Up2Europe est un accélérateur d’idées pour des projets de coopération.
La plateforme Ma Région Sud fait partie de l'écosystème de Up2Europe qui permet de booster la coopération à un niveau supérieur!
Besoin d'aide ? La Région Sud vous accompagne
Laissez-vous guider par notre équipe d'experts ! Saisissez votre mail et nous reviendrons vers vous rapidement
Mathematical modeling of anaesthetic action (MATHANA)
Mathematical modeling of anaesthetic action
(MATHANA)
Date du début: 1 janv. 2011,
Date de fin: 31 oct. 2015
PROJET
TERMINÉ
General anaesthesia is an important method in today's hospital practice and especially in surgery. To supervise the depth of anaesthesia during surgery, the anaesthesist applies electroencephalography (EEG) and monitors the brain activity of the subject on the scalp. The applied monitoring machine calculates the change of the power spectrum of the brain signals to indicate the anaesthetic depth. This procedure is based on the finding that the concentration increase of the anaesthetic drug changes the EEG-power spectrum in a significant way. Although this procedure is applied world-wide, the underlying neural mechanism of the spectrum change is still unknown. The project aims to elucidate the underlying neural mechanism by a detailed investigating a mathematical model of neural populations.The investigation is based on analytical calculations in a neural population model of the cortex involving intrinsic neural properties of brain areas and feedback loops to other areas, such as the loop between the cortex and the thalamus. Currently, there are two proposed mechanisms for the charactertisic change of the power spectrum: a highly nonlinear jump in the activation (so-called phase transition) and a linear behavior. The project mainly focusses on the nonlinear jump to finally rule it out or support it. A subsequent comparison to previous experimenta results aims to fit the physiological parameters. Since the cortex population is embedded into a network of other cortical areas and the thalamus, the corresponding analytical investigations takes into account external stochastic (from other brain areas) and time-periodic (thalamic) forces. To this end it is necessary to develop several novel nonlinear analysis technique of neural populations to derive the power spectrum close to the phase transition and conditions for physiological parameters.
Accédez au prémier réseau pour la cooperation européenne
Se connecter
DOMAINE DE VOLUCEAU ROCQUENCOURT
78153 LE CHESNAY CEDEX
(France)
Bonjour, vous êtes sur la plateforme Région Sud Provence-Alpes-Côte d’Azur dédiée aux programmes thématiques et de coopération territoriale. Une équipe d’experts vous accompagne dans vos recherches de financements.
Contactez-nous !
Contactez la Région Sud Provence-Alpes-Côte d'Azur
Vous pouvez nous écrire en Anglais, Français et Italien