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 TERMINÉ 

Combatting Bacterial Resistance in Europe - Molecules against Gram Negative Infections (COMBACTE-MAGNET)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2021,

Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte ...
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 44

 TERMINÉ 

An Integrated European ‘Flagship’ Program Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century (EU-ToxRisk)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2021,

The vision of EU-ToxRisk is to drive a paradigm shift in toxicology towards an animal-free, mechanism-based integrated approach to chemical safety assessment. The project will unite all relevant disciplines and stakeholders to establish: i) pragmatic, solid read-across procedures incorporating mechanistic and toxicokinetic knowledge; and ii) ab initio hazard and risk assessment strategies of chemi ...
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 43

 TERMINÉ 

Adaptive Bio-electronics for Chronic Cardiorespiratory Disease (CResPace)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

This consortium will pioneer disruptive technology for bio-electronic medicine to provide much needed therapies for cardiorespiratory and functional neurological disease. The technology implements small neural networks known as central pattern generators (CPG) to deliver fit-and-forget bio-electronic implants that respond to physiological feedback in real time, are safer, simpler, non-invasive, an ...
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 8

 TERMINÉ 

Clinical development and proof of principle testing of new regenerative VEGF-D therapy for cost-effective treatment of refractory anginaA phase II randomized, double-blinded, placebo-controlled study (ReGenHeart)

Date du début: 1 janv. 2017, Date de fin: 30 juin 2021,

Chronic angina pectoris is a debilitating chronic disease, a subgroup of these patients suffers from refractory angina which unfortunately can’t be controlled by medical therapy (angioplasty or surgery). Refractory angina is a substantial burden on the individual and healthcare system, in Europe there are 100,000 new cases per year, annual mortality of these patients is relatively low (
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 10

 TERMINÉ 

Towards enduring mouse resources and services advancing research into human health and disease (INFRAFRONTIER2020)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

The INFRAFRONTIER RI integrates European Mouse Clinics and the European Mouse Mutant Archive with the common goal to ensure access to mouse models for basic research of human health and disease, and to translate this knowledge into therapeutic approaches for the benefit of the European society. The expanded INFRAFRONTIER2020 network, coordinated by the INFRAFRONTIER GmbH, includes 3 SMEs and is st ...
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 33

 TERMINÉ 

Ubiquitous Pharmacogenomics (U-PGx): Making actionable pharmacogenomic data and effective treatment optimization accessible to every European citizen (U-PGx)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Pharmacogenomics is the study of genetic variability affecting an individual’s response to a drug. Its use allows personalized medicine and reduction in ‘trial and error’ prescribing leading to more efficacious, safer and cost-effective drug therapy. The U-PGx consortium will investigate a pre-emptive genotyping approach (that is: multiple pharmacogenomic variants are collected prospectively and ...
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 16

 TERMINÉ 

Hybrid optical and optoacoustic endoscope for esophageal tracking. (ESOTRAC)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

More than 450.000 people are diagnosed with esophageal cancer (EC) each-year worldwide and approximately 400.000 die from the disease. Esophageal cancer is the eighth most commonly diagnosed cancer, but it is the sixth leading cause of cancer-related death, with incidence rates steeply rising. Risk factors, including gastroesophageal reflux disease and Barrett’s esophagus, may diagnostically impli ...
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 9

 TERMINÉ 

Effect of ALlopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome (ALBINO)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Neonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of death or long-term disability in infants born at term in the western world, affecting about 1-4 per 1.000 life births and consequently about 5-20.000 infants per year in Europe.Hypothermic treatment became the only established therapy to improve outcome after perinatal hypoxic-ischemic insults. Despite hypothermia and neonatal inte ...
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 18

 TERMINÉ 

European Network on Anti-Cancer Immuno-Therapy Improvement by modification of CAR and TCR Interactions and Nanoscale Geometry (EN_ACTI2NG)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

The EN-ACTI2NG program (European Network on Anti-Cancer Immuno-Therapy Improvement by modification of CAR and TCR Interactions and Nanoscale Geometry) emanates from the recent clinical evidence that T cells expressing engineered tumor-specific immune receptors can eradicate certain tumors that do not respond to conventional treatment. To obtain T cells with reactivity to a wider array of tumors an ...
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 11

 TERMINÉ 

From microbial interactions to new-concept biopesticides and biofertilizers (INTERFUTURE)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2020,

The Directive 2009/128/EC sets rules in EU for the sustainable use of pesticides to reduce the risks and impacts of pesticide use on people's health and the environment. Among the listed actions there is the promotion of low pesticide-input management including non-chemical methods. In parallel several chemical active ingredients have been banned because of toxicity concerns. The result is that gr ...
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 11

 TERMINÉ 

Analytical and Characterisation Excellence in nanomaterial risk assessment: A tiered approach (ACEnano)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2020,

An increasing number of nanomaterials (NMs) are entering the market in every day products spanning from health care and leisure to electronics, cosmetics and foodstuff. Nanotechnology is a truly enabling technology, with unlimited potential for innovation. However, the novelty in properties and forms of NMs makes the development of a well-founded and robust legislative framework to ensure safe dev ...
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 27

 TERMINÉ 

Applied Public-Private Research enabling OsteoArthritis Clinical Headway (APPROACH)

Date du début: 1 juin 2015, Date de fin: 30 nov. 2020,

The problem: finding the right patient for the right treatmentDespite a large and growing disease burden in osteoarthritis (OA), many pharmaceutical companies have de-emphasized or even abandoned OA drug development due to perceived hurdles. Crucial in this is the lack of appropriate outcome measures that can robustly identify patient benefit from a specific therapy. The lack of specific and sensi ...
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 25

 TERMINÉ 

Biowaste derived volatile fatty acid platform for biopolymers, bioactive compounds and chemical building blocks (VOLATILE)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2020,

VOLATILE aims in the development of an innovative Volatile Fatty Acids Platform for the bioconversion of municipal solid bio-waste fraction and sludgy biowaste from other industries. The platform will be integrated in anaerobic digestion. The volatile fatty acids will be recovered continuously using sophisticated membrane technology and will be provided as feedstock / carbon source for value added ...
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 21

 TERMINÉ 

Technology Enabled Adolescent Mental Health (TEAM)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2020,

There is no health without mental health. 27% of our population are young, and mental health disorders are our leading cause of disability. 50% of mental disorders emerge by 14 yrs, 75% by 24 yrs and, untreated, triple odds of having a mental health disorder in later life. TEAM’s will build a network of expertise and train a new generation of researchers to deliver more effective, affordable and f ...
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 9

 TERMINÉ 

Low energy ELEctron driven chemistry for the advantage of emerging NAno-fabrication methods (ELENA)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2020,

Chemistry is fundamental to nanotechnology, as chemistry can prepare specifically tailored molecules to serve, in a bottom-up approach, as the building blocks for the fabrication of functional and structured nano-materials. Nanotechnology is the technology of the 21st century with applications from electronics to biotechnology and medicine. The next decade will thus be characterized by an increasi ...
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 14

 TERMINÉ 

An e-infrastructure for software, training and consultancy in simulation and modelling (E-CAM)

Date du début: 1 oct. 2015, Date de fin: 30 sept. 2020,

E-CAM will create, develop and sustain a European infrastructure for computational science applied to simulation and modelling of materials and of biological processes of industrial and societal importance. Building on the already significant network of 15 CECAM centres across Europe and the PRACE initiative, it will create a distributed, sustainable centre for simulation and modelling at and acro ...
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 18

 TERMINÉ 

The artificial pancreas in children aged 1 to 7 years with type 1 diabetes (KidsAP)

Date du début: 1 janv. 2017, Date de fin: 30 juin 2020,

TYPE 1 DIABETES is one of the most COMMON CHRONIC diseases in children with a RAPID increase in number of cases particularly in young children. Type 1 diabetes is associated with LIFE-LONG dependency on insulin administration. POOR glucose control leads to diabetes COMPLICATIONS, e.g. eye, heart, kidney disease, including BRAIN changes in young children. Episodes of VERY LOW glucose levels may be ...
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 14

 TERMINÉ 

RELapses prevENTion in chronic autoimmune disease: common mechanisms and co-morbidities (RELENT)

Date du début: 1 nov. 2015, Date de fin: 30 avr. 2020,

RELENT is multidisciplinary group of scientists and clinical investigators whose goal is to develop individualized treatment for chronic autoimmune diseases, such as rheumatoid arthritis and vasculitis, that cause considerable mortality and morbidity, both from uncontrolled disease and treatment associated co-morbidities, like infection and malignancy. This requires the need to stratify patients b ...
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 14

 TERMINÉ 

Social Innovation in Marginalised Rural Areas (SIMRA)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2020,

SIMRA seeks to advance understanding of social innovation (SI) and innovative governance in agriculture, forestry and rural development (RD), and how to boost them, particularly in marginalised rural areas across Europe, with a focus on the Mediterranean region (including non-EU) where there is limited evidence of outcomes and supporting conditions. These objectives will be achieved by: 1. Develop ...
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 26

 TERMINÉ 

Safe Food and Feed through an Integrated ToolBox for Mycotoxin Management (MyToolBox)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

MyToolBox mobilises a multi-actor partnership (academia, farmers, technology SMEs, food industry and policy stakeholders) to develop novel interventions aimed at achieving a 20-90% reduction in crop losses due to fungal and mycotoxin contamination. MyToolBox will not only pursue a field-to-fork approach but will also consider safe use options of contaminated batches, such as the efficient producti ...
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 23

 TERMINÉ 

Innovative Management of Genetic Resources (IMAGE)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

This aim of IMAGE is to enhance the use of genetic collections and to upgrade animal gene bank management. IMAGE will better exploit DNA information and develop methodologies, biotechnologies, and bioinformatics for rationalising animal genetic resources. It will demonstrate the benefits brought by gene banks to the development of sustainable livestock systems by: enhancing the usefulness of genet ...
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 28

 TERMINÉ 

TRANSPORT OF SOFT MATTER AT THE NANOSCALE (NANOTRANS)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

We propose a Multi-Partner ITN-ETN network on Transport of Soft Matter at the Nanoscale. The scientific topic, which is the focus of the proposal, is an emerging field of science and technology. Challenges such as design of environmentally friendly engineering materials or understanding the principles of biological organization crucially depend on fundamental understanding of transport of fluids a ...
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 10

 TERMINÉ 

Calcium-Sensing Receptor (CaSR): Therapeutics for Non-Communicable Diseases (CaSR Biomedicine)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

The calcium sensing receptor (CaSR) is a class C Gprotein-coupled receptor that plays a pivotal role in systemic calcium metabolism by regulating parathyroid hormone secretion and urinary Ca excretion. Abnormal CaSR function is implicated in calciotropic disorders, and in non-calciotropic disorders such as Alzheimer’s disease (AD), cardiovascular disease (CVD), diabetes (DM), sarcopenia and cancer ...
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 13

 TERMINÉ 

Translating neuroimaging findings from research into clinical practice (PSYSCAN)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2020,

Abstract 9Neuroimaging (NI) has enormous potential to improve the clinical care of patients with psychiatric disorders, but has yet to deliver. The PSYSCAN project will address this issue directly by developing a NI-based tool that will help clinicians resolve key clinical issues in the management of patients with psychotic disorders. Clinicians will use the tool to assess patients with a standard ...
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 24

 TERMINÉ 

Development and application of Novel, Integrated Tools for monitoring and managing Catchments (INTCATCH)

Date du début: 1 juin 2016, Date de fin: 31 janv. 2020,

INTCATCH will instigate a paradigm shift in the monitoring and management of surface water quality that is fit for global waters in the period 2020-2050. INTCATCH will do this by developing efficient, user-friendly water monitoring strategies and systems based on innovative technologies that will provide real time data for important parameters, moving towards SMART Rivers. The business model will ...
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 23

 TERMINÉ 

Ophthalmic OCT on a Chip (OCTCHIP)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

Silicon photonics is expected to leverage-off many of the advances made in CMOS electronics. International R&D efforts in this field have so far been mainly focused on the silicon-on-insulator (SOI) photonic integrated circuit (PIC) technology platform because it is predestined for datacom, high-performance computing and telecom applications. However, SOI based integrated optical waveguides cannot ...
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 7

 TERMINÉ 

Smart Sensor Technologies and Training for Radiation Enhanced Applications andMeasurements (STREAM)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

STREAM is a 4-year multi-site training network that aims at career development of Early Stage Researchers (ESRs) on scientific design, construction manufacturing and of advanced radiation instrumentation. STREAM targets the development of innovative radiation-hard, smart CMOS sensor technologies for scientific and industrial applications. The platform technology developed within the project will b ...
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 11

 TERMINÉ 

Role of European Mobility and its Impacts in Narratives, Debates and EU Reforms (REMINDER)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2019,

The overarching goal of the project is to understand the economic, social, institutional and policy factors that have shaped the impacts of free movement and public debates about it. It aims to help European policymakers develop policy responses that inspire public trust, ensure the fairness and sustainability of free movement, and maintain inclusive policies that reduce inequalities across the co ...
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 14

 TERMINÉ 

A Large-Scale Systems Approach to Flood Risk Assessment and Management (SYSTEM-RISK)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

Flood risk systems are characterised by physical and socio-economic processes acting at different space-time scales, by non-stationary and non-linear behaviour, and by a significant degree of interdependence between processes. This may lead to surprising developments and unanticipated side effects of risk reduction measures. A novel systems approach is needed that captures this dynamics and accoun ...
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 11

 TERMINÉ 

Autologous Stem Cell Seeded Tissue Engineered Trachea (TETRA)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

CLINICAL PROBLEM AND UNMET NEEDThere are 11,827 patients with severe structural airway disease in Europe. Even with the current standard of care, when hospitalised this group of patients has a 22% risk of dying. Patients are currently subjected to repeated surgical interventions (stent insertion) which have a high failure rate. Other therapeutic strategies under development include synthetic trac ...
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 14

 TERMINÉ 

MRI and Ultrasound Robotic Assisted Biopsy (MURAB)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

The MURAB project has the ambition to revolutionise the way cancer screening and muscle diseases are researched for patients and has the potential to save lives by early detection and treatment.The project intends to create a new paradigm in which, the precision of great medical imaging modalities like MRI and Ultrasound are combined with the precision of robotics in order to target the right plac ...
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 8

 TERMINÉ 

Algebraic Representations in Computer-Aided Design for complEx Shapes (ARCADES)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

ARCADES aims at disrupting the traditional paradigm in Computer-Aided Design (CAD) by exploiting cutting-edge research in mathematics and algorithm design. Geometry is now a critical tool in a large number of key applications; somewhat surprisingly, however, several approaches of the CAD industry are outdated, and 3D geometry processing is becoming increasingly the weak link. This is alarming in s ...
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 9

 TERMINÉ 

Advanced TeChnologies and PlatfoRm fOr Smarter ASsisted LivING (ACROSSING)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

Smart Home (SH) provides a promising approach to assisted living for the ageing population. Yet it still remains a challenge to develop and deploy such solutions in a large scale due to the lack of an easy-to-use technology infrastructure and application exemplars. This problem arises from the nature of the SH field: multidisciplinary, diverse in its applications, and with multiple stakeholders. W ...
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 10

 TERMINÉ 

INTERFACES

Date du début: 1 juin 2016, Date de fin: 30 nov. 2019,

Interfaces is an international, interdisciplinary project where a range of new audiences engage with new music. It unites nine diverse partners from 8 European countries plus several other European and international associate partners, with extensive and varied experience in performing, multi-media, new media, acoustic and electroacoustic research, community action and education. This rich experti ...
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 9

 TERMINÉ 

Privacy and Usabiliy (Privacy.Us)

Date du début: 1 déc. 2015, Date de fin: 30 nov. 2019,

With the rapid accumulation and processing of personal data by numerous organizations, it is of paramount importance to protect people from adverse uses of their data, while allowing them to enjoy the benefits the use of these data can possibly provide. This is the question of protecting citizens’ privacy, while enabling them to make informed decisions regarding their actions with privacy implicat ...
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 10

 TERMINÉ 

Changing Energy Efficiency Technology Adoption in Households (CHEETAH)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2019,

Modelling analyses typically suggest that policies accelerating the adoption of energy-efficient technologies (EETs) by overcoming barriers to energy efficiency in the residential sector provide benefits for individual households, the energy system and for society as a whole. Yet, implicit discount rates, employed to reflect households’ decision criteria and response to policy, are disputed in pol ...
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 6

 TERMINÉ 

GROW Observatory (GROW)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2019,

The GROW Observatory (GROW) will create a sustainable citizen platform and community to generate, share and utilise information on land, soil and water resource at a resolution hitherto not previously considered. The vision is to underpin smart and sustainable custodianship of land and soil, whilst meeting the demands of food production, and to answer a long-standing challenge for space science, n ...
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 18

 TERMINÉ 

In the eye of the observer: Visual processing at the heart of the retina (switchBoard)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2019,

All visual information is broadcasted by an intra-retinal pathway formed by a group of neurons called bipolar cells. They collect photoreceptor signals in the outer retina and relay the signals to the inner retinal neurons. This transfer of visual information is far from passive: Each of the at least 10 bipolar cell types transforms the photoreceptor signals in a unique and highly specific way. As ...
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 11

 TERMINÉ 

A training network for the chemical site-selective modification of proteins: Preparation of the next-generation of therapeutic chemically-defined protein conjugates (ProteinConjugates)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2019,

ProteinConjugates is an inter- and multi-disciplinary network for the education of talented young scientists who will learn how to rationally design and construct the next generation of chemically-defined and innovative protein drug-conjugates for the targeted treatment of serious conditions such as cancer or rheumatoid arthritis. A complementary interaction between academy and pharmaceutical indu ...
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 8

 TERMINÉ 

High sensitivity, portable photonic device for pervasive water quality analysis (WaterSpy)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2019,

Pervasive and on-line water quality monitoring data is critical for detecting environmental pollution. However, it’s not easy to gather such data, at least not for all contaminants. Currently, water utilities rely heavily on frequent sampling and laboratory analysis in order to acquire this information.For this situation to be improved, portable and high-performance devices for pervasive water qua ...
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 9