Rechercher des projets européens

This project aims to unravel the molecular architecture of the structural components of the presynaptic terminal of hippocampal neurons grown in culture and to elucidate their functional properties. These are closely related to the synaptic vesicle release, one of the central questions in synaptic function, as well as with the development and maturation of synapses. The investigation of the struct ...

"In eukaryotes, nuclear pore complexes (NPCs) are large assemblies that selectively transport cargoes across the nuclear envelope. Determination of the architecture of the NPC in molecular detail is central to understanding nuclear transport. Structural analysis of the NPC is a major challenge given its sheer size and its dynamic nature. Cryo-electron tomography (cryo-ET) has successfully been use ...