12 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Tribbles Research and Innovation Network (TRAIN)
Date du début: 1 sept. 2016, Date de fin: 31 août 2020,
This proposal was developed in the context of the medical need to tackle the clinical consequences of obesity-related diseases more holistically. Dysregulation of common molecular pathways that govern the physiological functioning of adipocytes, immune cells and prostate epithelium cells have been reported in immuno-metabolic disease (such as obesity) and several cancers. The individual projects ...
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10
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TERMINÉ
A training network for the rational design of the next generation of well-defined glycoconjugate vaccines (GLYCOVAX)
Date du début: 1 nov. 2015, Date de fin: 31 oct. 2019,
GLYCOVAX is a network for the education of promising young scientists who will learn how to rationally design a next generation of well-defined and innovative glycoconjugate vaccines to improve current preventive therapies and to tackle unmet medical needs. Glycoconjugate vaccines represent the key for success of vaccination in children. The covalent linkage to proteins renders carbohydrates able ...
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12
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TERMINÉ
First Chemoselective Synthesis and Structural Studies of Lasso Peptides (FCSSSLP)
Date du début: 5 juil. 2016, Date de fin: 4 juil. 2019,
The main objective of this project is to promote the use of peptides as potential therapeutic agents. We now know that ribosomal peptides, and specifically lasso peptides, which are biosynthesized by bacteria as agents of defense, show a compact and rigid structure, giving a high stability against physical, chemical and proteolytic degradation. The spectrum of biological activities of these peptid ...
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1
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TERMINÉ
Toll-Like Receptor 4 activation and function in diseases: an integrated chemical-biology approach. (TOLLerant)
Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,
Based on an international team derived from the COST action BM1003 (www.cost-bm1003.info, 2011-2014) and thus relying on consolidated group interactions and synergies and on a unique combination of chemistry, biology, biophysics, biochemistry and pharmacology expertise, the TOLLerant project aims to gain information on molecular aspects of TLR4 activation and signaling by using synthetic and natur ...
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10
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TERMINÉ
Anti-tick Vaccines to Prevent Tick-borne Diseases in Europe (ANTIDotE)
Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,
Background Ixodes ricinus transmits bacterial, protozoal and viral pathogens that cause Lyme borreliosis, babesiosis and tick-borne encephalitis respectively and exceedingly affect Central and Eastern Europe (CEE). During feeding, ticks introduce salivary proteins in the skin that interfere with host defense mechanisms. However, in animals repeated tick infestations as well as vaccination against ...
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8
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TERMINÉ
Metabolic requirements for prostate cancer cell fitness (CancerMetab)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,
The actual view of cellular transformation and cancer progression supports the notion that cancer cells must undergo metabolic reprogramming in order to survive in a hostile environment. This field has experienced a renaissance in recent years, with the discovery of cancer genes regulating metabolic homeostasis, in turn being accepted as an emergent hallmark of cancer. Prostate cancer presents one ...
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1
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TERMINÉ
Unravelling the Nascent Code: Signals sensed and transmitted by the nascent chain to acquire its functional state or reprogram gene expression (THE NASCENT CODE)
Date du début: 14 juil. 2014, Date de fin: 13 juil. 2018,
"Emerging biochemical and biophysical data strongly suggest that the transformation of the potential set of proteins, encrypted in the genome, into its actual vital functional set, is a manifestation not just of the genetic code, but of an additional layer of information encoded within the newly synthesized polypeptide nascent chain. To date, we know that immediately upon the first steps of protei ...
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1
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TERMINÉ
Novel vaccine and diagnostic strategies against Schmallenberg virus (SchmaVirusVacDiag)
Date du début: 15 juin 2015, Date de fin: 14 juin 2017,
Schmallenberg virus (SV) is a pathogen that has been discovered in European livestock 3 years ago. Since then, it has been found that this virus is associated with disease in sheep, goats and cattle across Europe . In livestock, the symptoms associated with the disease include stillbirths and malformations in newborn animals. The presence of the virus in Spain, France, Germany, Italy, the UK, t ...
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1
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TERMINÉ
Cholesterol metabolism as a driver of prostate cancer aggressiveness (ACM)
Date du début: 1 avr. 2015, Date de fin: 31 mars 2017,
According to the WHO, prostate cancer (PCa) is the most common cancer in men in the European Union (EU). The current view of cellular transformation and cancer progression supports the notion that cancer cells must undergo a metabolic reprogramming in order to survive in a hostile environment. Tumors are not homogeneous entities, and most cancers retain a differential fraction of cells with increa ...
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1
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TERMINÉ
Implication of energy sensing pathways in prostate cancer biology (PTENLKB1)
Date du début: 2 janv. 2012, Date de fin: 1 janv. 2016,
"Prostate cancer is among the most prevalent forms of cancer in men and the fifth cause of dead from cancer in men worldwide. Therefore, the understanding of prostate cancer biology is a key step in the development of new effective therapeutic approaches. In this line, the use of genetically engineered mouse models has been critical in the understanding of the genetic cues that regulate the proces ...
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1
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TERMINÉ
European Research Training in the Ubiquitin Proteasome System (UPStream)
Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,
The main objective of the international training network UPStream is the training of a novel generation of European scientist in a critical and complex field of modern biology: the understanding of the regulation of the UPS and its potential use for drug development. The importance of this process is illustrated by the imperious necessity to destroy certain proteins during several phases of the ce ...
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10
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TERMINÉ
Integration of Novel Nanoparticle based Technology for Therapeutics and Diagnosis of different types of Cancer (NANOTHER)
Date du début: 1 sept. 2008, Date de fin: 31 août 2012,
The breakthrough objective of NANOTHER is to develop & characterise a novel nanoparticle system that will be used as a therapeutic agent or diagnosis tool for breast cancer, colorectal cancer & bone metastasis. Theranostics, the development of nanoparticles with both functionalities, will also be carried out using the hyperthermic effect to kill tumour cells or to release the selected drug . The n ...
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