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 TERMINÉ 
The preparation of complex molecular architectures employing multi-component reactions where the number of bond-forming events is maximised is a central goal of the discipline of Organic Synthesis. The contemporary, pressing need for sustainable chemical reactions has raised the demand for novel reaction families that explore the concept of redox-neutrality and proceed with the generation of minim...
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 TERMINÉ 
The vision of EU-ToxRisk is to drive a paradigm shift in toxicology towards an animal-free, mechanism-based integrated approach to chemical safety assessment. The project will unite all relevant disciplines and stakeholders to establish: i) pragmatic, solid read-across procedures incorporating mechanistic and toxicokinetic knowledge; and ii) ab initio hazard and risk assessment strategies of chemi...
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 43

 TERMINÉ 

Evolution and Impact of Heterochromatin on a Young Drosophila Y chromosome (UNICODE)

Date du début: 1 août 2016, Date de fin: 31 juil. 2021,

The transition from euchromatin to heterochromatin is a fundamental process that particularly reshaped the epigenomic landscape of Y chromosome. Its definitive genomic underpinning and broad functional impact are still unclear, as heterochromatin (e.g., that of human Y) is usually too repetitive to study. I have previously demonstrated that, the young Y (‘neo-Y’) chromosome of Drosophila miranda h...
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 TERMINÉ 
The emergence of complex eukaryotic life forms on Earth from prokaryotic cells is one of the most fundamental questions in biology and also one of the least understood transitions in evolution. Phylogenomic studies recently indicated that the eukaryotic line of descent arose from within the TACK+L superphylum of Archaea. This proposal addresses the systematic analysis of two newly discovered, but ...
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 1

 TERMINÉ 
"China’s success story of the past three decades is seen as an anomaly. Market-based reforms have generated an economic system that can hardly be described as socialist anymore, but the Communist Party of China remains in power. Although social unrest is on the rise, the CCP enjoys the consent of the overwhelming majority of its people. Most agree that China’s economic performance is the key to so...
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 TERMINÉ 
The project seeks to explore culinary practice among early farming European communities, from the Aegean to Central Europe, spanning the Neolithic through to the Iron Age (7th-1st millennia BC). The project seeks to identify the ‘food cultures’ of prehistoric Europe, and to reconstruct how cultivated and wild plant foods were transformed into dishes exploring their underlying cultural and environm...
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 5

 TERMINÉ 
I propose to study how eukaryotic cells generate autophagosomes, organelles bounded by a double membrane. These are formed during autophagy and mediate the degradation of cytoplasmic substances within the lysosomal compartment. Autophagy thereby protects the organism from pathological conditions such as neurodegeneration, cancer and infections. Many core factors required for autophagosome formatio...
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 TERMINÉ 
The physical laws of diffraction generally limit the spatial resolution of optical systems, being about 200 nm for light in the visible range. Within ChipScope we want to overcome this limit by developing the scientific and technological basis for a completely new approach to optical superresolution, based on semiconductor nano Light Emitting Diode (nanoLED) arrays with individual pixel operation....
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 7

 TERMINÉ 
The INFRAFRONTIER RI integrates European Mouse Clinics and the European Mouse Mutant Archive with the common goal to ensure access to mouse models for basic research of human health and disease, and to translate this knowledge into therapeutic approaches for the benefit of the European society. The expanded INFRAFRONTIER2020 network, coordinated by the INFRAFRONTIER GmbH, includes 3 SMEs and is st...
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 33

 TERMINÉ 
The EN-ACTI2NG program (European Network on Anti-Cancer Immuno-Therapy Improvement by modification of CAR and TCR Interactions and Nanoscale Geometry) emanates from the recent clinical evidence that T cells expressing engineered tumor-specific immune receptors can eradicate certain tumors that do not respond to conventional treatment. To obtain T cells with reactivity to a wider array of tumors an...
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 11

 TERMINÉ 
A novel concept for a photo-electro-catalytic (PEC) cell able to directly convert water and CO2 into fuels and chemicals (CO2 reduction) and oxygen (water oxidation) using exclusively solar energy will be designed, built, validated, and optimized. The cell will be constructed from cheap multifunction photo-electrodes able to transform sun irradiation into an electrochemical potential difference (e...
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 15

 TERMINÉ 
Advanced Microscopy techniques are widely recognized as one of the pillars onto which the research and manufacture of Nanotechnology based products is sustained. At present, the greatest challenge faced by these techniques is the realization of fast and non-destructive tomographic images with chemical composition sensitivity and with sub-10 nm spatial resolution, in both organic and inorganic mate...
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 10

 TERMINÉ 
Companion diagnostics are crucial for drug development and disease management with regard to patient selection, therapy planning and monitoring. Nanomedicines such as antibodies have been proven to be optimal disease-targeting agents because they generally exhibit superior target uptake and retention. However, to date, nuclear imaging of nanomedicines has been limited to the use of long-lived isot...
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 6

 TERMINÉ 
An increasing number of nanomaterials (NMs) are entering the market in every day products spanning from health care and leisure to electronics, cosmetics and foodstuff. Nanotechnology is a truly enabling technology, with unlimited potential for innovation. However, the novelty in properties and forms of NMs makes the development of a well-founded and robust legislative framework to ensure safe dev...
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 27

 TERMINÉ 

OMT - Optomechanical Technologies (OMT)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2020,

The proposed project is built on the successful training and research experience of the leading European research groups working in the field of cavity optomechanics. Our ENT unites a total of 14 leading groups in the field, of which two are major industrial players that utilize MEMS and NEMS - Bosch and IBM. The main goal of the project is to exploit optomechanical interactions in views of novel...
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 14

 TERMINÉ 
E-CAM will create, develop and sustain a European infrastructure for computational science applied to simulation and modelling of materials and of biological processes of industrial and societal importance. Building on the already significant network of 15 CECAM centres across Europe and the PRACE initiative, it will create a distributed, sustainable centre for simulation and modelling at and acro...
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 18

 TERMINÉ 
Soils are considered the last scientific frontiers that harbor one of the most diverse microbial communities on Earth. It is hypothesized that this diversity allows for redundancy in microbial key processes, thereby ensuring ecosystem stability. Much of this functional redundancy is embodied in non-active, dormant microorganisms that represent the ‘microbial seed bank’, which is characterized by a...
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 1

 TERMINÉ 
This project aims at a better understanding of the philosophical richness of ninth century thought using the unprecedented and highly innovative method of the synchronic approach. The hypothesis directing this synchronic approach is that studying together in parallel the four main philosophical traditions of the century – i.e. Latin, Greek, Syriac and Arabic – will bring results that the tradition...
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 1

 TERMINÉ 

The artificial pancreas in children aged 1 to 7 years with type 1 diabetes (KidsAP)

Date du début: 1 janv. 2017, Date de fin: 30 juin 2020,

TYPE 1 DIABETES is one of the most COMMON CHRONIC diseases in children with a RAPID increase in number of cases particularly in young children. Type 1 diabetes is associated with LIFE-LONG dependency on insulin administration. POOR glucose control leads to diabetes COMPLICATIONS, e.g. eye, heart, kidney disease, including BRAIN changes in young children. Episodes of VERY LOW glucose levels may be ...
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 14

 TERMINÉ 
Background The worldwide demand for nickel (Ni) is experiencing an unprecedented growth under current industrial and economic pressures. The European Innovation Partnership (EIP) classified Ni as a raw material with high economic importance. However, mine production mainly takes place outside of the European Union, whose mine output (in New Caledonia, Gre...
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 9

 TERMINÉ 
The project will examine the histories of yoga, ayurveda and rasashastra (Indian alchemy and iatrochemistry) from the tenth century to the present, focussing on the disciplines' health, rejuvenation and longevity practices. The goals of the project are to reveal the entanglements of these historical traditions, and to trace the trajectories of their evolution as components of today's global health...
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 2

 TERMINÉ 
Quantum physics and general relativity are probably the most successful and well-tested theories of modern science. At the same time, their fundamental concepts are so dramatically different that there is disagreement on the most obvious questions such as “how does a mass in a quantum superposition state gravitate?“. Achieving progress on such foundational questions requires experiments at the int...
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 1

 TERMINÉ 

Connecting Science with Society (EU-PolarNet)

Date du début: 1 mars 2015, Date de fin: 29 févr. 2020,

The rapid changes occurring in the Polar Regions are significantly influencing global climate with consequences for global society. European polar research has contributed critical knowledge to identifying the processes behind these rapid changes but, in contrast to lower latitudes, datasets from the Polar Regions are still insufficient to fully understand and more effectively predict the effects ...
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 22

 TERMINÉ 
FlowerPower aims at establishing a new generation of horticulturists capable of exploiting plant genetic resources in an innovation oriented way using cutting edge technology. The co-operation between the professional horticultural industry, a research-oriented company in the field of functional genomics and scientists from five Universities from 3 countries addresses urgent needs in the non-acade...
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 4

 TERMINÉ 

TRANSPORT OF SOFT MATTER AT THE NANOSCALE (NANOTRANS)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

We propose a Multi-Partner ITN-ETN network on Transport of Soft Matter at the Nanoscale. The scientific topic, which is the focus of the proposal, is an emerging field of science and technology. Challenges such as design of environmentally friendly engineering materials or understanding the principles of biological organization crucially depend on fundamental understanding of transport of fluids a...
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 10

 TERMINÉ 

Innovative Management of Genetic Resources (IMAGE)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

This aim of IMAGE is to enhance the use of genetic collections and to upgrade animal gene bank management. IMAGE will better exploit DNA information and develop methodologies, biotechnologies, and bioinformatics for rationalising animal genetic resources. It will demonstrate the benefits brought by gene banks to the development of sustainable livestock systems by: enhancing the usefulness of genet...
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 28

 TERMINÉ 
INTCATCH will instigate a paradigm shift in the monitoring and management of surface water quality that is fit for global waters in the period 2020-2050. INTCATCH will do this by developing efficient, user-friendly water monitoring strategies and systems based on innovative technologies that will provide real time data for important parameters, moving towards SMART Rivers. The business model will...
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 23

 TERMINÉ 
Background The northern bald ibis is listed as ‘critically endangered’, with only one remaining colony in Morocco (consisting of around 200 adults) and a few individuals in the Middle East. A further colony with up to 100 individuals exists in Birecik, Turkey. Though these birds are a remnant of a former migratory colony that is now semi-captive, they...
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 9

 TERMINÉ 
The consortium has chosen the topic of circular economy (CE) as the focus of this project, because it concerns the transition from a take – make – use – dispose model that depletes natural resources and destroys ecosystems to a circular model where the value of products, materials and resources is maintained in the economy for as long as possible and the generation of waste is minimized. It has be...
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 11

 TERMINÉ 

Autologous Stem Cell Seeded Tissue Engineered Trachea (TETRA)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

CLINICAL PROBLEM AND UNMET NEEDThere are 11,827 patients with severe structural airway disease in Europe. Even with the current standard of care, when hospitalised this group of patients has a 22% risk of dying. Patients are currently subjected to repeated surgical interventions (stent insertion) which have a high failure rate. Other therapeutic strategies under development include synthetic trac...
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 14

 TERMINÉ 
STREAM is a 4-year multi-site training network that aims at career development of Early Stage Researchers (ESRs) on scientific design, construction manufacturing and of advanced radiation instrumentation. STREAM targets the development of innovative radiation-hard, smart CMOS sensor technologies for scientific and industrial applications. The platform technology developed within the project will b...
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 11

 TERMINÉ 

Algebraic Representations in Computer-Aided Design for complEx Shapes (ARCADES)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

ARCADES aims at disrupting the traditional paradigm in Computer-Aided Design (CAD) by exploiting cutting-edge research in mathematics and algorithm design. Geometry is now a critical tool in a large number of key applications; somewhat surprisingly, however, several approaches of the CAD industry are outdated, and 3D geometry processing is becoming increasingly the weak link. This is alarming in s...
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 9

 TERMINÉ 
The overarching goal of the project is to understand the economic, social, institutional and policy factors that have shaped the impacts of free movement and public debates about it. It aims to help European policymakers develop policy responses that inspire public trust, ensure the fairness and sustainability of free movement, and maintain inclusive policies that reduce inequalities across the co...
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 14

 TERMINÉ 

Advanced TeChnologies and PlatfoRm fOr Smarter ASsisted LivING (ACROSSING)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

Smart Home (SH) provides a promising approach to assisted living for the ageing population. Yet it still remains a challenge to develop and deploy such solutions in a large scale due to the lack of an easy-to-use technology infrastructure and application exemplars. This problem arises from the nature of the SH field: multidisciplinary, diverse in its applications, and with multiple stakeholders. W...
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 10

 TERMINÉ 
ProteinConjugates is an inter- and multi-disciplinary network for the education of talented young scientists who will learn how to rationally design and construct the next generation of chemically-defined and innovative protein drug-conjugates for the targeted treatment of serious conditions such as cancer or rheumatoid arthritis. A complementary interaction between academy and pharmaceutical indu...
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 8

 TERMINÉ 
The Wider objective of CONSEA is to ensure Biodiversity Conservation & Environmental sustainability around the Mekong River Basin. CONSEA consortium aims to develop a strong education program on biodiversity conservation in SEA. In spite of socio-economic difficulties of Cambodia and Vietnam, these countries are located in biodiversity hotspots. These territories endowed of added value are under c...
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 8

 TERMINÉ 

Global Studies - A European Perspective

Date du début: 1 oct. 2015, Date de fin: 30 sept. 2019,

Objective The objective of the Global Studies - A European Perspective Master Programme is to qualify students to deal responsibly and on an advanced scientific level with phenomena of globalisation and its accompanying processes in countries of the North and the South on the basis of findings, theories and methods from the Humanities and Social Science, History and Cultural Science.Course duratio...
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 8

 TERMINÉ 
In today’s translation industry, both quantitative and qualitative changes provide a challenge for higher education institutions that offer specialised translator training. These changes include an estimated annual market growth of 10 %, radical technological advancement and the dramatic change of the job profile ‘specialised translator’. However, a number of studies show that HE translator traini...
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 3

 TERMINÉ 

Lehrkompetenzentwicklung für extensiven Leseunterricht

Date du début: 1 sept. 2016, Date de fin: 31 août 2019,

Major aims of the ERASMUS+ project Developing Teaching Competencies for Extensive Reading Programs (LEELU) are to raise foreign language reading competencies of high-schools students and to test and improve a model of experience-based, cooperative and encompassing foreign language teacher education. LEELU’s starting point for pursuing these goals in innovative teacher education are the rather unsa...
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 4

 TERMINÉ 

Jean Monnet Chair of European Media Governance and Integration

Date du début: 1 sept. 2016, Date de fin: 31 août 2019,

EU issues are mostly addressed only from a legal angle.There is an urgent need for the provision of more education regarding EU issues. We aim to fill this gap on the basis of our multidisciplinary approach to European integration at the Media Governance & Industries Research Lab to serve professionals, civil society, the press and policymakers internationally. Freedom of Expression, Privacy, Copy...
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