Background The REACH Regulation (1907/2006/EC) aims to protect human health and the environment, by targeting the movement of substances, on their own, in mixtures or in articles, while enhancing competitiveness and innovation. Its aim is to ensure that goods imported into the EU undergo the same checks as equivalent goods produced within the EU territory. REACH includes the requirement for producers and importers of chemicals to prove that their substances are safe before they can be placed on the market, but its application is not sufficiently harmonised to ensure consistently reliable information on imported substance identity, registration status or safety. There is a need for better information to be made available concerning the impact of many chemicals present in these goods, their correct usage, and on the exposure arising from their downstream use. Furthermore, the establishment of liability in relation to the marketing and use of imported dangerous chemicals needs to be clarified. Objectives The overall objective of the LIFE+ inREACH project is to improve the protection of health and the environment by facilitating information exchange on chemicals imported into the EU and their compliance to the REACH Regulation, by means of innovative solutions with a public dimension. The project’s specific objective is to streamline REACH and CLP (Classification, Labelling and Packaging) compliance checks for goods imported into the European Economic Area and the EU customs space, by simplifying access to and tracking of relevant REACH and CLP information, such as substance identity, registrant identity, substance registration status, safety datasheets and the presence of SVHCs. A more efficient collection and sharing of data on origin and destination of REACH and CLP-related goods for customs and enforcement authorities will facilitate transit through EU main access points, while ensuring proper data security and correct policies of access to them, in order to preserve confidentiality, industrial and intellectual property rights. Expected results: Overall evaluated reduction by 5-10% of actual unsafe chemicals entering into EU space/mobilisation/use; Improved science-policy integration and the transfer of results to provide a solid technical background for public bodies, authorities and the business community affected by the REACH Regulation Framework; A national thematic stakeholder’s platform established with links to relevant EU authorities and agencies to support project actions; Consolidation of the inREACH Framework and identification of the 25 most critical issues affecting REACH Regulation implementation; A roadmap for the definition of strategies and activities to overcome the 25 most critical issues affecting REACH Regulation implementation; Technical specifications for an operations and process model, supported by an ICT platform, to check compliance of chemicals with the REACH Regulation at the EU import stage; Demonstration of the exploitability, viability and sustainability of the developed inREACH Framework at national level and its replicability potential at EU level; Improvement through inREACH Framework of the evaluation of actions relating to REACH/CLP administrative information and chemical safety information and improved tracing through iRCApp of initial information entered into the system and its confrontation with information transferred to authorities and downstream users (DUs); Non-conformity comparison between actual REACH/CLP compliance information and the ones gathered, verified and shared; Updated and extended list of potential critical issues arising from occurrence of certain substances, such as CMR, PBT and vBvP; and Increased capacity to identify potential substances of very high concern (SVHC) for consumers and environment.