Code-engineered new-to-nature microbial cell factories for novel and safety enhanced bio-production
(METACODE)
Date du début: 1 déc. 2011,
Date de fin: 30 nov. 2015
PROJET
TERMINÉ
The concept of METACODE is to preform genetic code engineering in microbial strains with parallel recruitment of novel bio-orthogonal chemistries for mass production of desired protein/peptide based products. In combination with computational and classical chemical synthetic approaches as well as chemo-informatics, enzyme guided evolution, synthetic metabolism, and directed evolution of microbial strains, artificial industrial microbial strains will be designed. This will enable the access to genetically robust and safe strains with added/novel functionalities and topologies from renewable resources. These strains will be characterized with alternative reading of the genetic code (genetic firewall) and with predetermined chemistries (metathesis), as well as necessary robustness for efficient industrial use.
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Coordinateur
TECHNISCHE UNIVERSITAET BERLIN
€ 898 809,00- Silke Hönert
- STRASSE DES 17 JUNI 135 10623 BERLIN (Germany)
Details
- 77% € 2 996 938,00
-
FP7-KBBE
- Projet sur CORDIS platform
7 Participants partenaires
UNIVERSITAT BASEL
€ 249 600,00- Thomas Ward
- PETERSPLATZ 1 4051 BASEL (Switzerland)
- Mathilde Suret
- RUE LEBLANC 25 75015 PARIS 15 (France)
Molecular Networks GmbH – Computerchemie
€ 241 200,00- Johann Gasteiger
- Henkestrasse 91052 Erlangen (Germany)
Isthmus
€ 343 992,00- Pierre Dedenys
- Rue Saint Amand 31 75015 Paris (France)
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
€ 499 237,00- Sven Panke
- Raemistrasse 101 8092 ZUERICH (Switzerland)
KATHOLIEKE UNIVERSITEIT LEUVEN
€ 250 000,00- Sarah Malevé
- Oude Markt 13 3000 LEUVEN (Belgium)
BIOFACTION KG
€ 264 320,00- Markus Schmidt
- KUNDMANNGASSE 39/12 1030 WIEN (Austria)