"The main aim of this project is the development of a new technology to produce smart drug deliverysystem for chemotherapeutic agents per recognition event. For that affinity-microparticles (10-20 micronsdiameter) loaded of paclitaxel (PTX) or Endotastin will be produced.Microcapsules will be made using a new technology based on the formation of drops from viscous non-Newtonian liquids sprayed through fan-jet nozzles. This process is based on generation of kinetic energy to aliquid jet resulting on controlled spray generation. The technique will be modelled in order to ensure the scale-upthe process.The microparticles, based on alginate polymer, will be functionalised on his surface by affinity ligand, epidermalgrowth factor (EGF) which will be able to recognize a specific protein of the tumoral cell, (EGFR) epidermalgrowth factor receptor.Surface plasma resonance will be carried to control the interaction between the microparticle and the protein andtherefore to ensure the efficiency of the microparticles produced. This information will be used to developed adynamic model to assess the importance of spatial phenomena and then we will evaluate the accuracy of partialdifferential equations (PDEs) in transient when spatial effects are important.Control release from microcapsules loaded of anticancer agent will be characterized by control release kinetics,mass transfer, mechanic stability and permeability studies. Mass transfer through the tissue, or therapeuticleakage from storage cavities and their consequent transport through the organ, are among the several physicalprocesses, where knowledge of the unsteady transport of a scalar quantity (mass of an active) is of importancefor cell therapy. For that reasons it is necessary to derive an analytical solution for the unsteady mass transportproblem in a porous medium under torsional flow to simulate the diffusion of active materials in body cavities(Mixed mechanic-electrical model), assuming body cavities as ideally isotropic porous medium.Finally, characterized microcapsules will be tested in lung tissues with lung cancer. Cell viability (MTT) andapoptosis after PTX exposure in non small cell lung cancer (NSCLC) will be studied. Morphological distributionof particles in areas of interest (lung, pleura and lymph nodes) will be examined. The experimental results foundin vitro will compared with experimental animal models developed for tumoral cell death."