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37 projets européens trouvés

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 TERMINÉ 

Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI)

Date du début: 1 oct. 2013, Date de fin: 31 mars 2020,

Traumatic Brain Injury (TBI) is a major cause of death and disability, leading to great personal suffering to victim and relatives, as well as huge direct and indirect costs to society. Strong ethical, medical, social and health economic reasons therefore exist for improving treatment. The CENTER-TBI project will collect a prospective, contemporary, highly granular, observational dataset of 5400 p ...
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 44

 TERMINÉ 

Combination therapies for personalized cancer medicine (COMBATCANCER)

Date du début: 1 mai 2013, Date de fin: 30 avr. 2019,

All cancers arise due to alterations in their genomes. Although insight into the genetic lesions in tumours by genome sequencing does already assist in selecting some drug regimens, it rarely results in disease eradication due to the emergence of drug-resistant clones. More sophisticated combination therapies in which several oncogenic pathways are targeted simultaneously or in a particular seque ...
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 2

 TERMINÉ 

Sequencing population isolates to find complex trait loci (SEPI)

Date du début: 1 juin 2012, Date de fin: 31 mai 2017,

"Genome-wide association studies of complex traits have identified many common variant associations, but a substantial heritability gap remains. The field is shifting towards the study of low frequency and rare variants, hypothesised to have larger effects. The study of these variants can be empowered by focusing on isolated populations, in which rare variants may have increased in frequency and l ...
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 1

 TERMINÉ 

Vaccination against Shigella and ETEC: novel antigens, novel approaches (STOPENTERICS)

Date du début: 1 nov. 2010, Date de fin: 30 avr. 2017,

To contribute to the development of vaccines against Shigella and ETEC for children of the developing world, STOPENTERICS will provide novel solutions by imposing a two-fold paradigm switch: (i) to break the dogma of serotype-specificity by inducing a cross-protective immunity (ii) to improve the immunogenicity of Shigella glycoconjugates by using synthetic oligosacharides mimicking the lipopolysa ...
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 20

 TERMINÉ 

Mechanisms and Treatment of Migraine and its Chronification (EUROHEADPAIN)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2017,

Migraine is a common brain disorder, typically characterised by recurring, incapacitating attacks of 1-3 days of severe headache, autonomic dysfunction, and sometimes aura symptoms. The disease affects 15% of all European citizens including children, ranks among the WHO top 12 of most disabling and undertreated disorders, and is responsible for the highest socio-economic burden of any brain ailmen ...
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 14

 TERMINÉ 

BBMRI - Large Prospective Cohorts (BBMRI-LPC)

Date du début: 1 févr. 2013, Date de fin: 31 janv. 2017,

In recent years, biomedical research has crossed international borders in large, collaborative studies showing the value of multidisciplinarity and scale advantage. This has yielded valuable insights and some led to new and better medicines and treatments for diseases. However, disease-focused studies provide less insight in the real disease onset, the relative disease burden in the population, an ...
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 36

 TERMINÉ 

Development of mouse mutant resources for functional analyses of human diseases - Enhancing the translation of research into innovation (INFRAFRONTIER-I3)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,

The mouse shows great similarities in development, physiology and biochemistry to humans, which makes it a key model for research into human disease. The major challenges for mouse functional genomics in the 21st century are to:• Develop a series of mutant alleles for every gene in the mouse genome• Determine the phenotypic consequences of each mutation• Identify mouse models for the complete dise ...
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 24

 TERMINÉ 

Testing and validation of bispecific antibody combinations targeting treatment-resistant cancer stem cells using organoid-based screening tools: a new drug discovery paradigm (SUPPRESSTEM)

Date du début: 1 juin 2013, Date de fin: 30 nov. 2016,

Colorectal cancer (CRC) was diagnosed in 1.23 million people worldwide (EU 333,000) in 2008 and 608,000 (EU 148,000) died of the disease. While some new treatments have been advanced in CRC many have failed clinical testing; metastatic CRC is still largely incurable.In CRC, Cancer Stem Cells (CSC) are responsible for tumour progression and resistant to standard chemotherapies. The Wnt signal trans ...
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 5

 TERMINÉ 

Genetic studies of pre-eclampsia in Central Asian and European populations (INTERPREGGEN)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2016,

Pre-eclampsia, one of the most dangerous cardiometabolic complications of pregnancy, claims the lives of 50,000 mothers and almost one million babies annually. Pre-eclampsia and other hypertensive disorders of pregnancy remain the second most common cause of maternal death. The incidence of pre-eclampsia in Central Asian countries is over twice as high as in western Europe. Inter-population differ ...
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 13

 TERMINÉ 

A BLUEPRINT of Haematopoietic Epigenomes (BLUEPRINT)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2016,

In response to the call for a high impact initiative on the human epigenome, the BLUEPRINT Consortium has been formed with the aim of generating at least 100 reference epigenomes and studying them to advance and exploit knowledge of the underlying biological processes and mechanisms in health and disease. BLUEPRINT will focus on distinct types of haematopoietic cells from healthy individuals and o ...
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 45

 TERMINÉ 

Identification of drug-resistance genes for the development of effective combined therapies for melanoma (MELANOMA DRUG RESIST)

Date du début: 1 juil. 2014, Date de fin: 30 juin 2016,

Malignant melanoma is a highly aggressive form of skin cancer with a poor outcome following metastatic spread. Chemotherapies for metastatic melanoma are rarely curative because of the emergence of clones from within the tumor that carry lesions in genes that confer therapeutic resistance. Understanding the genetic culprits of drug resistance will allow the rationale development of combination the ...
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 1

 TERMINÉ 

Graphene-Based Revolutions in ICT And Beyond (GRAPHENE)

Date du début: 1 oct. 2013, Date de fin: 31 mars 2016,

This Flagship aims to take graphene and related layered materials from a state of raw potential to a point where they can revolutionize multiple industries – from flexible, wearable and transparent electronics, to new energy applications and novel functional composites.Our main scientific and technological objectives in the different tiers of the value chain are to develop material technologies fo ...
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 154

 TERMINÉ 

Epigenetics towards systems biology (EPIGENESYS)

Date du début: 1 oct. 2010, Date de fin: 31 mars 2016,

The ‘EpiGeneSys’ Network of Excellence aims to enable European epigenetics research to enter the arena of systems biology, a new step forward with major implications for human health. Many diseases, not explained solely by gene mutation, have rather been associated with epigenetic disorders. Following the identification of key epigenetic regulators, a move towards a systems biology approach is nee ...
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 28

 TERMINÉ 

Zebrafish Regulomics for Human Health (ZF-HEALTH)

Date du début: 1 juil. 2010, Date de fin: 31 déc. 2015,

In recent years, the zebrafish has emerged as a new vertebrate model organism for biomedical research which offers a unique combination of traits: a short generation time, small size and efficient breeding procedures make it the best choice among vertebrates for forward genetic screening and small-molecule screens, including toxicology, while the transparent embryo and larva offers unique opportun ...
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 20

 TERMINÉ 

European Network of HIV/AIDS Cohort Studies to Coordinate at European and International Level Clinical Research on HIV/AIDS (EuroCoord)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,

Over the past 15 years, EU-funded cohorts and collaborations (EuroSIDA, CASCADE and PENTA), have played a central role in developing our understanding of HIV progression and the effects of ART, enabling European expertise to contribute directly to the advances in patient diagnosis and management worldwide, and providing a continued surveillance mechanism for detection of emerging problems at a Eur ...
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 26

 TERMINÉ 

Systems Biology of Stem Cells and Reprogramming (SyBoSS)

Date du début: 1 juin 2010, Date de fin: 30 nov. 2015,

Stem cells are central to emerging concepts in health, medicine and therapy. The realization that specific cell reservoirs retain multipotency for tissue establishment and replenishment has implications for both the emerging field of regenerative therapy and the long standing problems of cancer, ageing and degenerative diseases. Recently the prospects for regenerative therapy have been boosted by ...
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 11

 TERMINÉ 

European Sequencing and Genotyping Infrastructure (ESGI)

Date du début: 1 févr. 2011, Date de fin: 31 juil. 2015,

The objective of this project is the integration of world class high-throughput sequencing and genotyping facilities that will provide sequencing and genotyping technologies and data analysis methodologies to the scientific community.The European Sequencing and Genotyping Infrastructure (ESGI) will enable external users to generate data rapidly and to acquire knowledge efficiently. By providing ac ...
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 11

 TERMINÉ 

Genetic and Epigenetic Networks in Cognitive Dysfunction (GENCODYS)

Date du début: 1 mai 2010, Date de fin: 30 avr. 2015,

Mutations in about 400 different genes have been associated with Cognitive Disorders (CD), such as mental retardation, autism, neurodegenerative disorders, and psychiatric disorders. Whereas CD impose a major medical and socio-economical problem, there are no systematic studies that aim to provide insight into common mechanisms in CD. We propose a systems biology approach to gain insight into comm ...
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 15

 TERMINÉ 

Towards the establishment of a permanent European Virtual Institute dedicated to Malaria Research (EVIMalaR) (EVIMalaR)

Date du début: 1 oct. 2009, Date de fin: 31 mars 2015,

This is a proposal from 55 partners from 36 institutes to form a NoE that will seek to integrate European malaria research that is directed towards a better understanding of the basic biology of the parasite, its vector and of the biology of the interactions between the parasite and both its mammalian host and vectors. All the member institutes and researchers have demonstrated both their excellen ...
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 40

 TERMINÉ 

European Consortium on Synaptic Protein Networks in Neurological and Psychiatric Diseases (EUROSPIN)

Date du début: 1 janv. 2010, Date de fin: 30 juin 2014,

"Signalling at nerve cell synapses - a key determinant of all aspects of brain function - depends on the function of hundreds of synaptic proteins and their interactions. Numerous recent studies showed that a wide range of neurological and psychiatric diseases are 'synaptopathies' whose onset and progression are due to mutations of synaptic proteins and subsequent synaptic dysfunctions. EUROSPIN w ...
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 19

 TERMINÉ 

European Management Platform for Emerging and Re-emerging Infectious disease Entities (EMPERIE)

Date du début: 1 mai 2009, Date de fin: 30 avr. 2014,

"The EMPERIE (European Management Platform for Emerging and Re-emerging Infectious disease Entities) consortium has its roots in the lessons learned by the majority of the participating centres during the recent SARS and HPAI H5N1 outbreaks. The mission of EMPERIE is “to contribute to effectively countering the potential public health threat caused by new and emerging infectious diseases in Europe ...
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 12

 TERMINÉ 

Gene Discovery in Melanoma Progression and Therapeutic Resistance (Melanoma Genes)

Date du début: 15 avr. 2012, Date de fin: 14 avr. 2014,

Melanoma is among the most common and deadly human cancers. It kills more than 2000 people in the UK every year but an effective cure for metastatic disease does not exist yet.The mutation of valine to glutamic acid at position 600 (V600E) of the BRAF kinase is found in over 60% of human melanomas, establishing it as a prominent oncogene in melanoma. Since this mutation is also commonly identified ...
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 2

 TERMINÉ 

The molecular regulation of T helper cell subtype plasticity (ThPLAST)

Date du début: 8 août 2011, Date de fin: 4 févr. 2014,

Naïve CD4+ T cell differentiate into distinct lineages to achieve successful adaptive immune responses to diverse categories of pathogens. The development of these effector cells is controlled by cytokines, transcription factor interactions and chromatin modifications. In addition, several of the differentiated subtypes can interconvert, a property known as plasticity. However, the molecular regu ...
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 2

 TERMINÉ 

Sharing capacity across Europe in high-throughput sequencing technology to explore genetic variation in health and disease (GEUVADIS)

Date du début: 1 oct. 2010, Date de fin: 31 déc. 2013,

"High-throughput next-generation DNA sequencing technologies allow investigators to sequence entire human genomes at an affordable price and within a short time frame. The correct interpretation, storage, and dissemination of the large amount of produced genomics data generate major challenges. Tackling these challenges requires extensive exchange of data, information and knowledge between medical ...
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 17

 TERMINÉ 

The Microme Project: A Knowledge-Based Bioinformatics Framework for Microbial Pathway Genomics (Microme)

Date du début: 1 déc. 2009, Date de fin: 30 nov. 2013,

The exponential increase in microbial genome and metagenome sequencing throughput has widened the gap between sequence and functional understanding. A clear picture of metabolic processes across the spectrum of bacterial species is essential to enable the exploitation of microbial genomics for the purposes of environmental biotechnology. The Microme project endeavors to extend the scope of microbi ...
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 16

 TERMINÉ 

“The International Data Coordination Centre” (I-DCC)

Date du début: 1 janv. 2009, Date de fin: 30 sept. 2013,

"The I-DCC coordination and support project responds to the topic defined by HEALTH-2007-2.1.2-6 “International activities in large-scale data gathering and systems biology”. I-DCC integrates European skills, efforts, resources, and infrastructure in an international collaborative programme to establish a European Data Coordination Centre for mouse genetic resources. Large-scale mouse mutagenesis ...
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 10

 TERMINÉ 

Dissecting cGMP- and calcium-dependent signalling pathways that control gliding of a malaria zoite (Plasmodium motility)

Date du début: 1 juil. 2011, Date de fin: 30 juin 2013,

Malaria parasites critically depend on an unusual form of gliding motility to colonize their hosts and to invade cells. Transmission of malaria to the mosquito, for instance, relies on the ability of the motile zygote, the ookinete, to glide towards and invade the midgut epithelium. Results obtained in the host team have revealed a central role of cGMP- and calcium-dependent signalling in ookinete ...
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 1

 TERMINÉ 

New tools for monitoring drug resistance and treatment response in visceral leishmaniasis in the Indian subcontinent (KALADRUG-R)

Date du début: 1 nov. 2008, Date de fin: 30 avr. 2013,

"Visceral leishmaniasis (VL), one of the most-neglected infectious diseases, has an annual incidence of 500,000 cases. Early treatment is a major pillar of the current program for VL elimination on the Indian sub-continent. However, the arsenal of available drugs is very limited, and their use is jeopardized by drug resistance. Combination regimens for VL are under clinical development, but it wil ...
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 10

 TERMINÉ 

Servicing the European Biomedical Research Community: Archiving and Dissemination of Mouse Models of Human Disease (EMMAservice)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2012,

The mouse shows great similarities in development, physiology and biochemistry to humans, which makes it a key model for research into human disease. The major challenges for mouse functional genomics in the 21st century are to:1) Develop a series of mutant alleles for every gene in the mouse genome2) Determine the phenotypic consequences of each mutation3) Identify mouse models for the complete d ...
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 11

 TERMINÉ 

European Network for Genetic and Genomic Epidemiology (ENGAGE)

Date du début: 1 janv. 2008, Date de fin: 31 déc. 2012,

"ENGAGE (European Network for Genetic and Genomic Epidemiology) has, as its central objective, the translation of the wealth of data emerging from large-scale research efforts in molecular epidemiology into information of direct relevance to future advances in clinical medicine. ENGAGE will do this through the integration of very large-scale genetic and phenotypic data already available from a sub ...
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 26

 TERMINÉ 

Infrafrontier The European infrastructure for phenotyping and archiving of model mammalian genomes (INFRAFRONTIER)

Date du début: 1 mars 2008, Date de fin: 31 déc. 2012,

Medically related Life Sciences use the mouse as a model system to understand the molecular basis of health and disease in humans (>95% similarity of genes in humans and mice). An essential task for Biomedical Sciences in the 21st century will be the functional analysis of mouse models for every gene in the mammalian genome. The major bottlenecks identified by the user community will be proper ...
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 29

 TERMINÉ 

"An integrated study on three novel regulatory hubs in megakaryocytes and platelets, discovered as risk genes for myocardial infarction by a genome-wide association and platelet systems biology study" (NETSIM)

Date du début: 1 sept. 2008, Date de fin: 31 août 2012,

"The overarching objective of the ITN is to offer an intercalated study environment for young and talented researchers in the field of coronary artery disease (CAD) research. 12 PhD fellows operating in a unique training environment will work as a multi-disciplinary team to perform research spanning the full spectrum from basic to translational to bring novel inventions to the bedside. The fello ...
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 10

 TERMINÉ 

Initial Training Network: Lateralized Attention Networks (ITN-LAN)

Date du début: 1 sept. 2008, Date de fin: 31 août 2012,

"The proposed Initial Training Network for Lateralized Attention Networks (ITN-LAN) brings together 6 research teams with established international reputations and, more importantly, is founded on well established collaborations. The long-term scientific objectives of the proposed ITN-LAN are: (1) To validate and standardize a behavioural battery for assessing the attentional networks of the two ...
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 7

 TERMINÉ 

Development of low-cost technologies for the fabrication of high-performance telecommunication lasers (DeLight)

Date du début: 1 sept. 2008, Date de fin: 31 juil. 2012,

The "Development of low-cost technologies for the fabrication of high-performance telecommunication lasers" project has two main objectives:(1) Development of high-performance surface-grating-based DFB/DBR telecommunication lasers(2) Development of ultra-high speed directly modulated lasers (> 40 GBit/s) with a simplified multi-section design, which exploit high-order photonic resonances for exten ...
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 11

 TERMINÉ 

Coordination of resources for conditional expression of mutated mouse alleles (CREATE)

Date du début: 1 nov. 2008, Date de fin: 31 oct. 2011,

"This proposal describes CREATE, an internationally based Coordination Action directly addressing a large scale data gathering activity for systematic conditional mouse mutagenesis. Advances in the sophisticated manipulation of the mouse genome has established the mouse as the premier organism for developing models of human disease. Internationally coordinated initiatives have established for the ...
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 8

 TERMINÉ 

IMproving Protein Annotation and Co-ordination through Technology (IMPACT)

Date du début: 1 janv. 2008, Date de fin: 30 juin 2011,

New DNA sequencing and metagenomics projects are increasing the flow of poorly annotated raw sequence data into public databases with limited annotation. At the same time, users are imposing increasing demands on databases to include functional and contextual information, and to facilitate linking to other databases. Recent advances in technologies for achieving this and enabling complex querying ...
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 8

 TERMINÉ 

Functional and evolutionary studies of the glutamatergic synapse; a proteomic and genetic approach (PSIEMBL)

Date du début: 1 févr. 2009, Date de fin: 31 janv. 2011,

"Glutamatergic neurons are the main excitatory nerve cells in the central nervous system of mammals, in this project we aim to better understand the molecular composition of their synapses. We are particularly interested in the post synapse and the complexes of proteins associated to the NMDA glutamate receptor. We are focused in this set of molecules since the NMDA receptor is central for the est ...
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 1