PSYCHE project will develop a personal, cost-effective, multi-parametric monitoring system based on textile and portable sensing platform for the long and short term acquisition of data.The patient diagnosed with bipolar disorder will be placed at the epicentre of its management, for treatment and prevention of depressive and manic episodes.The system will use wearable and portable devices for acquiring, monitoring and communicating physiological parameters, behavioural and mood correlated indexes (i.e. vital body signs, biochemical markers and voice analysis).The acquired data will be processed and analyzed in the established platform that takes into consideration the Electronic Health Records (EHR) of the patient, the parameters set up in the first stage between bipolar and non-bipolar individuals, as well as medical analysis in order to verify the diagnosis and help in prognosis of the illness.Finally communication and feedback to the patient will be performed through a direct contact with the patient and device, or by communication between physician and patient.Constant feedback and monitoring will be used to manage illness, to give patients support, to facilitate interaction between patient and physician as well as to alert professionals in case of patients relapse and depressive or manic episodes income.PSYCHE project will focus on the following objectives:i) Implementation of a sensing platform physiological and behavioural monitoring for patients with bipolar disordersii) Development of novel portable devices for the monitoring of biochemical markers, voice analysis and a behavioural index correlated to mental illnessiii) Brain functionality: in order to correlate central measures o with clinical assessment and the parameters measured by Psyche platformiv) Data mining and managing: The ultimate goal is to identify signal trends indicating detection and prediction of critical eventsv) The system will contain a patient and professional close loop