FASHION-ABLE project aims at providing the European innovative and customization-concerned SMEs with the technological means that will enable the agile and eco-efficient production of personalised products addressing the complex individualised needs of growing market niches out of the scope of mass-produced goods in terms of health and performance. FASHION-ABLE vision is to provide the innovative European SMEs concerned in customization with the technological means that will enable the conception, co-design and the sustainable manufacture of fully personalised products. The expected results of the project are: User framework defining and quantifying the relevant user attributes; new Collaborative Product Customization Services; New stretch-leather’s lean manufacturing processes and equipment; new 3D-spacer fabric’s flexible manufacturing process and machinery; new textile’s finishing operations and equipment; extended manufacturing order management structure and tools; Life-Cycle Analysis instruments; and inter-organisational Product Data Management tools. In particular, FASHION-ABLE action will implement and demonstrate in industrial contexts the new cross-sectoral technologies developed for three highly challenging target groups: fashionable footwear for diabetic feet, fashionable clothing for wheelchair users, high-performing textile compression bandages. The harmonized combination of these technologies will have a direct impact on health, comfort, safety and quality of life of the targeted populations: diabetics developing diabetic feet (30 million); physically disabled people requiring a wheelchair (5 million); and sufferers from acute periods of musculoskeletal disorders (40 million) which prevalence increases with age and weight. Furthermore, our cross-sectoral approach will allow extending and up-scaling functional customisation with little effort to future unexpected functionalities and to be transferred to other products and high demanding markets.