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15 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

A Phase Ib/II study of MEK1/2 inhibitor PD-0325901 or MEK-162 with cMET inhibitor PF-02341066 in RASMT and RASWT (with aberrant c-MET) Colorectal Cancer Patients (MERCURIC)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2020,

Colorectal cancer (CRC) is the 3rd most common cancer in Europe, and with approximately 200,000 deaths per year, it remains the 2nd most common cause of cancer death. More than half of all CRC patients develop distant metastases and have 5-year overall survival (OS) of less than 5% because of ineffective treatments. Increased understanding of cancer biology, coupled with the implementation of “omi ...
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 13

 TERMINÉ 

Adverse Immune Signatures and their Prevention in Corneal Transplantation (VISICORT)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,

"Immune system response is the most complex barrier to long-term success of tissue transplants/implants from allogeneic and bio-artificial sources. While newly developed tissue transplant procedures are not yet performed frequently enough for robust analysis of adverse immune responses in humans, corneal transplantation (CT) is a well-established allogeneic tissue transplant with >100,000 full- an ...
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 12

 TERMINÉ 

PanCare Studies in Fertility and Ototoxicity to Improve Quality of Life after Cancer during Childhood, Adolescence and Young Adulthood (PANCARELIFE)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Survival rates after childhood cancer now reach nearly 80% in developed European countries as a result of more effective therapies and better supportive care, leading to a steady increase in the number of survivors in the population. However, the treatments that have improved survival are harsh and cause serious side-effects that can greatly impact survivors’ quality of life in the long term. The ...
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 19

 TERMINÉ 

Social innovation to improve physical activity and sedentary behaviour through elite European football clubs: European Fans in Training (EuroFIT)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Concept and aim: 20 million fans attend top division football games each week and many more watch on TV. Our social innovation is to attract people to lifestyle change through the personal connection and loyalty to the club they support. Our aim is to use this social innovation to change physical activity and sedentary behaviour, specially targeting low-SES groups, and men as well as women. EuroFI ...
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 13

 TERMINÉ 

MEsenchymal stem cells to Reduce Liver INflammation (MERLIN)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2018,

"Prevalence of liver disease is c6% (29 million people) in the EU with mortality rates from chronic liver diseases estimated at 14.3 per 100.000 in the EU-25 in 2004. Most liver diseases have a significant inflammatory component that underpins liver damage and fibrogenesis, yet current therapies have limited effectiveness. Safe novel anti-inflammatory therapies would satisfy a large unmet need for ...
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 9

 TERMINÉ 

Predictive Genomic Biomarkers Methods for Combination Bevacizumab (Avastin) Therapy in Metastatic Colorectal Cancer (ANGIOPREDICT)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2016,

In recent years the treatment paradigm for metastatic colorectal cancer (mCRC) has evolved in complexity to include newly developed targeted therapeutics. In 2004 bevacizumab (bvz) [Avastin] became the first anti-angiogenic drug to be licensed in malignant disease, based on the results of a randomised trial in advanced metastatic colorectal cancer. Nevertheless, over the past six year period emerg ...
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 12

 TERMINÉ 

Mechanisms of prevention of type 2 diabetes by lifestyle intervention in subjects with pre-diabetes or at high-risk for progression (DEXLIFE)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

"Type 2 diabetes (T2DM) is preventable by sustained changes in diet and physical exercise. Despite this, modern societies are already approaching 10% population prevalence of diabetes, and another 15% with pre-diabetes. The costs of T2DM are huge, approaching 10% of all health costs. Prevention of diabetes is a priority for national healthcare agencies and for the health insurance industry. Inve ...
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 12

 TERMINÉ 

Innovative Midlife Intervention for Dementia deterrence (In-MINDD)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2015,

The European costs of dementia were estimated €177 billion and there is a growing gap between burden and budget. The debilitation associated with dementia makes it the most feared of conditions related to ageing .Modelling studies have estimated that if obesity rates dropped by 5%, dementia prevalence rates would be lower by 6% and a decline in physical inactivity rate by 5% would reduce dementia ...
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 5

 TERMINÉ 

REsearch into implementation STrategies to support patients of different ORigins and language background in a variety of European primary care settings (RESTORE)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2015,

This project is concerned with optimising the delivery of primary healthcare to European citizens who are migrants who experience language and cultural barriers in host countries. We focus on the implementation of evidence-based health information (e.g. guidelines to enhance communication in cross-cultural consultations) and interventions (e.g. training initiatives on interculturalism and the use ...
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 8

 TERMINÉ 

Apoptosis Modelling for Treatment Decisions in Colorectal Cancer (APO-DECIDE)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2014,

"With the arrival of new colorectal cancer (CRC) therapeutics targeting specific cell signalling pathways, such as anti-EGFR therapy, personalised cancer treatment is at the door step of clinical practise. This progress in drug development contrasts strikingly with current clinical practice, where decision making depends largely on clinical factors such as tumour staging and age of patient, with t ...
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 7

 TERMINÉ 

Glycomics by High-throughput Integrated Technologies (GlycoHIT)

Date du début: 1 janv. 2011, Date de fin: 30 juin 2014,

Protein glycosylation is a post-translational phenomenon that is involved in most physiological and disease processes including cancer. Most of the known cancer-associated glycobiomarkers were discovered individually using liquid chromatography and mass spectroscopy. Though valuable, there is room for improvement in these approaches for the discovery phase. There is also a critical need for innova ...
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 16

 TERMINÉ 

Robotics UBIquitous COgnitive Network (RUBICON)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2014,

Description Self-learning robotic ecology RUBICON will create a self-learning robotic ecology, consisting of a network of sensors, effectors and mobile robot devices. Enabling robots to seamlessly operate as part of these ecologies is an important challenge for robotics R&D, in order to support ap ...
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 10

 TERMINÉ 

CULTivating Understanding and Research through Adaptivity (CULTURA)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2014,

Description CULTURA's innovative adaptive services and interactive environment will offer genuine user empowerment and unprecedented levels of engagement with digital cultural heritage collections and communitiesA key challenge facing curators and providers of digital cultural heritage is to instigate, increase and enhance engagement with ...
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 7

 TERMINÉ 

Linked Heritage - Coordination of Standards and Technologies for the enrichment of Europeana (Linked Heritage)

Date du début: 1 avr. 2011, Date de fin: 30 sept. 2013,

Linked Heritage has 3 main objectives: I) to contribute large quantities of new content to Europeana, from both the public and private sectors; II) to demonstrate enhancement of quality of content, in terms of metadata richness, re-use potential and uniqueness; III) to demonstrate enable improved search, retrieval and use of Europeana content.Linked Heritage will facilitate and deliver large-sca ...
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 38

 TERMINÉ 

Utilisation of the mesenchymal stem cell receptome for rational development of uniform, serum-free culture conditions and tools for cell characterization (PurStem)

Date du début: 1 nov. 2008, Date de fin: 30 avr. 2012,

Stem cells offer a promising avenue to therapy for a wide range of complaints. However, for this potential to be realized, a consistent and plentiful supply of well-characterised stem cells is essential. There has been relatively little progress in the development of new culture technologies for the large-scale manufacture of mesenchymal stem cells (MSCs). There is a strong possibility that this ...
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 7