To achieve energy generation from sustainable resources the production of bio mass and the hydrogen economy are now featured worldwide with a tremendous effort. The processes for producing and cleaning of bio and hydrogen gas mixtures will be performed under elevated or high pressures. The design and performing as well as the control of those processes will generate an increasing demand for in Situ high pressure concentration measuring. Up to now no accurate instruments or even measuring methods are available for this purpose. To perform high pressure concentration measuring the usual treatment is to expand the fluid mixtures down to ambient or very low pressure, which has many disadvantages and may even be not possible in certain cases. The goal of the ProBio-HySens project is the development and combination of sensors for measuring optical, thermo physical and electro magnetic properties, to achieve an in Situ high pressure concentration measuring in bio and hydrogen gas mixtures. To reach this main goal the development of new high pressure in Situ sensors and of a high pressure Gas Mixture Generating and Sensor Calibration apparatus (GMG-SC) is required. This instrumentation will allow the first time to analyze multi component gas mixtures in Situ under process conditions up to 200 °C and 20 MPa may be even 50 MPa. It avoids devices for sampling, pressure reduction and control which have to be used up to now. Thereby no blocking of valves and tubings by condensation, freezing or precipitation will occur any more. More over it avoids sophisticated, time and cost consuming analyzers requiring intermediately high calibration efforts. The new senor modules will be robust and reliable and range between very economic versions to high end solutions. They will be specially tailored for bio and hydrogen gas mixtures but being also applicable to all other kind of fluid mixtures including super critical fluids if a pressure range up to 50 MPa is reached.