Euro-Mediterranean policies, as well as research on them, have been characterized by a Euro-centric approach based on a narrow geopolitical construction of the Mediterranean. Moreover, stakeholders, policy instruments, and policy issues have been defined from a European standpoint, marginalizing the perspectives and needs of local states and people, and ignoring the role played by new and powerful regional and global actors. In an increasingly multipolar world, overcoming this Euro-centric approach is key for Europe to play a more meaningful role in the region. Thus, MEDRESET aims to reset our understanding of the Mediterranean and develop alternative visions for a new partnership and corresponding EU policies, reinventing a future role for the EU as an inclusive, flexible, and responsive ‘actor’ in the region. This will be achieved through an integrated research design which is in three phases: it 1) de-constructs the EU construction of the Mediterranean, 2) counters it by mapping the region on the geopolitical level and in four key policy areas (political ideas, agriculture and water, industry and energy, migration and mobility) alongside a three-dimensional framework (stakeholders, policy instruments, policy issues), which directly feeds into 3) a reconstruction of a new role for the EU, enhancing its ability to exert reflexive leadership and thus its relevance in the region. Embedded in an interdisciplinary research team, as well as in a civil society and media network, MEDRESET evaluates the effectiveness and potential of EU policies by investigating whether current policies still match the changing geopolitical configuration of the Mediterranean area. The perceptions of EU policies and the reasons for their successes or failures are assessed by surveying top-down and bottom-up stakeholders on both shores of the Mediterranean. Country-tailored policy recommendations for the EU will be given for four key countries: Egypt, Lebanon, Morocco, and Tunisia.