Ongoing curriculum renewal is an essential element of modern medical education. Increasingly, it is recognised that specialist educators and educational units enhance development and embedding of new curricula. Post–Soviet medical education, which remains teacher-based and classroom-orientated, would benefit greatly from this enhancement.This consortium proposes the creation of national medical education centres (MECs) in GR, UA, KZ. Their initial task is to modernise the teacher-based and classroom-orientated biomedical science component of the medicine course in 6 universities in the PCs, moving to more student-motivating, competency-based learning styles than exist currently, and which are more relevant to clinical practice. To this end, the curricula will move to more enquiry-based learning, i.e. Problem Based Learning (PBL), where students work in teams to explore a patient case or problem.Recently curricula have benefited from technological developments to introduce interactive forms of PBL using ‘virtual patients’, which are closely aligned with modern student behaviour and experience, and provide a game–informed, media-saturated environment. These allow students to consider different options as an interactive case unfolds, take decisions, and explore the consequences of their own patient management.The outcome of modernisation will be curricula that more closely mirrors clinical practice; students learn in the way they will practice, and will be assessed in the way that they learn.MECS will continue as foci of curriculum development. To generate the critical mass of academics/institutions needed for sustainability, the MECs, CY and EL will link with medical education networks with similar needs for continued modernisation and cultural preservation e.g. the Czech/Slovak MEFANET, the mEducator(AUTH), eViP (SGUL) and other local EC projects. This ‘ePBLnet’ will be used to sustain the MECs with self-funded ePBLnet conferences, workshops and services.