Dual-Imaging Nano/Micro-sized Theranostics (against cancer)
Date du début: 1 août 2013,
Date de fin: 31 juil. 2016
Objectives of the joint exchange program “DINaMiT” is to develop state-of-the art remotely responsive magnetic/metal nanoparticle functionalized drug delivery carriers for dual optical and magnetic resonance imaging modalities, equip such probes with theranostic detection/delivery capabilities and apply them for in-vivo study of anticancer drugs. To implement ambitious goals of such a program seven work-packages will be pursued. Each work-package will constitute of a necessary step for reaching the milestones and overall goals of the exchange programme.Functionalization of delivery carriers by nanoparticles is an important issue of successfully achieving the goals of the project. Optical imaging is the technique of choice for working with cell cultures and for routine fluorescent sample characterization. A significant advancement of the scientific research program is addition of magnetic response capabilities for such carriers, which results into dual optical / magnetically responsive system. Functionalized by nanoparticles, delivery carriers can be remotely activated based on the localized heating, which induces the permeability change of the carriers, but which does not affect the surrounding tissue. We envision using two-photon microscopy for deeper in-tissue reach. Magnetic functionality is viewed as a complementary approach which will allow even deeper reach. Magnetic resonance imaging (MRI) is a technique widely used for in-vivo diagnostic and tracking investigation.Polymeric and natural (red blood cells) delivery vehicles will be used for assembling ther-anostic carriers. Theranostic functionalities will be introduced by assembling the so-called multicompartment structures. Indeed, after such carriers are assembled and imaging/activation system is developed, in-vitro as well as in-vivo applications of such a system will be pursued. For in-vitro applications cell culture tests will be used, while that will be transferred for real in-vivo applications.
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