The “Training health care teams in intercultural communication and patient safety” project addresses the complex issue of patient safety, failure of which results in millions of patient safety incidents each year, with severe consequences and unnecessary suffering for patients and their families as well as millions of public Euros in compensation. The project is a continuation of the other four projects carried out under the “Intercultural Education of Nurses in Europe” (IENE) topic initiative, which started in 2008 (www.ieneproject.eu). In order to match their skills to the competences demanded for safe patient care, this IENE5 project address the link between the levels of intercultural communication within members of MMHTs and patient safety and aims to increase the knowledge and skills of members of healthcare teams, in three major areas: Intercultural communication, Working in multicultural teams and Patient safety. Partners from five European countries, Universities (Middlesex University of London, UK , University College Lillebaelt, Denmark, Cyprus University of Technology, Nursing School Edunet, Romania and Azienda Ospedaliera Universitaria Senese, Italy bring relevant and complementary skills and human resources to create an innovative European Training Model, aiming to promote knowledge and skills of intercultural communication, working in MMHTs and patient safety and develop training content, learning and evaluation tools, which will be available on the project website. The partners will build a highly interactive and based on co-learning and co-creation MOOC (Massive Open On-line Course), containing learning and self-assessment activities and tools. After training 50 facilitators from the participating countries to support and guide the learners’ communities on the MOOC, 150 participants from the project’s partner countries and approximately 500 nurses and health care professionals from across the world will be recruited to participate in the training on the created MOOC. To promote the intercultural communication culture and patient safety values, six national seminars, will be organized in the partners’ countries attended by the managers, training providers and potential users, who will learn about the created resources and how to use and the MOOC. In carrying out the project, the pedagogical approaches we will use is innovative and learner-centered, based on digital integration in learning. The MOOC’s approach to learning is highly interactive and its underpinning philosophy is that of co-learning through co-creation. Our MOOC will mainly be provided in English with some translation and the students will be able to conduct their discussions, write their blogs and prepare their outputs in Romanian, Italian, Danish or Greek languages. The multilingual aspect of this MOOC will promote co-operation , communication, team working, respect of diverse opinions, sensitivity and tolerance to people from different cultures, backgrounds and increase language competence, digital skills, flexibility and creativity. The main outputs of the project are the Massive Open Online Course (MOOC) and the Open Educational Resources (OER), available on the project web site , www.ieneproject.eu : Report on the training needs, Innovative teaching and learning Model, Educational recourses, curricula and materials, Guide for facilitators, Brochure about the learning methodology using the MOOC . The nurses and healthcare professionals participating in the learning activities on the MOOC will have enhanced knowledge and skills about patient safety, deep appreciation of the benefits of effective communication and team work, confidence in dealing with patient safety. Our project will contribute to build culturally competent and compassionate teams. The learning which will occur during the MOOC should result in the reduction in patient safety incidents and thus reduction in patient harm and levels of compensation. This may result in higher levels of staff job satisfaction and improved quality of patient care. Our model, curriculum and learning/assessment tools will be embedded in the IENE platform and will be freely available to be used and also developed using creative commons license. The course modules, learning outcomes, learning activities, assessment methods, reading lists, suggested content and on-line resources and links to outside resources etc. can be used freely for distance learning or some parts of them may be used as portions of a conventional or blended training. It is anticipated that our innovative Model and the MOOC will become popular across Europe and continue to be provided by the partner organizations and be used by other organizations after the end of the project and the created resources may be adapted and set up new wider-ranging MOOCs for education processes across Europe.