39 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Photoinduced Catalysis in a Nanoparticle System (PHOTOCAT)
Date du début: 1 nov. 2009, Date de fin: 31 oct. 2013,
...ed instantaneously and into a precise location. In order to render NPs photoactive, their surfaces need to be functionalized with photoresponsive ligands. As an incoming Independent Researcher at the Weizmann Institute of Science, the Applicant wishes to develop new nanomaterials resulting from this marriage of nanoscience and organic chemistry. The Applicant has extensive experience in the fields ...
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1
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TERMINÉ
Analysis of controllability and control landscapes for quantum systems (ACOLA)
Date du début: 12 juin 2011, Date de fin: 11 juin 2013,
...ly analytical and numerical tools to quantum control problems that are at the forefront of research in physics and chemistry.The project will be performed in the research group of Prof. Tannor at the Weizmann Institute of Science. It will contribute significantly to European excellence and competition in the field of quantum control through transferring knowledge and research expertise of Dr. A. P ...
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1
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TERMINÉ
Uncovering the Mechanisms of Epigenetic Reprogramming of Pluripotent and Somatic Cell States (CELLREPROGRAMMING)
Date du début: 1 nov. 2011, Date de fin: 31 oct. 2016,
...n disease specific research. In this ERC Starting Grant proposal, I describe comprehensive lines of experimentation that I plan to conduct in my new lab scheduled to open in April 2011 at the Weizmann Institute of Science. We will utilize exacting transgenic mammalian models and high throughput sequencing and genomic screening tools for in depth characterization of the molecular “rules” of rewirin ...
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1
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TERMINÉ
Interaction of Nonlinearity and Disorder: Gateways to Optics (INDIGO)
Date du début: 1 avr. 2013, Date de fin: 31 mars 2015,
...eeks to train an experienced researcher (Dr Stanislav Derevyanko) to the highest level of professional competence by bringing him into a world class research group in the field of nonlinear optics at Weizmann Institute of Science (Israel). This goal will be acheived by an ambitious research programme aimed at elucidating the nature of the complex interplay between nonlinearity and disorder using ...
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TERMINÉ
Assessing the Effects of Rising O2 on Biogeochemical Cycles: Integrated Laboratory Experiments and Numerical Simulations (AEROBIC)
Date du début: 1 sept. 2013, Date de fin: 31 août 2018,
...ocean chemistry and the rise of O2. An ERC Starting Grant will enable me to use the excellent experimental and computational facilities at my disposal, to access the outstanding human resource at the Weizmann Institute of Science, and to address one of the major open questions in modern geochemistry.
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TERMINÉ
Bloom the Dry. The Creation of Traditional Mediterranean Irrigated Fields (DryIR)
Date du début: 1 sept. 2015, Date de fin: 31 août 2017,
...e València and Pla de la Vila (Spain). The integration of geoarchaeological methods with the techniques that will be acquired at the host institution, the Kimmel Center for Archaeological Research, Weizmann Institute of Science, Israel (infrared spectroscopy and phytolith concentration quantification analyses) will allow me to study the genesis of traditional irrigated fields from an interdiscipli ...
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2
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TERMINÉ
Generation of Non-classical States in Optomechanical Systems (GeNoSOS)
Date du début: 1 juin 2016, Date de fin: 31 mai 2018,
...roduced many milestone results in the field, which are now highly cited papers.The applicant, Itay Shomroni, has a proven track record in cavity QED and atomic physics, having done his PhD at the Weizmann Institute of Science, Israel, and is first author on Science, Nature Physics and PRL papers. His move into this emerging field at the interface of quantum optics and atomic and condensed matter p ...
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1
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TERMINÉ
Neural basis of natural navigation: Representation of goals, 3-D spaces and 1-km distances in the bat hippocampal formation – the role of experience (NATURAL_BAT_NAV)
Date du début: 1 nov. 2016, Date de fin: 31 oct. 2021,
... rodents and bats navigate over kilometer-scale distances. Nothing is known about how the brain supports such real-life navigation. We will utilize a 1-km long test facility at the Weizmann Institute of Science, and record place cells and grid cells in bats navigating over biologically relevant spatial scales. Further, we will compare neural codes for space in wild-born bats versus bats born in t ...
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1
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TERMINÉ
Cracking the epitranscriptome (CrackEpitranscriptom)
Date du début: 1 nov. 2016, Date de fin: 31 oct. 2021,
Over 100 types of distinct modifications are catalyzed on RNA molecules post-transcriptionally. In an analogous manner to well-studied chemical modifications on proteins or DNA, modifications on RNA - and particularly on mRNA - harbor the exciting potential of regulating the complex and interlinked life cycle of these molecules. The most abundant modification in mammalian and yeast mRNA is N6-meth ...
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1
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TERMINÉ
Host-virus chemical arms race during algal bloom in the ocean at a single cell resolution (Virocellsphere)
Date du début: 1 nov. 2016, Date de fin: 31 oct. 2021,
Phytoplankton blooms are ephemeral events of exceptionally high primary productivity that regulate the flux of carbon across marine food webs. The cosmopolitan coccolithophore Emiliania huxleyi (Haptophyta) is a unicellular eukaryotic alga responsible for the largest oceanic algal blooms covering thousands of square kilometers. These annual blooms are frequently terminated by a specific large dsDN ...
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1
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TERMINÉ
New Directions in Sustainable Catalysis by Metal Complexes (SUSCAT)
Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,
The discovery of novel sustainable catalytic reactions is a major current goal. Based on recent discoveries in our group, we plan to develop unprecedented sustainable catalytic reactions with special emphasis on reactions catalyzed by complexes of earth-abundant metals.We have recently discovered an intriguing reaction, namely the oxidation of organic compounds using water, with no added oxidant, ...
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1
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TERMINÉ
Beyond CRISPR: Systematic characterization of novel anti-phage defense systems in the microbial pan-genome (PhageResist)
Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,
The perpetual arms race between bacteria and phage has resulted in the evolution of efficient resistance systems that protect bacteria from phage infection. Such systems, which include restriction enzymes and CRISPR-Cas, have major influence on the evolution of both bacteria and phage, and have also proven to be invaluable for molecular and biotechnological applications. Although much have been le ...
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1
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TERMINÉ
Quantum fluids of photons in optically-induced structures (Q-PHOTONICS)
Date du début: 1 juin 2016, Date de fin: 31 mai 2021,
A variety of classical optical systems exhibiting rich and complex matter-like behavior have been explored in recent years. Unfortunately in the optical regime, photons – the fundamental constituents of light – do not interact strongly with one another, and therefore cannot be used for studying many-body effects. It is only in the extreme regime of quantum nonlinear optics where effective interact ...
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1
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TERMINÉ
Extremes in logarithmically correlated fields (LogCorrelatedFields)
Date du début: 1 juin 2016, Date de fin: 31 mai 2021,
The proposed research deals with the extremes of logarithmically correlated fields, in both the Gaussian and non-Gaussian setups. Examples of such fields are branching random walks, the (discrete) two dimensional Gaussian free field, the set of points left uncovered by a random walk on the two dimensional torus at times close to the cover time of the torus, the (absolute) values of the characteris ...
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1
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TERMINÉ
Revealing the ubiquitin and ubiquitin-like modification landscape in health and disease (Ubl-Code)
Date du début: 1 mai 2016, Date de fin: 30 avr. 2021,
Post-translational modifications (PTMs) of proteins are a major tool that the cell uses to monitor events and initiate appropriate responses. While a protein is defined by its backbone of amino acid sequence, its function is often determined by PTMs, which specify stability, activity, or cellular localization. Among PTMs, ubiquitin and ubiquitin-like (Ubl) modifications were shown to regulate a va ...
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1
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TERMINÉ
Cellular Dynamics of Intestinal Antibody-Mediated Immune Response (GutBCells)
Date du début: 1 mai 2016, Date de fin: 30 avr. 2021,
Vaccination is widely used to prevent human diseases by inducing the formation of cellular and antibody-mediated immune responses for induction of long lasting immunological memory. Although most studies focus on immune responses elicited against injected immunizations, the simplest delivery of a vaccine regimen is by oral administration. The cellular and molecular components of the antibody immun ...
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1
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TERMINÉ
Genetically Encoded Multicolor Reporter Systems For Multiplexed MRI (GeneREFORM)
Date du début: 1 mai 2016, Date de fin: 30 avr. 2021,
In order to fully understand the complexity of biological processes that are reflected by simultaneous occurrences of intra and inter-cellular events, multiplexed imaging platforms are needed. Fluorescent reporter genes, with their “multicolor” imaging capabilities, have revolutionized science and their founders have been awarded the Nobel Prize. Nevertheless, the light signal source of these repo ...
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1
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TERMINÉ
Colloidal Quantum Dot Quantum Optics (ColloQuantO)
Date du début: 1 mai 2016, Date de fin: 30 avr. 2021,
Colloidal semiconductor nanocrystals have already found significant use in various arenas, including bioimaging, displays, lighting, photovoltaics and catalysis. Here we aim to harness the extremely broad synthetic toolbox of colloidal semiconductor quantum dots in order to utilize them as unique sources of quantum states of light, extending well beyond the present attempts to use them as single p ...
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1
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TERMINÉ
Genetic and Small Molecule Modifiers of Lysosomal Function (LysoMod)
Date du début: 1 mars 2017, Date de fin: 28 févr. 2021,
LysoMod will innovate in the area of personalized medicine for disorders linked to lysosomal dysfunction. This will be achieved by implementing a collaborative staff-exchange program between highly complementary and multidisciplinary academic and non-academic partners with expertise in pharmacology, medicinal chemistry, cell biology, biochemistry, mouse and human genetics, transcriptomics, proteom ...
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8
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TERMINÉ
Releasing the full potential of Instruct to expand and consolidate infrastructure services for integrated structural life science research (INSTRUCT-ULTRA)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
Instruct-Ultra aims to advance the scope and efficiency of implementation of Instruct and consolidate the foundations for long-term sustainability. This will be achieved through specific objectives: expand Instruct membership to new Member States and increase global links; engage new user communities; improve efficiencies in service delivery; improve data capture and management; adjust the scale a ...
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19
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TERMINÉ
Unravelling Fragile 1D Quantum States of Matter Through Ultra-sensitive Imaging (See-1D-Qmatter)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,
In condensed matter physics there are several iconic predictions that have evaded experimental discovery for many decades. Well-known examples include the proposed fractionally-charged quasiparticles in one-dimension, the theorized quantum crystal of electrons, and the elusive Kondo cloud. These sought-after many-body states all share two key aspects underscoring why they are so hard to discover: ...
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1
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TERMINÉ
Transforming the future of agriculture through synthetic photorespiration (FutureAgriculture)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,
For a new green revolution to feed the continually increasing population, agriculture productivity will have to be significantly improved. Photorespiration represents a big challenge in this respect, because it dissipates energy and leads to the futile loss of CO2, thereby limiting plant growth yield. Implementing an efficient metabolic bypass for photorespiration can therefore increase the photos ...
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6
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TERMINÉ
VISUALIZATION OF TOPOLGICAL STATES IN PRISTINE NANOWIRES (TOPO-NW)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,
Topological phases of matter have been at the center of intense scientific research. Over the past decade this has led to the discovery of dozens of topological materials with exotic boundary states. In three dimensional topological phases, scanning tunneling microscopy (STM) has been instrumental in unveiling the unusual properties of these surface states. This success, however, did not encompass ...
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1
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TERMINÉ
Analysis, Design and Experimental Evolution of Novel Carbon Fixation Pathways (NOVCARBFIX)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,
Carbon fixation is a prerequisite for accumulating biomass and storing energy in most of the living world. As such, it supplies our food and dominates land and water usage by humanity. In agriculture, where water and nutrients are abundant, the rate of carbon fixation often limits growth rate. Therefore increasing the rate of carbon fixation is of global importance towards agricultural and energet ...
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1
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TERMINÉ
Nano Voltage Sensors (NVS)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,
To understand how the brain works, tools need to be developed that will allow neuroscientists to investigate how interactions between individual neurons lead to emergent networks. Towards this goal, we will develop targetable voltage sensing nanorods that self-insert into the cell membrane and optically and non-invasively record action potentials at the single particle and nanoscale level, at mult ...
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4
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TERMINÉ
Exploiting light and material interaction (lightMaterInt)
Date du début: 1 déc. 2015, Date de fin: 30 nov. 2020,
The interaction between light and material leads to beautiful visual phenomena that greatly enrich our perception of the world. The ability to measure and model light scattering is central to almost any field of science. However, light transport in rich scenes is a complex process involving a long sequence of scattering events. Computationally modeling, reproducing and acquiring the processes gen ...
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2
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TERMINÉ
Fibre break models for designing novel composite microstructures and applications (FiBreMoD)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2020,
Limiting the climate change-induced temperature increase to less than 2°C will require strong reductions in greenhouse gas emissions. Lightweight materials and fibre-reinforced composites in particular, are a key enabling technology to achieve this goal. Current composite applications are however strongly overdesigned due to a lack of reliable design tools and predictive models for their mechanica ...
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10
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TERMINÉ
Expanding the Topological Frontier in Quantum Matter: from Concepts to Future Applications (TopFront)
Date du début: 1 sept. 2015, Date de fin: 31 août 2020,
Topological phases arise from a fascinating interplay between quantum mechanics and many-body physics. They exhibit an abundance of extraordinary properties, such as protected edge and surface modes, exotic particle statistics, and non-local correlations. These make them not only scientifically stimulating, but also appealing for ground-breaking future applications, such as quantum computing using ...
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2
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TERMINÉ
Systematic exploration of peroxisomal structure and function (PeroxiSystem)
Date du début: 1 sept. 2015, Date de fin: 31 août 2020,
Peroxisomes are ubiquitous and dynamic organelles that house many important pathways of cellular metabolism. This key organelle propagates cellular signals for differentiation, development and metabolism, and thus it is no surprise that a large number of diseases, including metabolic disorders, have been linked to peroxisomal dysfunction. Despite the importance of peroxisomes many fundamental ques ...
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1
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TERMINÉ
Social Chemosignaling as a Factor in Human Behavior in both Health and Disease (SocioSmell)
Date du début: 1 sept. 2015, Date de fin: 31 août 2020,
"We test the working hypothesis that humans are constantly engaging in social chemosignaling, and that this serves as a major yet underappreciated force in shaping human social behavior. A major component of social chemosignaling in macrosmatic mammals is conveying of social status, namely dominance/submissiveness. We start by testing the novel hypothesis that humans similarly share information on ...
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1
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TERMINÉ
Laying the Biological, Computational and Architectural Foundations for Human Cell Lineage Discovery (LineageDiscovery)
Date du début: 1 sept. 2015, Date de fin: 31 août 2020,
Within a decade, advances in single-cell genomics would allow humanity to embark on a coordinated international effort to discover the human cell lineage tree. The goal of LineageDiscovery is to lay the biological, computational and architectural foundations for this envisioned project and demonstrate its feasibility and value.An organismal cell lineage tree is a rooted, labelled binary tree where ...
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1
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TERMINÉ
Sequence and Function Relationships in Long Intervening Noncoding RNAs (lincSAFARI)
Date du début: 1 juin 2015, Date de fin: 31 mai 2020,
It is now clear that many intergenic regions in eukaryotic genomes give rise to a range of processed and regulated transcripts that do not appear to code for functional proteins. A subset of these are long (>200 nt), capped and polyadenylated RNAs transcribed by RNA polymerase II and collectively called long intervening noncoding RNAs or lincRNAs. The recent estimates are that the human genome enc ...
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1
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TERMINÉ
Unraveling changes in cellular gene expression during viral infection (Profile Infection)
Date du début: 1 juin 2015, Date de fin: 31 mai 2020,
The herpesvirus human cytomegalovirus (HCMV) infects the majority of the world's population, leading to severe diseases in millions of newborns and immunocompromised adults annually. During infection, HCMV extensively manipulates cellular gene expression to maintain conditions favorable for efficient viral propagation. Identifying the pathways that the virus relies on or subverts is of great inter ...
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1
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TERMINÉ
Deciphering the role of adult neurogenesis in hippocampal memory codes by optically imaging neuronal activity in freely behaving mice (NeurogenesisCode)
Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,
The hippocampal dentate gyrus (DG) is one of the few areas in the adult mammalian brain that exhibits neurogenesis, the continuous generation of new neurons. Much evidence indicates that adult neurogenesis contributes to hippocampal-dependent cognition, but the nature of this contribution remains elusive. I envisioned that the clearest path towards understanding the function of adult neurogenesis ...
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1
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TERMINÉ
Distributed Biological Algorithms (DBA)
Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,
This project proposes a new application for computational reasoning. More specifically, the purpose of this interdisciplinary project is to demonstrate the usefulness of an algorithmic perspective in studies of complex biological systems. We focus on the domain of collective behavior, and demonstrate the benefits of using techniques from the field of theoretical distributed computing in order to e ...
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2
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TERMINÉ
An integrative approach to uncover the multilevel regulation of 20S proteasome degradation (20SComplexity)
Date du début: 1 avr. 2015, Date de fin: 31 mars 2020,
For many years, the ubiquitin-26S proteasome degradation pathway was considered the primary route for proteasomal degradation. However, it is now becoming clear that proteins can also be targeted for degradation by a ubiquitin-independent mechanism mediated by the core 20S proteasome itself. Although initially believed to be limited to rare exceptions, degradation by the 20S proteasome is now unde ...
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1
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TERMINÉ
Relative representation theory and distributions on reductive groups over local fields (RelRepDist)
Date du début: 1 mars 2015, Date de fin: 29 févr. 2020,
One can view the representation theory of a topological group as non-commutative harmonic analysis on the group. For compact groups this view is justified by the Peter-Weyl theorem. The relative representation theory of a group is harmonic analyses on spaces with transitive group action.I work in relative representation theory of reductive (algebraic) groups over local fields, e.g. the general lin ...
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1
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TERMINÉ
High-Intensity Coherent Nonlinear Optics (HICONO)
Date du début: 1 oct. 2015, Date de fin: 30 sept. 2019,
Optical laser-based technologies are a key technology of the 21st century. Extension of the range of scientific and commercial laser applications requires a constant expansion of the accessible regimes of laser operation. Concepts from nonlinear optics, driven with ultra-fast lasers provide all means to achieve this goal. However, nonlinear optics typically suffer from low efficiencies, e.g. if hi ...
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9
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TERMINÉ
Infrastructure for NMR, EM and X-rays for translational research (iNEXT)
Date du début: 1 sept. 2015, Date de fin: 31 août 2019,
Structural biology provides insight into the molecular architecture of cells up to atomic resolution, revealing the biological mechanisms that are fundamental to life. It is thus key to many innovations in chemistry, biotechnology and medicine such as engineered enzymes, new potent drugs, innovative vaccines and novel biomaterials.iNEXT (infrastructure for NMR, EM and X-rays for Translational rese ...
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