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 EN COURS 

Regulation of DNA interstrand crosslink repair by ubiquitin. (ICLUb)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

The overall objective of this proposal is to understand, on an atomic level, the mechanism of activation and regulation of the Fanconi Anemia (FA) DNA repair pathway. Homozygous mutations in the FA pathway lead to Fanconi Anemia, a devastating childhood genome instability disorder, typified by bone marrow failure and a high predisposition to cancers. The FA pathway is required for the repair of DN ...
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 1

 EN COURS 
T lymphocytes are key cells of the adaptive immune system that protect us against pathogens and malignant cells. T cell activation and differentiation are tightly controlled processes and deregulation can result in lymphomas, autoimmunity and inflammation. Hence, the biochemical events regulating lymphocyte biology have long been a topic of intense research, which has been focussed predominantly o ...
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 1

 EN COURS 
The PATHSENSE (Pathogen Sensing) ETN will bring together an interdisciplinary team of world-leading researchers from Europe to tackle a highly ambitious scientific project, focusing on the molecular mechanisms of sensory perception in bacterial pathogens. PATHSENSE will establish an innovative doctoral training programme that will deliver 13 PhD graduates and high-impact scientific outputs. The re ...
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 14

 EN COURS 

Quantitative and Experimental Biology (QUANTEXBIO)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2020,

... delling and visualization strategies. Perhaps the most critical challenge is to train scientists, able to craft questions that are amenable to interrogation of big data and vice versa. Centred at the University of Dundee’s College of Life Sciences (CLS), the QUANTEXBIO programme will offer a unique menu of doctoral training projects and mobility to a cohort of high-quality ESRs. This inter-discip ...
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 1

 TERMINÉ 

Sensing soil processes for improved crop nitrogen bioavailability (SENSOILS)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Food production is predicated on the application of nitrogen fertilisers, which can contribute significantly to the production of greenhouse gasses and eutrophication of agroecosystems. The use of nitrogen fertilisers must, therefore, be optimised.The recent development of transparent soils in my group gives great scope to unravel the processes involved in the reactive transport of nutrients in so ...
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 3

 TERMINÉ 

iABC Programme (IABC PROGRAMME)

Date du début: 1 août 2015, Date de fin: 31 juil. 2020,

Cystic Fibrosis (CF) is a common fatal inherited disease with a frequency of 1 in 2500 live births, affecting approximately 36,000 (0.737/10,000) people in the EU. Chronic bacterial pulmonary infection leading to an irreversible decline in lung structure and function is the main cause of mortality and morbidity in patients with CF, with more than 95% of deaths due to respiratory failure. Pseudomon ...
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 21

 TERMINÉ 

Real-TIME probing of Ultrafast Phenomena (UPTIME)

Date du début: 1 juil. 2015, Date de fin: 30 juin 2020,

The perception of the world surrounding us depends on how we illuminate and capture it. For example, our direct observation of high-speed phenomena is limited by the speed of the human visual system. A well known method to visualize fast events is to capture them at very high frame rates with high-speed cameras, and then play the movie in slow-motion, enabling us to understand what happens at shor ...
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 1

 TERMINÉ 
Arterial hypertension affects up to 45% of the general population and is responsible for 7.1 million deaths per year worldwide. Although a large therapeutic arsenal exists, blood pressure control is sub-optimal in up to two thirds of patients. Yet, even small increments in blood pressure are associated with increased cardiovascular risk, with 62% of cerebrovascular disease and 49% of ischemic hear ...
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 13

 TERMINÉ 

Targeted small-molecule Stabilisation of Protein-Protein Interactions (TASPPI)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2020,

The goal of the TASPPI European Training Network (ETN) is the establishment of a highly interdisciplinary research and educational training platform for early stage scientists in the Chemical Life Sciences to overcome the inherent boundaries between academia and industry and to increase their employability in both areas. To this end we have teamed up in a consortium comprising 5 partners from indu ...
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 10

 TERMINÉ 

GROW Observatory (GROW)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2019,

The GROW Observatory (GROW) will create a sustainable citizen platform and community to generate, share and utilise information on land, soil and water resource at a resolution hitherto not previously considered. The vision is to underpin smart and sustainable custodianship of land and soil, whilst meeting the demands of food production, and to answer a long-standing challenge for space science, n ...
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 18

 TERMINÉ 

Coordinated Research Infrastructures Building Enduring Life-science services (CORBEL)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

The social and economic challenges of ageing populations and chronic disease can only be met by translation of biomedical discoveries to new, innovative and cost effective treatments. The ESFRI Biological and Medical Research Infrastructures (BMS RI) underpin every step in this process; effectively joining scientific capabilities and shared services will transform the understanding of biological m ...
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 39

 TERMINÉ 

Unravelling PIM kinase signal integration in the T cell response (PIM PROTEOMICS)

Date du début: 1 juil. 2017, Date de fin: 30 juin 2019,

Understanding how T cells integrate alternative signal combinations to determine immune response strength and functionality is of critical importance for rational design of immunomodulatory therapies. The PIM kinase family have been identified as important regulators of cell division, survival and protein synthesis independent of, but in parallel to the key signalling molecule mTOR. I propose to u ...
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 1

 TERMINÉ 
Neuropathic pain (NP) is common (population prevalence of 7-8%) and will present a rising health burden in the future. NP results in significant morbidity, reduces quality of life and has a major deleterious impact on health in aging. The reason why some subjects develop neuropathic pain and others do not following the same injury is not known. The exact nature of risk factors for NP and their int ...
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 14

 TERMINÉ 

POVERTY, INCOME, AND EMPLOYMENT NEWS (PIE News)

Date du début: 1 juil. 2016, Date de fin: 30 juin 2019,

The overall ambition of the PIE News project is to foster the emergence of commonfare as an alternative economic model to fight poverty, a condition affecting some 25% of the European population. Commonfare is a new collaborative form of welfare provision based on equitable governance and grassroots democracy. It entails the involvement of diverse stakeholders to facilitate the bottom-up arousal o ...
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 9

 TERMINÉ 

Multidisciplinary Approaches to Translational Research In Conduct Syndromes (MATRICS)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,

Conduct Disorder (CD) is the key paediatric disorder characterized by severe aggression. It is heterogeneous, and our understanding of the neurobiology to subtype aggression is limited. MATRICS is a multidisciplinary consortium of academic partners and SMEs that focuses on the subtyping of aggression both within CD and of the broader cross-disorder trait of aggression. MATRICS will test the hypoth ...
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 21

 TERMINÉ 

DIabetes REsearCh on patient sTratification (DIRECT)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2019,

The overarching aims of the DIRECT consortium, consisting of 20 leading academic groups in diabetes and 5 EFPIA companies, are to identify biomarkers that address current bottlenecks in diabetes drug development and to develop a stratified medicines approach to treatment of type 2 diabetes with either existing or novel therapies.There is heterogeneity in who develops diabetes, the rate at which th ...
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 27

 TERMINÉ 
"The innate immune system provides an immediate response to infection and injury. It relies on the detection of pathogen-associated molecular patterns (PAMPs), molecular hallmarks of infection which are shared amongst different pathogens but are absent from healthy host cells. The detection of intracellular DNA as PAMP has emerged a key event in the innate immune response to DNA viruses, retrovir ...
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 1

 TERMINÉ 
MR-guided Focused Ultrasound Surgery (MRgFUS) combines high intensity focused ultrasound for thermal ablation of diseased tissue with MR imaging to visualise the tumour and surrounding anatomy and to provide MR thermal feedback.However, MRgFUS treatment of the liver and other abdominal organs present tremendous technological challenges, including motion due to breathing and shielding of the target ...
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 11

 TERMINÉ 
Digital technology has radically changed the way people work in industry, finance, services, media and commerce and has urged necessary corresponding changes in educational systems. However there is a lack of progress in the education arena. Hence, recent studies show that high percentages of college graduates can't find work, the dropout rate is high and new generations are moving back into their ...
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 12

 TERMINÉ 
"The EC H2020 funded "Global BioImaging Project" enables Euro-BioImaging, the research infrastructure for access to biological and medical imaging technologies on the ESFRI roadmap, to work together with its international counterparts - the Australian Microscopy and Microanalysis Research Facility (AMMRF), the National Imaging Facility (Australia) and India-BioImaging - on concrete and sustainable ...
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 8

 TERMINÉ 

Strategic Dialogue on Sustainable Raw Materials for Europe (STRADE)

Date du début: 1 déc. 2015, Date de fin: 30 nov. 2018,

STRADE addresses the long-term security and sustainability of the European raw material supply from European and non-European countries. It will develop dialogue-based, innovative policy recommendations for a European strategy on future raw-material supplies.STRADE will initially concentrate on the industry perspective. Based on an analysis of the European mineral raw-material mining sector’s comp ...
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 7

 TERMINÉ 
Concept and aim: 20 million fans attend top division football games each week and many more watch on TV. Our social innovation is to attract people to lifestyle change through the personal connection and loyalty to the club they support. Our aim is to use this social innovation to change physical activity and sedentary behaviour, specially targeting low-SES groups, and men as well as women. EuroFI ...
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 13

 TERMINÉ 

Multi-Use in European Seas (MUSES)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2018,

The Multi-Use in European Seas (MUSES) project will review existing planning and consenting processes against international quality standards for MSP and compliance with EU Directives used to facilitate marine and coastal development in the EU marine area to ensure that they are robust, efficient and facilitate sustainable multi use of marine resources. The project will build knowledge of the appr ...
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 10

 TERMINÉ 
Aggression is a basic physiological trait with important roles throughout evolution, both in defence and predation. When expressed in humans in the wrong context, aggression leads to maladjustment, social impairment and crime. Despite this, knowledge about aggression aetiology is limited and current treatment strategies are insufficient. Contingent to a subdivision into impulsive and instrumental ...
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 27

 TERMINÉ 
Climate change threatens the stability of infrastructure slopes, which form a large proportion of the European transport network. Slope failures due to increasing intense rainfall have already resulted in significant socio-economic loss across the Europe. Slope revegetation is identified as a more environmentally friendly and aesthetically pleasing stabilisation technique, when compared to other h ...
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 1

 TERMINÉ 

Harnessing Cavitation for Therapy (TheraCav)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

Focused Ultrasound Surgery (FUS) is rapidly emerging as a technique setting the gold-standard for the treatment of a wide range of diseases, including cancer. Current practise relies on the conversion of acoustic energy to thermal, for localised and minimally-invasive ablation with non-ionising radiation. Cavitation (the formation, and subsequent pressure driven dynamics, of bubbles) is a common o ...
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 2

 TERMINÉ 

ZNHIT6: a new SUMO E3 ligase regulating RNA metabolism (SUMO-ZNHIT6-snoRNPs)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2018,

It is widely accepted that eukaryotic cells contain large populations of small nucleolar RNA-protein complexes (snoRNPs), which mediate the modification of rRNA nucleotides and facilitate cleavage of rRNA precursors. Thus, they may control general protein translation by regulating the level and function of ribosomes. It is currently thought that understanding the process of snoRNP biogenesis will ...
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 1

 TERMINÉ 
The Anchor E3s project proposes to establish, for the first time, an efficient protocol for the discovery and characterisation of accessible binding sites at any patch of a protein surface, regardless of its involvement in biological function. One of the motivation of the research is to develop a general approach to discover new “anchor” ligands that can enable improved plug-and-play proteolysis t ...
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 1

 TERMINÉ 
This proposal addresses the call topic ‘Advancing bioinformatics to meet biomedical and clinical needs’ (PHC-32-2014), with the focus on the standardization, dissemination and meta-analysis of cell migration data. Cell migration is the fundamental process in medically highly relevant topics, including morphogenesis, immune function, wound healing, and cancer metastasis, and the study of cell migra ...
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 10

 TERMINÉ 

Kansainvälisen työssäoppimisverkoston yhteistyömuotojen kehittäminen

Date du début: 1 juin 2016, Date de fin: 31 mai 2018,

PROJECT BACKGROUND:North Karelia municipal education and training consortium development work is based on 2016-2019 development strategy. International operations are specifically aimed at promoting the effectiveness of developing student's skills for working life, and contribute that the student will find his/her position in the labor market.By enabling staff´s and students mobility international ...
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 27

 TERMINÉ 
This proposal is centred on the development and application of chemical tools to probe molecular recognition of multiprotein complexes. Although much effort has been devoted to targeting protein-protein interactions using small molecules, these have focused to date on individual gene products or truncated domains, which however do not reflect the physiological organization and activity of many fun ...
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 1

 TERMINÉ 

Skill Matching Assistance and Reporting Tool

Date du début: 1 avr. 2016, Date de fin: 31 mars 2018,

... sations and a technical partner will bring in the expertise to run a project that considers many perspectives and needs. The chair of Business, Human Resource Education and Evaluation Research of the University of Paderborn is highly experienced in the field of career orientation, the development of competency models and evaluation in general. Professor Jindal-Snape from the University of Dundee i ...
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 5

 TERMINÉ 
The research field of proteomics proceeds rapidly thanks to recent technological advances of instrumentation, methodology, and software development. Next Generation Proteomics (NGP) refers to the integration of these three areas to provide a systematic approach for measuring proteome dynamics in both time and space during various cellular responses. In this proposal, I will analyze pre-ribosomal p ...
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 1

 TERMINÉ 

Chromosome self-clearing completes sister chromatid separation (SELFCC)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2018,

"In this research program, we propose the new concept that sister chromatid separation in mitosis is completed as a result of the dynamic intrinsic structural changes of chromosomes, i.e. through cycles of regional chromosome stretching and recoiling, which we call the self-clearing mechanism of chromosomes. By developing several novel methods, we will establish this new concept and demonstrate th ...
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 2

 TERMINÉ 
We are currently seeing a deceleration of renewable energy growth in Europe. This is partly attributed to the challenges for financing renewable energy projects. Reduced access to conventional financing options over the past few years has triggered innovative financing schemes to emerge, with crowdfunding attracting a lot of attention.CrowdFundRES recognises the vast potential of crowdfunding for ...
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 16

 TERMINÉ 

The molecular basis of NleB-mediated bacterial virulence (BATTLE)

Date du début: 4 janv. 2016, Date de fin: 3 janv. 2018,

Bacterial pathogens have evolved distinct ways of colonizing host cells and promote infection. Many human intestinal bacterial pathogens such as Salmonella, Shigella and enteropathogenic/ enterohemorrhagic Escherichia coli utilize type III secretion systems to deliver virulence effector proteins into the host to promote colonization and interfere with antimicrobial host response. Among the type II ...
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 1

 TERMINÉ 

REwiring the nucleus TowaRds plant ImmuNity (RETRaIN)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

Plant pathogenic microbes cause significant economic damage to global food crop production systems. Pathogens are specialised microbes that manipulate the host defense circuitry to suppress immunity and promote virulence. Interestingly, many of the processes that determine immunity or susceptible interactions, take place in the host nucleus. With the identification of vast repertoires of (nuclear) ...
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 1

 TERMINÉ 

European Lead Factory (EUC²LID)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

The European Lead Factory concept proposed by the EUC2LID Consortium relates to the discovery of novel small molecule candidates to serve as starting points for subsequent optimization to either drug candidates or high-quality pharmacological tools for the experimental validation of targets. The concept intends to bridge academic and applied research interests. The European Lead Factory will provi ...
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 34

 TERMINÉ 

Euro-BioImaging Preparatory Phase II - Project (EuBI PPII)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2017,

Euro-BioImaging (EuBI) is the pan-European research infrastructure project for imaging technologies in biological and medical sciences and has been on the ESFRI Roadmap since 2008. In close match with the scope and objectives of the INFRADEV2 call, Preparatory Phase II (PPII) funding will enable EuBI:• to finalize the submission and approval procedure of its ERIC statutes with the EC and bring the ...
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 21

 TERMINÉ 

Parasite glycobiology and anti-parasitic strategies (GLYCOPAR)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2017,

"Protozoan parasites and helminths are the cause of some of the most devastating diseases worldwide and a major effort is needed to be able to control or eliminate these diseases. Glycoconjugates are abundant and ubiquitous on the surface of many parasites and they are frequently involved in their survival strategies by forming a protective barrier against host defences. A common feature of the pa ...
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 13