The project concept is to combine nanoreactor technology with multisite solid catalyst design to achieve a safer, cleaner and intensified chemical production. The project ideas are the following: (i) From micro- to nano-reactors. Actual microreactor have channels of micrometric size. We will develop a new concept based on the use of nanometric size channels. (ii) Vectorial pathway for multisite catalytic reactions. A limit in cascade (or domino) reactions is that there is no possibility to control the sequence of reactions of transformation of a reactant in a multisite catalyst. The concept of vectorial pathway for multisite catalytic reactions is based on the idea of an ordered sequence of catalytic sites along the axial direction of the channels of a membrane, in order to control the sequence of transformation. (iii) Dynamic nanoreactor. The concept of dynamic nanoreactor is based on the transient generation of toxic reactants inside the nanoreactor and the immediate conversion, in order to eliminate the storage of these reactants (which is minimized, but not eliminated in on-site or on-demand approaches). The project concept is that the implementation of innovative and safer pathways for sustainable chemical production requires making a step forward in the development of catalyst-reactor design along the lines indicated above. The project applies above ideas to three reactions of synthesis of large-volume chemicals which are relevant example of innovative pathways for sustainable chemical production: (1) direct synthesis of H2O2, (2) PO synthesis with in-situ generated H2O2 and (3) solvent-free synthesis of DPC with in-situ transient generation of phosgene. The consortium has a clear industrial leadership, with sixth major companies and two SMEs, and four academic partners, plus the participation of the durable institution of the NoE IDECAT.