“Talents for an International House” (TALENTS) has been designed for contributing to the overall objectives of the Specific Programme People and, in particular, of COFUND: in fact the creation of favourable conditions for the international mobility of highly skilled human resources, as well as for the inter-sectoral mobility represent its main factors. TALENTS is a Fellowships Programme developed by AREA, with the endorsement of the Regional Authority of Friuli Venezia Giulia, aimed at ensuring brain circulation and at combating fragmentation throughout Europe. The Programme involves a wide range of public and private scientific institutions operating in many different sectors (Chemistry, Material technologies, Nanotechnologies, Mechanical sciences, Genetic engineering, Biotechnologies and Diagnostic, Physics, Ecology and Environment, Oceanography, Marine biology, Information Technology and Multimedia). This scientific regional System is actually known throughout the world and constitutes a model in which university research, centres of excellence and technology transfer operators cooperate at a local, national and international level to produce, transfer and manage knowledge. The Programme includes both incoming mobility type and outgoing mobility one: the incoming fellows will work freely in the regional research institutions of their choice, even moving among the different institutions available, while the outgoing fellows will develop additional and complementary skills in a high level institution abroad, both in Europe and in a Third country. These fellows will be provided with suitable salaries and the most favourable working and living conditions. The Programme will guarantee freedom in choosing both the fellowship research topic and the hosting institution. Furthermore the trans-national and inter-sectoral characters of TALENTS offer the opportunity to enhance the researchers capabilities and to widen their future employability.