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Catalytic asymmetric synthesis of amines and amides (CASAA)
Date du début: 1 déc. 2012, Date de fin: 30 nov. 2017 PROJET  TERMINÉ 

"Amines and their acylated derivatives – amides – are among the most common chemical functional groups found in modern pharmaceuticals. Despite this there are few methods for their efficient, environmentally sustainable production in enantiomerically pure form. This proposal seeks to provide new catalytic chemical methods including 1) the catalytic, enantioselective synthesis of peptides and 2) catalytic methods for the preparation of enantiopure nitrogen-containing heterocycles. The proposed work features innovative chemistry including novel reaction mechanism and catalysts. These methods have far reaching applications for the sustainable production of valuable compounds as well as fundamental science."