The Virtual Atomic and Molecular Data Centre (VAMDC) is a major new European initiative now building a unified, secure, documented, flexible and interoperable e-science environment-based interface to 17 existing A+M databases.The SUP@VAMDC (Support at VAMDC) aims at building upon the VAMDC e-infrastructure, supporting different studies and actions linked to the VAMDC e-infrastructure that will in accord with the mission of INFRA-2012-3.3:.•\tProvide operational, legal and technologicalsupport for studies aimed at developing a sustainable open scientific data e- infrastructure in Atomic and Molecular Data.•\tProvide the support and medium for including authentication, authorisation and accounting (AAA) as well as licensing and tools within the VAMDC brand•\tPromote and fashions future interoperability (technical, semantic, reference architecture, etc) across A&M data community through the promotion, monitoring and adoption of common standards.•\tProvide support for dissemination actions aimed at raising the visibility of the VAMDC e-infrastructure towards wider audiences such as other domains which could use the VAMDC e-infrastructure for their own science or for their own dissemination of data, such as students and/or citizen-scientists. This programme includes the development of education-related tools linking VAMDC's scientific repositories and research data infrastructures, including establishing a free open access repository containing all peer-reviewed articles resulting from the VAMDC programme.•\tProvide support in developing a globally connected and interoperable VAMDC e-infrastructure between EU and the rest of the world, including Brazil , South Africa, Asia, Australia, India through hosting workshops and supporting dialogue between such synergistic structures.•\tAnalyse and evaluate possible business models for supporting an Open Science model (OPEN VAMDC) whilst assessing the impact of such a modeling in achieving financial sustainability.