Histological and cytological preparations are the basis for pathological diagnoses performed in daily practice throughout Europe in a number of several millions per year and correctness and reproducibility of such diagnoses is heavily dependent on the technical quality. Yet, quality is variable in different places and countries, related to school level, technicians’ dedication, standard of apparatuses and reagents. The present proposal tackles these problems by building-up an ICT environment TASTE System whereby technicians and students from different countries will submit via Web, using Tele-pathology procedures featuring “virtual slides”, the microscopic images of their own preparations to a panel of internationally-recognized experts who will give comments and suggestions. Practicing pathologists as well as Residents in Anatomic Pathology will be involved. Assessment with real users will be organized in order to smooth-down major problems encountered. Inter-laboratory transfer of sophisticated procedures will be favoured . The Exchange of images will start with basic routine stains (Haematoxylin-Eosin stained slides, Papanicolaou-stained smears) in order to check quality and reproducibility of fixation, processing and staining procedures. The program will then proceed with more sophisticated techniques such as immunohistochemical and FISH preparations. Ultimately, we expect that the present approach (unprecedented at world level) will fuel a Web-based community comprehensive of students and staff personnel, aimed to a levelling and improvement of histopathological and cytopathological preparations, thus leading to an innovative training and more reproducible diagnoses, a basic requisite for disease treatment.