Description Traumatic brain injury (TBI) occurs when a sudden trauma causes damage to the brain – it is a major health problem and the most common cause of permanent disability in people under the age of 40 years. Yearly cost from TBI in Europe exceeds 100 billion euros. Recent statistics show a steep increase in the incidence of TBIs, with an increase of 21 % over the last five years – threefold greater than the rate of increase in population. Despite this TBI has been seriously underrepresented in medical R&D efforts.The TBIcare project aims to improve TBI diagnostics and treatment decisions for every individual patient. To do that, the project researchers are developing a software solution to be used in daily practice. Part of this tool are 1) a methodology for finding efficient combinations of multi-modal biomarkers used in statistical models to objectively diagnose and assess a TBI patient, and 2) a simulation model for objectively predicting outcome of the planned treatment of a TBI patient. TBIcare has impacts for healthcare professionals by improving the healthcare process and increasing medical knowledge; for the patients and their nearest by increased quality adjusted life years; for society it brings reduction in healthcare costs and losses due to working disability, and for the European industry it brings an impetus to increased global competitiveness by providing immediately exploitable innovative methods.