and grid integration through ...
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 39

 TERMINÉ 

Genetic Determinants of the Epigenome (Gen-Epix)

Date du début: 1 juin 2016, Date de fin: 31 mai 2021,

Decoding of the genome during development and differentiation depends on sequence-specific DNA binding proteins that regulate transcription. The activity of transcription factors is constrained, however, by chromatin structure and by modification of histones and DNA, known collectively as the “epigenome”. Diseased states, particularly cancers, are often accompanied by epigenomic disturbances that ...
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 1

 TERMINÉ 

The physics of antibiotic resistance evolution in spatially-structured multicellular assemblies (EvoStruc)

Date du début: 1 juin 2016, Date de fin: 31 mai 2021,

The rise in bacterial infections that are resistant to antibiotic treatment poses a major global health challenge. Addressing this challenge is not just a clinical issue: understanding bacterial resistance evolution calls for an interdisciplinary approach, in which the development of new physics, in coordination with biology, chemistry and engineering, has a central role to play. In particular, st ...
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 1

 TERMINÉ 

Direct measurements of key nuclear Reactions for the creation of Elements in Stars (DoRES)

Date du début: 1 juin 2016, Date de fin: 31 mai 2021,

The evolution of the universe has left an imprint in the form of the chemical elements. Understanding the cosmic origins of the elements remains a major challenge for science. The abundances of elements we see in our solar system, distant stars, meteorites, and in stellar explosions provide us with clues about how the elements came to be produced in a variety of different processes and stellar env ...
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 1

 TERMINÉ 

Establishing genetic code expansion as a tool to study neuronal circuit function in an animal (UAAWORM)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2021,

We work at the intersection of synthetic multicellular biology and organismal neurobiology. We pioneered technologies that allow the site-specific introduction of chemically synthesized unnatural amino acids (UAA) into a chosen protein within the context of a multicellular organism - the nematode worm C. elegans. The foundational technology for this advance is genetic code expansion. In its most s ...
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 1

 TERMINÉ 

BIOlogical therapy CYCLEs towards tailored, needs-driven, safer and cost-effective management of Crohn’s disease (BIOCYCLE)

Date du début: 1 avr. 2015, Date de fin: 31 mars 2021,

"The BIOCYCLE Project proposes to test and critically assess the benefits and risks of an innovative regimen for improving the treatment of Crohn’s disease (CD), a chronic immune-mediated inflammatory disease affecting the gastro-intestinal tract of an increasing number of patients. Currently, the combination of anti-TNFα monoclonal antibodies and immunosuppressants used without interruption is th ...
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 13

 TERMINÉ 

Proteasome-Mediated Gene Expression in Plant Immunity (IMMUNE-EXPRESS)

Date du début: 1 mars 2016, Date de fin: 28 févr. 2021,

Plants are continuously exposed to a wide variety of pathogenic attackers that cause major crop losses to agriculture worldwide. Unlike vertebrates that use specialized immune cells to detect non-self, each individual plant cell is thought to be capable of launching an effective immune response. Plant immune responses are largely orchestrated by the immune hormone, salicylic acid (SA), which accum ...
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 1

 TERMINÉ 

Strengthening European Food Chain Sustainability by Quality and Procurement Policy (Strength2Food)

Date du début: 1 mars 2016, Date de fin: 28 févr. 2021,

Strength2Food is a 5-year, €6.9 million project to improve the effectiveness of EU food quality schemes (FQS), public sector food procurement (PSFP) and to stimulate Short Food Supply Chains (SFSC) through research, innovation and demonstration activities. Our 30-partner consortium representing 11 EU and 4 non-EU countries combines leading academic, communication, SME and stakeholder organisations ...
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 31

 TERMINÉ 

Expecting Ourselves: Embodied Prediction and the Construction of Conscious Experience (XSPECT)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

This project (short name, XSPECT) aims to harness the emerging science of the predictive brain to deliver new insights into the nature, scope, mechanisms and (most importantly) the very possibility of conscious experience. The project thus explores and extends the vision of the brain as an inner engine continuously striving to predict the incoming sensory barrage. The key innovation is to consider ...
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 2

 TERMINÉ 

Evolutionary genomics: new perspectives and novel medical applications (EvoGenMed)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

To make for better diagnostics and safer applications of genomics we need a better understanding of our genome and how it functions. Until recently we thought we knew: intergenic sequence must be largely “junk” and mutations that, for example, affect genes but not the protein (synonymous mutations) must be effectively neutral. This degenerate genome view accords with the nearly-neutral theory’s pr ...
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 3

 TERMINÉ 

Perspectival Realism. Science, Knowledge, and Truth from a Human Vantage Point (Perspectival Realism)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

This project develops a novel view in philosophy of science called perspectival realism, via a three-pronged highly interdisciplinary approach, which combines the philosophy of science, with scientific practice, the history of science and the history of philosophy. Scientific perspectivism has recently attracted a great deal of attention for its ability to account for the perspectival nature of mo ...
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 1

 TERMINÉ 

Small vessel diseases in a mechanistic perspective: Targets for InterventionAffected pathways and mechanistic exploitation for prevention of stroke and dementia (SVDs-at-target)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Stroke and dementia rank among the most pressing health issues in Europe. Cerebral small vessel diseases (SVDs) have emerged as a central link between these two major co-morbidities. SVDs account for more than 30% of strokes and at least 40% of dementia cases. They encounter multiple distinct diseases that can be separated based on their underlying genetic defects, risk factors, and clinical prese ...
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 14

 TERMINÉ 

INtestinal Tissue ENgineering Solution (INTENS)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Short Bowel Syndrome (SBS) is a condition that occurs when part or the entire small intestine is missing or has been removed during surgery. This condition renders the bowel incapable of fulfilling its nutritional function (intestinal failure). There is no cure for SBS. Parenteral (intravenous) nutrition (PN) and bowel transplantation are currently the preferred options for nutrition in children a ...
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 9

 TERMINÉ 

African Governance and Space: Transport Corridors, Border Towns and Port Cities in Transition (AFRIGOS)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

AFRIGOS investigates the process of 'respacing' Africa, a political drive towards regional and continental integration, on the one hand, and the re-casting of Africa's engagement with the global economy, on the other. This is reflected in unprecedented levels of investment in physical and communications infrastructure, and the outsourcing of key functions of Customs, Immigration and security agenc ...
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 1

 TERMINÉ 

Global Lensing Observations to go Beyond Einstein (GLOBE)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2020,

This ERC Consolidator grant will push forward the boundaries in our understanding of gravity by confronting the most advanced theoretical framework for modified gravity models with this decade’s ultimate set of observations. Using three state-of-the-art, same-sky lensing spectroscopy surveys, which are the only deep surveys currently in existence to have this unique complementarity, we will under ...
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 1

 TERMINÉ 

Resource Bounded Graph Query Answering (GRACE)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2020,

When we search for a product, can we find, using a single query, top choices ranked by Google and at the same time, recommended by our friends connected on Facebook? Is such a query tractable on the social graph of Facebook, which has over 1.31 billion nodes and 170 billion links? Is it feasible to evaluate such a query if we have bounded resources such as time and computing facilities? These ques ...
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 1

 TERMINÉ 

Advanced Carbon Materials from Biowaste: Sustainable Pathways to Drive Innovative Green Technologies (GreenCarbon)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2020,

The energy crisis, environmental pollution and global warming are serious problems that are of great concern throughout the world. Around 40% of the world’s energy consumption is dedicated to the production of materials and chemicals. Thus, there is a need to develop high-performance materials based on renewable resources, simpler to synthesise and cost effective. Carbon materials derived from ren ...
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 10

 TERMINÉ 

Enriched communication across the lifespan (ENRICH)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2020,

"Speech is a hugely efficient means of communication: a reduced capacity in listening or speaking creates a significant barrier to social inclusion at all points through the lifespan, in education, work and at home. Hearing aids and speech synthesis can help address this reduced capacity but their use imposes greater listener effort. The fundamental objective of the ETN "Enriched communication acr ...
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 8

 TERMINÉ 

Chemical Biology in Zebrafish: Drug-Leads and New Targets in the Melanocyte Lineage and Melanoma (ZF-MEL-CHEMBIO)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Melanoma (cancer of the melanocyte) kills over 20,000 Europeans each year and incidence continues to rise rapidly. BRAF(V600E) inhibitors have led to clinically significant improvements in outcomes for melanoma patients, yet many patients with metastatic melanoma rapidly succumb to the disease due to eventual chemoresistance, or insensitivity to the drug. Thus, it is critical to identify new thera ...
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 1

 TERMINÉ 

Evolutionary genetics of guppy sex chromosomes (GUPPYSEX)

Date du début: 1 août 2016, Date de fin: 31 juil. 2020,

I propose an integrated programme of molecular genetic studies to fill fundamental gaps in our knowledge of sex chromosome evolution. Specifically, I will use a fish, the guppy (Poecilia reticulata), to test the sexual antagonism (SA) hypothesis of sex chromosome evolution, which is plausible, but lacks direct evidence. SA mutations (that benefit one sex but lower fitness of the other) are propose ...
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 2

 TERMINÉ 

Molecular organization and dynamics of synapse diversity: novel genetic, imaging and computational approaches (SYNNOVATE)

Date du début: 1 août 2016, Date de fin: 31 juil. 2020,

Synapses are a hallmark of the brain, showing remarkable anatomical and molecular complexity, and central to the aetiology and progression of hundreds of brain diseases. The vertebrate brain has a vast potential synapse diversity arising from the differential distribution of combinations of proteins into individual synapses. This has led to the recognition that “synaptome mapping” needs to be deve ...
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 1

 TERMINÉ 

A Comparative Anthropology of Conscience, Ethics and Human Rights (AnCon)

Date du début: 1 août 2015, Date de fin: 31 juil. 2020,

This project is a comparative anthropology of conscience, ethics and human rights. Numerous international human rights documents formally declare their commitment to protect freedom of conscience. But, what is conscience and how do we know it when we see it? How do we distinguish it from self-interest or fanaticism? And what happens when the concept, often associated with a distinct Christian or l ...
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 2

 TERMINÉ 

iABC Programme (IABC PROGRAMME)

Date du début: 1 août 2015, Date de fin: 31 juil. 2020,

Cystic Fibrosis (CF) is a common fatal inherited disease with a frequency of 1 in 2500 live births, affecting approximately 36,000 (0.737/10,000) people in the EU. Chronic bacterial pulmonary infection leading to an irreversible decline in lung structure and function is the main cause of mortality and morbidity in patients with CF, with more than 95% of deaths due to respiratory failure. Pseudomon ...
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 21

 TERMINÉ 

The artificial pancreas in children aged 1 to 7 years with type 1 diabetes (KidsAP)

Date du début: 1 janv. 2017, Date de fin: 30 juin 2020,

TYPE 1 DIABETES is one of the most COMMON CHRONIC diseases in children with a RAPID increase in number of cases particularly in young children. Type 1 diabetes is associated with LIFE-LONG dependency on insulin administration. POOR glucose control leads to diabetes COMPLICATIONS, e.g. eye, heart, kidney disease, including BRAIN changes in young children. Episodes of VERY LOW glucose levels may be ...
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 14

 TERMINÉ 

The physics of three dimensional chromosome and protein organisation within the cell (THREEDCELLPHYSICS)

Date du début: 1 juil. 2015, Date de fin: 30 juin 2020,

Understanding the fundamental mechanisms behind the functioning of cells and their interior has long been a biology-only enterprise. This view has radically changed in the last decade or so, culminating in the invention of a whole new field, named 'cell physics', which uses the tools of physics to gain a more quantitative and deeper understanding of the inner working of a cell. The aim of my resea ...
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 1

 TERMINÉ 

The Quantum Geometric Langlands Topological Field Theory (QuantGeomLangTFT)

Date du début: 1 juin 2015, Date de fin: 31 mai 2020,

We will use modern techniques in derived algebraic geometry, topological field theory and quantum groups to construct quantizations of character varieties, moduli spaces parameterizing G-bundles with flat connection on a surface. We will leverage our construction to shine new light on the geometric representation theory of quantum groups and double affine Hecke algebras (DAHA's), and to produce n ...
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 1

 TERMINÉ 

Exploring Thermodynamic Properties of Earth’s Core-Forming Materials (Earth core)

Date du début: 1 juin 2015, Date de fin: 31 mai 2020,

It is known that the Earth’s core is less dense than pure iron by about 7%, which is due to the presence of a light element(s) such as Si, S, C, O, and H. The goal of this project is to construct a thermodynamic model of the Earth’s central core. A particular focus is on the identification of the light element because the inclusion of these elements in iron liquid depends on the pressure (P), temp ...
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 1