NanoHOUSE intends to create a holistic and prospective view on the Environmental Health and Safety (EHS) impacts of nanoproducts used in house building, namely paints and coatings. The latter are using relatively high amounts of Engineered NanoParticles (ENPs) such as nano-Ag and nano-TiO2 which will be investigated. A new Life Cycle Thinking (LCT) approach will be developed gathering two complementary aspects: Investigation of risks and opportunities during the product life cycle as well as Life Cycle Analysis (ISO 14040). LCT will collect information on EHS impacts throughout all life cycle stages of the nanoproducts, identifying the data gaps which will guide the research work. NanoHOUSE will generate reliable scientific information for the missing data and will develop appropriate methods to analyze the potential EHS impacts of nanoproducts. NanoHOUSE first task will be to quantify the actual sources of ENPs during the use and ageing of actual coatings (weathering, renovation, demolition and final disposal). The project will then characterize the environmental compartments significantly impacted by ENPs released from nanoproducts, measure ENPs concentrations and states in those compartments, and investigate their fate in order to increase the knowledge regarding exposure to ENPs with a view to reducing the risks. NanoHOUSE will study the environmental behaviour and the toxicological effects of actually released ENPs (“aged” ENPs) and compare them with pristine ENPs. Finally, NanoHOUSE will improve the solutions for end of life treatments regarding ENPs release in the environment. Main outcomes of the project will be a scientific risk evaluation of nanoproducts used in building, solutions to improve their competitive and sustainable development by decreasing their potential to release ENPs, and contributions to standard tests for their certification. The NanoHOUSE consortium involves 5 research/academic partners and 4 industrial manufacturers of which 1 SME.