"Modern Networked Critical Infrastructures (NCIs), e.g. the electrical grid, rely on Information and Communication Technologies (ICT) for their operation since ICT can lead to cost reduction as well as greater efficiency, flexibility and interoperability between components. In the past NCIs were isolated environments and used proprietary hardware and protocols, limiting thus the threats that could affect them. Nowadays, with the adoption of Commercial Off-The-Shelf (COTS) ICT, NCIs are exposed to significant cyber threats that can lead to economical and human losses.To address the aforementioned issues, this project aims at elaborating novel holistic methodologies for the design of security and resilience-aware ICT infrastructures for NCIs. The project will develop state-of-the-art techniques and tools to aid engineers in designing secure and resilient industrial ICT-based installations.The novelty of the project consists in the fact that it will fuse together the cyber and physical dimensions of NCI, an important aspect that is missing from existing approaches. The project will create novel NCI network design techniques by solving multi-criteria optimization problems that take into account several aspects such as NCI design standards, e.g. NIST SP 800-82 and NERC CIP 002-009, resilient operation of physical process, but also installation-specific information, e.g. geographical aspects. The project will also provide more effective protection mechanisms, e.g. cyber-physical Intrusion Detection Systems, by combining data from cyber and physical sensors.The proposed research lies in the context of the ""European Programme for Critical Infrastructure Protection"" (EPCIP), the ""Critical Information Infrastructure Protection"" (CIIP) action plan and the ""Digital Agenda for Europe"" (DAE) by addressing key security and resilience issues of NCIs that will ultimately lead to the better protection of existing and future Critical Infrastructures."