36 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Regulation of DNA damage responses at the replication fork (DDRegulation)
Date du début: 1 juil. 2014, Date de fin: 30 juin 2019,
This project aims at delineating the regulatory signaling processes that enable cells to overcome DNA damage during DNA replication, a major challenge to the integrity of the genome as the normal replication machinery is unable to replicate past DNA lesions. This may result in collapse of the replication fork, potentially giving rise to gross genomic alterations. To mitigate this threat, all cells ...
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1
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TERMINÉ
Sustainable intensive pig and poultry production (PROHEALTH)
Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,
Production diseases compromise health and welfare, generating inefficiencies which impact adversely on profitability, environmental footprint, antibiotic use and product quality.The PROHEALTH project will develop understanding of the multi-factorial dimension of animal pa-thologies linked to the intensification of production and use this to develop, evaluate and disseminate ef-fective control stra ...
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24
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TERMINÉ
Advance Care Planning; an Innovative Palliative Care Intervention to Improve Quality of Life in Cancer Patients - a Multi-Centre Cluster Randomized Clinical Trial (ACTION)
Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,
"Advanced cancer typically involves multiple symptoms and seriously affects patients´ quality of life. Anxiety and depression are common. Medical care for patients with advanced cancer should be aimed at symptom control, psychosocial support, spiritual needs, and practical issues. Patients’ preferences regarding care should be central. Open and respectful communication are of key importance, but h ...
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8
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TERMINÉ
Microbiome Influence on Energy balance and Brain Development-Function Put into Action to Tackle Diet-related Diseases and Behavior (MyNewGut)
Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,
Emerging evidence indicates that the gut microbiome contributes to our ability to extract energy from the diet and influences development and function of the immune, endocrine and nervous systems, which regulate energy balance and behaviour. This has led to hypothesize that developing microbiome-based dietary interventions can be cost-effective measures to prevent diet-related and behavioural diso ...
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30
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TERMINÉ
Application of advanced technologies and stochastic modeling in the study of submarine groundwater discharge (SUBGRODIS)
Date du début: 1 juil. 2015, Date de fin: 30 juin 2018,
"Submarine Groundwater Discharge (SGD) is the subsurface flow of continental water to the sea or coastal water systems. It has become increasingly important during recent years due to the effect on coastal ecosystems associated with the contaminants produced either naturally or anthropogenically inland. The increasing impact of this problem is illustrated by the inclusion of protection figures in ...
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1
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TERMINÉ
Biopolymer Based FOOd Delivery Systems (BIBAFOODS)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2018,
"The “BIopolymer BAsed FOOd Delivery Systems” (BIBAFOODS) network will train young researchers for the advancement of food science and technology, by providing them with the complementary skills necessary to develop the future sustainable food industry and entrepreneurial skills crucial for creating biotechnological food oriented start-up companies. This collaborative training network will combine ...
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11
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TERMINÉ
Upscaling human insulin-producing beta cell production by efficient differentiation and expansion of endoderm progenitors (HumEn)
Date du début: 1 janv. 2014, Date de fin: 31 déc. 2017,
Despite progress in producing beta cells from human pluripotent stem cells (hPSCs) in recent years, full differentiation cannot be obtained in vitro. The HumEn project hypothesises that a fundamental understanding of the coupling between endodermal progenitor expansion and differentiation is relevant for elucidating how to a) generate glucose-responsive beta cells from hPSCs in vitro, and b) gener ...
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9
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TERMINÉ
Food-based solutions for Optimal vitamin D Nutrition and health through the life cycle (ODIN)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,
Vitamin D deficiency has significant implications for human health and impacts on healthy growth and development and successful aging. Fundamental knowledge gaps are barriers to implementing a safe and effective public health strategy to prevent vitamin D deficiency and optimize status. ODIN will provide the evidence to prevent vitamin D deficiency in Europe and improve nutrition and public health ...
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32
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TERMINÉ
Enhancing prediction of tropical Atlantic climate and its impacts (PREFACE)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,
Tropical Atlantic climate recently experienced pronounced shifts of great socio-economic importance. The oceanic changes were largest in the eastern boundary upwelling systems. African countries bordering the Atlantic strongly depend upon their ocean - societal development, fisheries, and tourism. They were strongly affected by these climatic changes and will face important adaptation challenges a ...
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30
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TERMINÉ
Green Infrastructure and Urban Biodiversity for Sustainable Urban Development and the Green Economy (GREEN SURGE)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,
"GREEN SURGE will identify, develop and test ways of connecting green spaces, biodiversity, people and the green economy, in order to meet the major urban challenges related to land use conflicts, climate change adaptation, demographic changes, and human health and wellbeing. It will provide a sound evidence base for green infrastructure planning and implementation, exploring the innovation potent ...
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28
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TERMINÉ
An integrated strategy for the conservation and use of underutilized Latin American agrobiodiversity (LATINCROP)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,
"LATINCROP objectives are to reinforce agrobiodiversity conservation in the Andean region; to identify promising underutilized species for commercial initiatives and improved food security; and to integrate activities into a strong network between relevant stakeholders in Latin America and the EU. The project will identify attractive species for marginal lands involving novel crop combinations thu ...
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9
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TERMINÉ
Analytical Research In ADME profiling (ARIADME) (ARIADME)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,
The integration of absorption, distribution, metabolism and excretion (ADME) profiling into early drug discovery has been put forward as a strategy for reducing drug candidate attrition. Europe is challenged to develop novel ADME screening methodologies with increased efficiency and predictive power to profile the multitude of lead compounds currently being generated. The principal objective of th ...
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6
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TERMINÉ
Individualised Diagnostics and Rehabilitation of Attention (INDIREA)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,
"We propose a training network based around a linked set of research projects which attempt to improve the diagnosis and rehabilitation of neuropsychological disorders of attention, with each project linked to an external industrial partner in order to commercialise emerging diagnostic and rehabilitation procedures. New diagnostic procedures will link clinical measures of attentional disorders to ...
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8
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TERMINÉ
The European non-coding RNA network (RNATRAIN)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,
"Non-coding RNA (ncRNA) is a new research field in rapid development. It holds the potential to explain many fundamental biological phenomena and there is a vast prospective for the development of ncRNA-derived diagnostic and therapeutic tools. Hence, biotech and pharmaceutical companies are actively looking into this unexplored territory for novel targets. Therefore, there is a substantial and un ...
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11
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TERMINÉ
Quantum Mechanical Nature of Black Holes (QUNAT)
Date du début: 1 août 2013, Date de fin: 31 juil. 2017,
"The overall objective of this proposal is to understand the quantum mechanical nature of black holes. The proposal aims to do this by finding a quantum mechanical description of black holes by employing the Holographic Principle as manifested in the AdS/ CFT correspondence between Gauge Theory and String Theory. This is a highly challenging and deep conceptual problem to understand. The researche ...
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1
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TERMINÉ
The role of boron in the crystallization and surface properties of CaCO3 at the nanoscale (NANOCARB)
Date du début: 1 janv. 2015, Date de fin: 11 avr. 2017,
Boron is important in industry and nature. It is used in oil extraction, detergents, superconductors and agricultural chemicals. At neutral to slightly basic pH, where CaCO3 forms, B exists as boric acid and borate. These are present in all sea water so marine organisms automatically incorporate B into their shells. Strangely, nearly nothing is known about the extent of uptake or its effects. In m ...
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1
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TERMINÉ
Intrinsic Complexity of Rule-Based Systems (RUBYX)
Date du début: 1 déc. 2014, Date de fin: 9 mars 2017,
"The RUBYX project will extend the theoretical foundations for the area of rule-based systems used in theoretical computer science to model biological and chemical processes with the aim of extending their areas of application to new areas. Rule-based systems give rise to systems of differential equations that describe the evolution of the biochemical systems modelled, but which are too complex to ...
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1
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TERMINÉ
Mechanistic modeling of the formation of bioactive compounds in high pressure processed seedlings of Brussels sprouts for effective solution to preserve healthy compounds in vegetables (HPBIOACTIVE)
Date du début: 16 févr. 2015, Date de fin: 15 févr. 2017,
Health and quality of life of the European citizens is threatened by degenerative diseases with increased social and health care expenses. The health gains of food consumed are an important key to tackle this challenge; by developing new healthier food products or ingredients to be included in daily meals. In both cases, consumer acceptance is important and healthy bioactive compounds (BC) natural ...
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1
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TERMINÉ
Functional non-coding mutations in human cancer (CancerGenomes)
Date du début: 1 févr. 2015, Date de fin: 31 janv. 2017,
There is an urgent need to improve approaches for cancer diagnosis and targeted treatment, which requires a detailed understanding of the disease and its genetic basis. The advent of next-generation sequencing has allowed researchers to obtain comprehensive profiles of acquired genetic mutations in patient tumors. However, due to primarily reasons of cost, these sequencing approaches have so far i ...
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1
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TERMINÉ
An ethical, legal and practical perspective on the impact of a new regulatory framework for the scientific use of animals on research and innovation (ANIMPACT)
Date du début: 1 oct. 2013, Date de fin: 31 déc. 2016,
Research with animals is considered necessary to obtain certain vital knowledge for advancing health research and innovation, but the harm such research may cause animals is ethically problematic. The European legislation regulating animal experimentation is based on the need to balance the two important interests at stake: advancing research and protecting animal welfare. The public sensitivity o ...
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6
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TERMINÉ
Interfacing Quantum Optical, Electrical, and Mechanical Systems (iQUOEMS)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2016,
This project aims at the efficient realization of quantum interfaces for high-fidelity conversion and coherent manipulation of quantum states of phonons and of photons at vastly distinct wavelengths. We will consider different experimental platforms, e.g. photonic crystal cavities, nonlinear crystalline resonators, graphene-based nanoelectromechanical systems, and nanomembranes, with the aim of im ...
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6
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TERMINÉ
"Specification of anterior definitive endoderm, the role of extracellular matrix and Akt1 signalling" (SPECADE)
Date du début: 1 janv. 2014, Date de fin: 6 sept. 2016,
"Deciphering the specific role of signalling and the niche in which cells develop and differentiate is one of the central problems of developmental biology. Approaching this problem has been difficult in vivo, as embryonic development involves complex signalling machinery directly instructing the cell fate, or influencing the environment which itself drives the cell specification. Embryonic stem ( ...
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1
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TERMINÉ
Topology and dynamics in driven quantum systems (TOPDRIVE)
Date du début: 1 sept. 2014, Date de fin: 31 août 2016,
Advances in experimental capabilities over the past decade have given researchers unprecedented access to the quantum mechanical properties of matter in systems of ever-growing size, opening many possibilities for exploring deep fundamental questions about the nature of quantum mechanics in complex/macroscopic systems, and for potential transformative practical advances, e.g. by enabling quantum i ...
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1
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TERMINÉ
Feedback Regulated Star Formation in Diverse Galactic Environments (FEEDGAL)
Date du début: 1 mars 2014, Date de fin: 6 juin 2016,
Three major unresolved issues in modern Astrophysics are the origin of the initial mass function of stars and it potential universality, the nature and interplay of physical processes that regulate the star formation rates and efficiencies in star forming molecular clouds, and the origin of turbulent motions in the clouds and in the interstellar medium. Over the last two decades, the effects of ph ...
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1
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TERMINÉ
Nanocatalytic drugs towards Alzheimer's disease (ORGANOZYMES)
Date du début: 1 juin 2014, Date de fin: 31 mai 2016,
Here is proposed nano-scale synthesis and combinatorial screening of medium sized peptide-transition metal catalyst libraries with the aim of producing libraries for screening highly selective catalysts for development of nano-medicines. The implementation of catalytic molecules as medicines is a new paradigm in treatment that can overcome a number of the difficulties with present drugs. As with r ...
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1
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TERMINÉ
The impact of collisional dark matter in galaxy formation: Time for a paradigm shift? (GALFORM_SELFIDM)
Date du début: 1 mars 2014, Date de fin: 25 mai 2016,
"Discovering the nature of dark matter is one of the most significant challenges for modern astrophysics. The favourite theoretical model, the Cold Dark Matter (CDM) paradigm, assumes that dark matter is made of collisionless particles acting on galactic scales purely through gravitational interactions.Despite that the CDM model is remarkably successful in reproducing the large-scale structure of ...
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1
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TERMINÉ
Development of an objective method to perform quality classification of comminuted poultry meat (MACSYS)
Date du début: 1 janv. 2014, Date de fin: 31 mars 2016,
Deboning of meat is an important technology to improve yield and sustainability of meat production. But mechanically separated meat (MSM) is generally considered to be of inferior quality, and its use is subject to strict regulations. In contrast, manually separated meat is accepted as regular meat, and not subject to the same restrictions. But development of the technology for mechanical processe ...
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10
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TERMINÉ
The Actinomycete Connection (TACTIC)
Date du début: 1 avr. 2014, Date de fin: 31 mars 2016,
Mutualisms underpin much of the complexity of the natural world, in interactions as diverse as coral bleaching, nitrogen fixation in root nodules, and the human gut microbiomes. Understanding how interspecific mutualisms (cooperation between different species) can be stable over many generations is a key unresolved subject within evolutionary biology.Fungus-farming attine ants are an excellent mod ...
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1
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TERMINÉ
Identifying Functional Proteins at DNA Breaks with Quantitative Proteomics in Primary Lymphocytes (DDR IN LYMPHOCYTES)
Date du début: 1 avr. 2014, Date de fin: 31 mars 2016,
DNA double-strand breaks (DSBs) in our genome that are not repaired properly can lead to various developmental, immunological, and neurological disorders and are a major driver for genomic instability and tumorigenesis. The role of chromatin accessibility is of key importance to understand how the DNA/chromatin template senses and amplifies the DNA damage signal to properly repair the DNA in its n ...
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1
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TERMINÉ
Rac1 function in Intestinal stem cells (Rac1ISC)
Date du début: 1 avr. 2014, Date de fin: 31 mars 2016,
Diseases that affect the digestive system are the most common causes of mortality.The intestinal epithelium is a highly proliferative tissue, where most cells are replaced on a weekly basis. Intestinal stem cells (ISCs) are crucial for tissue maintenance and regeneration after wounding. Homeostasis within the stem cell compartment is controlled by extrinsic and intrinsic signals. The intrinsic cel ...
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1
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TERMINÉ
Supermassive black holes under the microscope: Revealing the dusty environment of AGN on parsec scales with IR and sub-mm interferometry (PARSECDUST)
Date du début: 1 mars 2014, Date de fin: 29 févr. 2016,
The evolution of galaxies and their central supermassive black holes are intimately related. As such, it is of great interest to understand the active growth phase of these black holes and their influence on the surrounding host galaxies. I propose a project to study the outer, dusty region of mass accretion onto supermassive black holes with the objective to address the following open questions:* ...
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2
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TERMINÉ
The incretin system: From genetic determinants to impact on early development of type 2 diabetes in the population (INSGEN)
Date du début: 1 mars 2014, Date de fin: 29 févr. 2016,
The incretin hormones (GLP-1 and GIP) are secreted from the gut in response to food intake and their primary role is to amplify nutrient-induced insulin release. Most of this effect is lost in obesity and type 2 diabetes. Glucagon acts as a counter-regulatory hormone to insulin and may therefore also be essential in type 2 diabetes pathophysiology. My objective is to carry out a unique combination ...
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1
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TERMINÉ
Thermostable transaminases for the synthesis of pharmaceutical building blocks (HOTRAM)
Date du début: 1 mars 2014, Date de fin: 29 févr. 2016,
Biocatalysis is considered a key component for the development of a sustainable chemistry in Europe by the European Commission, CEFIC and Biotech Industries Association. Indeed, the use of enzymes as biocatalysts in the chemical and pharmaceutical industries has been constantly growing in the last years.Aim of this project is to screen and obtain novel thermostable omega-Transaminases (TAs) from t ...
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1
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TERMINÉ
Hybrid Nanowire Devices for Quantum Information Processing (HYWIRE)
Date du début: 1 mars 2014, Date de fin: 29 févr. 2016,
Semiconducting nanowires are a promising materials system for quantum information processing applications. Presently, there is much interest in using nanowires to support both spin qubits and, when contacted by a superconductor, Majorana fermions. The overall aim of the proposed research will be to develop the next generation of hybrid superconductor semiconductor nanowire quantum devices using ul ...
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1
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TERMINÉ
Identification of novel regulators of translesion DNA synthesis in human cells (BIOID IN TLS)
Date du début: 1 janv. 2014, Date de fin: 31 déc. 2015,
Here, I propose to unravel the molecular mechanisms that regulate TLS during DNA damage bypass through advanced complementary approaches.Thousands of DNA damaging insults are inflicted daily upon the genomes of all living cells. If left unrepaired, these lesions can be life-threatening for organisms as they alter the content and organization of the genetic material. To overcome this constant chall ...
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1
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TERMINÉ
Nanosystems for the early Diagnosis of Neurodegenerative diseases (NADINE)
Date du début: 1 sept. 2010, Date de fin: 31 août 2015,
Medical diagnosis is currently undergoing a major revolution due to the fast discovery of molecular biomarkers, and the development of multimodal “metabiomarker” signatures. Progress, however, is hindered by low abundance of many biomarkers of interest in body fluids, in absolute concentration and with regard to other biomolecules. The aim of the present project is to apply these progresses in bio ...
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