"The European Commission has identified poor diets and low physical activity levels as health challenges wich should be adressed by actions across policy areas and engaging a range of public and private actors. Research points to a necessary link between nutrition and physical activity, but regional health economies need better collaboration between triple-helix actors to tap this potential.This project aims at developing a research agenda for reducing diet- and physical inactivity-related (chronic) diseases, such as diabetes, obesity, cardiovascular diseases and various types of cancer, by developing innovative products and services within the field of nutrition and physical activity. Instrumental for this is collaboration on a EU wide platform for new research and innovation in the combined field of healthy food and physical activity.The novelty lies in a multidisciplinary approach closing the gap between regional economic hotspots related to food and physical activity. Following this logic they chose the acronym ""AFRESH - activity and food for regional economies supporting health"".Novel is also the fact that highly competitive RDCs undertake mentoring activities to help those to “get on board” where the collaboration within the triple-helix is insufficient.Finally, the project is novel in the actions which will be implemented: ‘AFRESH Ideas’ research and product concepts and a Change Management Toolkit for mentoring regions."