ESFRI initiatives with a need to work on a global scale will have to collaborate with international comparable partners. The CReATIVE-B project will seek to support the interaction between the LifeWatch ESFRI Research Infrastructure with RI on biodiversity and ecosystems research in other parts of the world. The immediate objective is to define a road map for interoperability on the technological level, on the governance level and on the interrelation with the scientific communities using the RIs. The project will therefore be a catalyst for worldwide collaboration in this field by supporting and initiating coordination activities of these RIs. The greater objective of this collaboration is to serve the goals of GEOSS. At the same time, the international outreach of LifeWatch can lead to further international collaboration on interoperability of these infrastructures to even better serve research communities worldwide. In order to do so, CReATIVE-B will initiate with the international 'sister' infrastructures to have a second edition of the e-Biosphere conference, to be organized in 2013, and contribute to this conference. In achieving the goals of this coordination and support action, CReATIVE-B will further support the European Commission flagship, vision 2020.