"HEREPLUS will: 1) involve coordination among epidemiologists, biostatisticians, environmental scientists, GIS specialists in order to realize the full potential of GIS technology in environmental health research; 2) develop risk maps relating to human health, and O3 and PM concentrations using the ArcGis approach, taking into account existing and validated epidemiological models, for selection of important and problematic large European urban areas such as Rome, Madrid, Dresden, Athens; 3) improve the knowledge of the potential role of different urban vegetation types for mitigating the O3 and PM pollution levels, and provide best practices regarding the selection of no-VOCs emitting species and management of large green areas located in different neighbouring urban areas; 4) furnish guidelines for municipal managers and administrators deputed to establish urban-environmental measures which combine risk maps, urban vegetation as a sink for ozone and PM, and minimization of sanitary costs, all based on results and knowledge achieved by the project activities as a whole. These guidelines will take the form of best practices recommendations and designs for municipal laws that may be used as a base-line for municipal administrations; 5) disseminate guidelines and best practice indications at a European level, through international workshops and a conclusive report. Specific cardio-respiratory disease, such as asthma, bronchitis, COPD exacerbation, ischemic heart disease, and the morbidity and mortality for these diseases, associated to O3 and PM, will be considered in HEREPLUS. HEREPLUS will produce the above mentioned risk maps starting from pre-existent environmental and health data, by development of new epidemiological and statistical approach, also in support for the implementation of Global Earth Observation System of Systems (GEOSS) initiative and the Environment and Health Action Plan."