12 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
3D structures of bacterial supramolecular assemblies by solid-state NMR (assemblyNMR)
Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,
Supramolecular assemblies – formed by the self-assembly of hundreds of protein subunits – are part of bacterial nanomachines involved in key cellular processes. Important examples in pathogenic bacteria are pili and type 3 secretion systems (T3SS) that mediate adhesion to host cells and injection of virulence proteins. Structure determination at atomic resolution of such assemblies by standard tec ...
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2
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TERMINÉ
Ion homeostasis and volume regulation of cells and organelles (CYTOVOLION)
Date du début: 1 avr. 2012, Date de fin: 31 mars 2017,
...olume changes of cells, and possibly also of intracellular organelles, in turn regulate ion transport across their membranes. Whereas several swelling-activated plasma membrane ion transporters and channels are known, the molecular identity of a key player, the swelling-activated anion channel VRAC, and its impact on cellular functions remain elusive. Only sketchy information is available on ion h ...
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1
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TERMINÉ
Enabling Technologies for High Power Terahertz Electronic Circuitry (THZPOWERELECTRONICS)
Date du début: 1 avr. 2013, Date de fin: 31 mars 2017,
The Terahertz range (300 GHz – 3 THz) of the electromagnetic spectrum is largely unused for the lack of solid-state Terahertz electronic components. Exciting applications can be found in many areas including Communications, Navigation, Security, Material Engineering, and Medical and Life Sciences, owing to the character of Terahertz electromagnetic radiation. Examples of applications are high-band ...
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1
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TERMINÉ
Innovative anti-influenza drugs excluding viral escape (ANTIFLU)
Date du début: 1 juin 2011, Date de fin: 31 mai 2016,
ANTIFLU is to develop innovative drugs against influenza virus infections based on a novelconcept that precludes the development of viral resistance and ensures efficacy againstupcoming pandemic influenza strains. Viral replication is known to depend on multiple hostfactors. Whilst traditional anti-influenza treatments usually target viral factors, ANTIFLU willaim at drugs interfering with host-re ...
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11
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TERMINÉ
Building data bridges between biological and medical infrastructures in Europe (BIOMEDBRIDGES)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,
The ESFRI infrastructures in Biological and BioMedical Sciences face substantial challenges in accessing and sharing data and resources. The BioMedBridges consortium brings together the six established ESFRI infrastructures with common goals to define, implement and deliver data interoperability across the biological and biomedical domains.The first objective is to ensure that interoperable stand ...
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26
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TERMINÉ
European Infrastructure of Open Screening Platforms for Chemical Biology (EU-OPENSCREEN)
Date du début: 1 nov. 2010, Date de fin: 30 avr. 2015,
The EU-OPENSCREEN Preparatory Phase forms the basis for the construction and operation of a pan-European infrastructure of open screening platforms for Chemical Biology. EU-OPENSCREEN will bring together leading laboratories from 14 European countries covering all aspects of Chemical Biology from high-throughput screening with a dedicated compound library to assay development, chemical synthesis f ...
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24
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TERMINÉ
Hyperpolarized Biosensors in Molecular Imaging (BiosensorImaging)
Date du début: 1 déc. 2009, Date de fin: 30 nov. 2014,
Xenon biosensors have an outstanding potential to increase the significance of magnetic resonance imaging (MRI) in molecular imaging and to combine the advantages of MRI with the high sensitivity of hyperpolarized Xe-129 and the specificity of a functionalized contrast agent. Based on new detection schemes (Hyper-CEST method) in Xe MRI, this novel concept in molecular diagnostics will be made avai ...
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1
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TERMINÉ
NMR for Structural Biology (Bio-NMR)
Date du début: 1 sept. 2010, Date de fin: 31 août 2014,
In the past two decades spectacular insight into basic principles of life has been obtained from paradigmatic high-resolution structural investigations providing a rational basis for biological experiments. NMR is an indispensable enabling technology for determining such structures and their interactions in solution, the immobilized state and living cells. The power of NMR to link structural, dyna ...
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20
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TERMINÉ
Blood-brain barrier junctions as targets for paracellular drug delivery to the brain (JUSTBRAIN)
Date du début: 1 nov. 2009, Date de fin: 30 avr. 2014,
"To maintain homeostasis of the central nervous system (CNS) the blood-brain barrier (BBB) prevents the free transcellular passage of hydrophilic molecules from the blood into the CNS. Because of this, the BBB is now recognised as the major obstacle to the treatment of most neurological disorders, as it hinders the delivery of many potentially important therapeutic and diagnostic substances to the ...
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8
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TERMINÉ
"Exploiting the Potential of Structural Biology through NMR and Associated Technologies - Opportunities for Economic Development of Pharma/Biotech in Tuscany, Berlin-Brandenburg and Beyond" (EPISODE)
Date du début: 1 janv. 2009, Date de fin: 31 déc. 2011,
"EPISODE’s goal is to maximize the regional benefits of Structural Biology Research Infrastructures in NMR and associated technologies for the economic development of the pharma/biotech industries in Tuscany, Berlin-Brandenburg and beyond. As traditional Structural Biology research moves towards new horizons, a major goal has become a systemic view of Life, implying a change of focus from single ...
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12
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TERMINÉ
Structure and dynamics of desensitization in glutamate receptors (S-DODGR)
Date du début: 1 avr. 2011, Date de fin: 30 juin 2011,
"AMPA and kainate receptors mediate fast excitatory synaptic transmission. AMPA receptor ligand-binding domains form dimers, which are well-known to control ion channel activation and desensitization. The dimer stability is related to the rate and extent of desensitization. Despite the similarity in structure between AMPA and kainate receptors, they present a clear difference in function, suggesti ...
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1
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TERMINÉ
SEVERE ACUTE RESPIRATORY SYNDROME (SARS): DESIGN, SYNTHESIS, IDENTIFICATION, AND EVALUATION OF NOVEL NON-PEPTIDIC INHIBITORS OF MAIN PROTEASE EMPLOYING DYNAMIC LIGATION SCREENING (DLS) (PISARSCoV)
Date du début: 1 mars 2009, Date de fin: 28 févr. 2011,
The Severe Acute Respiratory Syndrome (SARS) emerged in 2003 in Asia, and within a few months infected 8500 people world and caused more than 800 deaths. This novel medical condition is a viral respiratory illness caused by the SARS-associated coronavirus (SARS-CoV). And at present, no efficacious therapy is available, for these reason finding a useful drug candidate against SARS corona virus is a ...
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