The overall aim of this project is to synthesise and fully characterise new asymmetric functionalised nanowires and to investigate the capability of these fascinating materials to act as therapeutic transportation tools in nanomedicine. Given suitable choice of materials these “NanoMotors” can be displaced via catalytic decomposition of a fuel which leads to self electrophoretic propulsion towards one end of the nanowire. The unique features of these nanodevices will be tested for the directed delivery of “clot buster” drug cargos. Such nano delivery systems aim to render delivery specifically to the site of disease, improving stability, loading and bioavailability of their cargos. The provision of the human infrastructure requested here with essential background knowledge and expertise will contribute towards development of this emerging area within Europe. Our findings will have an impact on related fields such as nanosensors, material science and nanomedicine.The core objectives are:1. Synthesis of modified nanowires enabling guided motion along a predetermined pathway.2. Full characterisation of the nanomotors using advanced surface techniques and catalytic propulsion testing.3. Bio-conjugation studies and assessment of protein binding and release options.These objectives will be achieved using innovations and tasks involving the use of specialist resources and techniques within the physical and surface sciences, which are available at the host institution at ITT Dublin. It is envisaged that this project will facilitate key knowledge transfer from Dr. Krishnakumar Pillai (an experienced researcher from India who is working in field of nanobiotechnology) to the host institution in Ireland. The research group involved has a proven capacity to absorb, retain and exploit such knowledge by appropriate means, bringing adding value and increased potential for international collaboration via spin-off projects in related areas.