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Plus de 40 projets européens trouvés

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 TERMINÉ 

Clinical proof of concept through a randomised phase II study: a combination of immunotherapy and stereotactic ablative radiotherapy as a curative treatment for limited metastatic lung cancer (IMMUNOSABR)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2022,

IMMUNOSABR is geared towards opening up a new paradigm in treating metastatic cancer by obtaining clinical proof of concept for a novel bi-modal curative treatment strategy. High precision stereotactic ablative radiotherapy (SABR) is combined with immunotherapy to form a powerful synergistic anti-tumour strategy. The approach relies on the direct cytotoxic effect of SABR, the abscopal effect of ra ...
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 17

 TERMINÉ 

Combatting Bacterial Resistance in Europe - Molecules against Gram Negative Infections (COMBACTE-MAGNET)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2021,

Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte ...
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 44

 TERMINÉ 

Collective effects and optomechanics in ultra-cold matter (ColOpt)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

The network “Collective effects and optomechanics in ultra-cold matter” (ColOpt) will train early-stage researchers (ESR) in fundamental science and applications in the areas of cold atom and quantum physics, optical technologies and complexity science to promote European competiveness in emergent quantum technologies. It consists of nine academic nodes and three companies from six European countr ...
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 13

 TERMINÉ 

Children’s Liver Tumour European Research Network (ChiLTERN)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Liver cancer in the paediatric population is rare with an incidence approximately 1-1.5 per million population. The commonest tumour seen in the childhood population is hepatoblastoma (HB), usually seen in young children and infants. Much rarer (about 10% of paediatric liver cancers) is hepatocellular carcinoma (HCC), usually seen in the teenage population and sometimes associated with underlying ...
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 21

 TERMINÉ 

Effect of ALlopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome (ALBINO)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Neonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of death or long-term disability in infants born at term in the western world, affecting about 1-4 per 1.000 life births and consequently about 5-20.000 infants per year in Europe.Hypothermic treatment became the only established therapy to improve outcome after perinatal hypoxic-ischemic insults. Despite hypothermia and neonatal inte ...
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 18

 TERMINÉ 

Educational Network in Ocular Drug Delivery and Therapeutics (OcuTher)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2020,

Ocular drug development has transformed from niche area to a major field in drug development in which many companies, including European big pharma has entered recently. Ocular drug development is a unique field in terms of drug targets and end-points of activity, local drug administration routes, tissue barriers and pharmacokinetics, drug delivery and formulation challenges and local toxicity iss ...
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 9

 TERMINÉ 

A Clinical Decision Support system based on Quantitative multimodal brain MRI for personalized treatment in neurological and psychiatric disorders (CDS-QUAMRI)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

A large number of neurological and psychiatric disorders lack objective criteria for primary diagnoses, early differential diagnosis with regard to subtypes in treatment response and disease progression or effective therapy monitoring resulting in a tremendous negative socio-economic impact. Scientific studies based on advanced MRI methods indicate that related patients show specific subtle change ...
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 7

 TERMINÉ 

Reconsidering European Contributions to Global Justice (GLOBUS)

Date du début: 1 juin 2016, Date de fin: 31 mai 2020,

GLOBUS critically assesses the EU’s impact on justice in a global system characterised by uncertainty, risk and ambiguity. GLOBUS defines a new research agenda for the study of the EU’s global role. This agenda directs attention to underlying political and structural challenges to global justice that are prior to the distributive problem, as well as to the fact that what is just is contested both ...
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 8

 TERMINÉ 

Conservative iron chelation as a disease-modifying strategy in Parkinson’s disease: a multicentric, parallel-group, placebo-controlled, randomized clinical trial of deferiprone (FAIR-PARK-II)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

Parkinson’s disease (PD) is a major, chronic, non-communicable disease and the 2nd most frequent neurodegenerative disorder worldwide. Excess iron is primarily detected in the substantia nigra pars compacta, where dopaminergic neurons are exposed to high levels of oxidative stress produced by mitochondrial disorders and dopamine metabolism. Our previous preclinical, translational and pilot clinica ...
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 17

 TERMINÉ 

New geomodels to explore deeper for High-Technology critical raw materials in Alkaline rocks and Carbonatites (HiTech AlkCarb)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2020,

Five of the 20 raw materials identified by the European Commission as critical are commonly found in association with alkaline rocks and carbonatites (heavy and light rare earth elements, niobium, fluorspar, and phosphate). Other elements increasingly important for ‘hi-tech’ applications, and found in these rocks include hafnium (Hf), tantalum (Ta), scandium (Sc) and zirconium (Zr). In fact, there ...
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 12

 TERMINÉ 

Myopia: Fundamental understanding needed (MyFUN)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

The proposed ETN “Myopia: fundamental understanding needed” (MyFUN) provides an international, interdisciplinary platform to train young scientists at the interface of physics and biology, to study unresolved questions about the visual control of eye growth. It has been extensively documented that the growth of the eye is controlled by closed-loop visual feedback, using retinal image defocus as an ...
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 7

 TERMINÉ 

Probing safety of nano-objects by defining immune responses of environmental organisms (PANDORA)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

PANDORA (Probing safety of nano-objects by defining immune responses of environmental organisms) shall assess the global impact of engineered nanoparticles (NP) on the immune responses of representative organisms covering all evolutionary stages and hierarchical levels from plants to invertebrates and vertebrates. Immunity is a major determinant of the survival and fitness of all living organisms, ...
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 10

 TERMINÉ 

In the eye of the observer: Visual processing at the heart of the retina (switchBoard)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2019,

All visual information is broadcasted by an intra-retinal pathway formed by a group of neurons called bipolar cells. They collect photoreceptor signals in the outer retina and relay the signals to the inner retinal neurons. This transfer of visual information is far from passive: Each of the at least 10 bipolar cell types transforms the photoreceptor signals in a unique and highly specific way. As ...
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 11

 TERMINÉ 

ALK Activation as a target of TRAanslational Science (ALKATRAS): Break free from cancer (ALKATRAS)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

This ETN is embedded into an established international research programme; The European Research Initiative on Anaplastic Lymphoma Kinase (ALK)-related malignancies (ERIA; www.erialcl.net) is an existing and functional network of 13 partners, which will cosset and nurture a cohort of early stage researchers to become confident, competent, independent and well-connected European scientists with exc ...
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 13

 TERMINÉ 

Studying, Measuring and Altering Consciousness through information theory in the electrical brain (LUMINOUS)

Date du début: 1 mars 2016, Date de fin: 31 août 2019,

What is consciousness? Can it be measured? While humankind has struggled with these questions for millennia, our project will focus on more modest but nonetheless ambitious and related goals. Inspired by recent developments in neuroscience and the potential role of fundamental concepts such as information integration and algorithmic complexity, we will study, model, quantify, and alter observable ...
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 8

 TERMINÉ 

Diabetes Reversing Implants with enhanced Viability and long-term Efficacy (DRIVE)

Date du début: 1 juin 2015, Date de fin: 31 mai 2019,

Diabetes mellitus is a chronic disease characterised by high blood glucose due to inadequate insulin production and/or insulin resistance which affects 382 million people worldwide. Pancreatic islet transplantation is an extremely promising cure for insulin-sensitive diabetes mellitus (ISDM), but side effects of lifelong systemic immunosuppressive therapy, short supply of donor islets and their po ...
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 14

 TERMINÉ 

Exploring the combined role of genetic and non-genetic factors for developing Age-Related Macular Degeneration: A systems level analysis of disease subgroups, risk factors, and pathways (EYE-RISK)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2019,

Age-related macular degeneration (AMD) is the world’s most important age-related blinding disorder. The current proposal utilises epidemiological data describing clinical phenotype, molecular genetics, lifestyle, nutrition, and in-depth retinal imaging derived from existing longitudinal European epidemiological cohorts and biobanks to provide three major insights needed for long-lasting prevention ...
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 13

 TERMINÉ 

Integrated Activities for the High Energy Astrophysics Domain (AHEAD)

Date du début: 1 sept. 2015, Date de fin: 28 févr. 2019,

We propose a set of integrated Activities in the High Energy Astrophysics Domain (AHEAD) in response to the INFRAIA-2014-2015 call Research Infrastructures for High EnergyAstrophysics.The overall objective of AHEAD is to integrate national efforts in high-energy Astrophysics and to promote the domain at the European level, to keep its community at the cutting edge of science and technology in this ...
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 26

 TERMINÉ 

TWINNING for a Comprehensive Clinical Centre for the Diagnosis and Treatment of Parkinson's Disease (CENTRE-PD)

Date du début: 1 mars 2016, Date de fin: 28 févr. 2019,

...he gap between basic science and clinical application is now a crucial challenge. CENTRE-PD aims at TWINNING the Universities of Oxford and Tübingen, two worldwide leading centres for PD, with the University of Luxembourg (UL) to establish a comprehensive clinical PD centre in Luxembourg. CENTRE-PD will build human and institutional capacity for an excellent centre for diagnosis and treatment of P ...
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 3

 TERMINÉ 

Cognitive Interaction in Motion (CogIMon)

Date du début: 1 févr. 2015, Date de fin: 31 janv. 2019,

Compliant control in humans is exploited in a variety of sophisticated skills. These include solitary actions such as soft catching, sliding, pushing large objects as well as joint actions performed in teams such as mainpulation of large scale objects or mutual adaptation through phyiscal coupling for learning, in walking or in execution of joint tasks. We refer to this advanced ability of organiz ...
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 10

 TERMINÉ 

DIabetes REsearCh on patient sTratification (DIRECT)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2019,

The overarching aims of the DIRECT consortium, consisting of 20 leading academic groups in diabetes and 5 EFPIA companies, are to identify biomarkers that address current bottlenecks in diabetes drug development and to develop a stratified medicines approach to treatment of type 2 diabetes with either existing or novel therapies.There is heterogeneity in who develops diabetes, the rate at which th ...
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 27

 TERMINÉ 

MANAGING THE EFFECTS OF MULTIPLE STRESSORS ON AQUATIC ECOSYSTEMS UNDER WATER SCARCITY (GLOBAQUA)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

Water and water-related services are major components of the human wellbeing, and as such are major factors of socio-economic development in Europe; yet freshwater systems are under threat by a variety of stressors (organic and inorganic pollution, geomorphological alterations, land cover change, water abstraction, invasive species and pathogens. Some stressors, such as water scarcity, can be a st ...
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 27

 TERMINÉ 

The Neurobiology of Decision-Making in Eating - Innovative Tools (NUDGE-IT)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,

Nudge-it engages internationally leading experts in the neurobiology of motivational behaviour, the neuroscience of reward pathways, the neuroendocrinology of homeostatic regulation of appetite, experimental psychology, functional brain imaging, behavioural economics, and computational modelling. They will work together to develop new tools and approaches that can provide the evidence needed to in ...
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 10

 TERMINÉ 

REgeneration of inner ear hair cells with GAmma-secretase INhibitors to regain hearing in patients with sensorineural hearing loss (REGAIN)

Date du début: 1 mai 2015, Date de fin: 31 oct. 2018,

Hearing loss is a chronic non-communicable disease disabling over 328 million adults, and 32 million children worldwide. Sensorineural hearing loss due to loss of auditory hair cells was long thought to be irreversible. However, recent animal studies have demonstrated that pharmacological inhibition of cell signalling via Notch receptors using gamma-secretase inhibitors (GSIs) can regenerate hair ...
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 7

 TERMINÉ 

Tools for Teaching Quantitative Thinking

Date du début: 1 sept. 2015, Date de fin: 31 août 2018,

Quantitative thinking is at the heart of modern societies. Skills and programming competences related to quantitative thinking increase a student's employability and allow an enlightened citizen to make informed decisions. Every day we are bombarded and challenged by quantitative information: How long will a journey be delayed due to traffic? What are the chances of a change in weather conditio ...
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 12

 TERMINÉ 

Cancer Vaccine development for Hepatocellular Carcinoma (HepaVac)

Date du début: 1 sept. 2013, Date de fin: 31 août 2018,

"Hepatocellular carcinoma (HCC) is the most common primary liver cancer and accounts for about 6% of all new cancer cases worldwide. Given the lack of available effective treatments, the overall prognosis for HCC patients is poor, with a dismal 5-year survival of 5-6%. The main goal of this proposal is to develop a therapeutic cancer vaccine aiming at improving clinical outcome in early-stage HCC ...
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 10

 TERMINÉ 

EUDAT2020

Date du début: 1 mars 2015, Date de fin: 28 févr. 2018,

EUDAT2020 brings together a unique consortium of e-infrastructure providers, research infrastructure operators, and researchers from a wide range of scientific disciplines under several of the ESFRI themes, working together to address the new data challenge. In most research communities, there is a growing awareness that the “rising tide of data” will require new approaches to data management and ...
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 36

 TERMINÉ 

Systems Biology to Identify Molecular Targets for Vascular Disease Treatment (SYSVASC)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2018,

Asymptomatic vascular damage accumulates for years before patients are identified and subjected to therapeutic measures. The limited knowledge on early vascular disease pathophysiology is reflected in the lack of therapeutic options. SysVasc aims to overcome this limitation by mounting a comprehensive systems medicine approach to elucidate pathological mechanisms, which will yield molecular target ...
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 19

 TERMINÉ 

European Training in Neural Regulation of Intestinal Function (NeuroGut)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2018,

"Neurogastroenterology is a new and emerging medical/scientific subspecialty that currently has no formal training opportunities in medicine and related disciplines. It includes basic science aspects (neurophysiology, neurobiology, neuropsychology, psychophysiology) and clinical aspects (gastroenterology, neurology, internal medicine, surgery, psychology, psychosomatic medicine) of the neural cont ...
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 12

 TERMINÉ 

Human stem cell applications for the treatment of hearing loss (OTOSTEM)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,

Hearing impairment is the most frequent human sensory deficit and is mainly caused by the irreversible loss of neurosensory cells in the cochlea. The lack of human otic cell models represents a significant roadblock that has hampered the development of drug-based or cell-based therapies for the treatment of hearing loss. In a collaborative effort under this proposal we wish to devise approaches to ...
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 10

 TERMINÉ 

The biogenesis of tail-anchored membrane proteins: knowledge and exploitation (TAMPTING)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,

Even in the simplest cells, the integration of proteins into a biological membrane is a complex process that is frequently coupled to ribosomal protein synthesis, and requires the coordinated actions of several additional cellular machines. The de novo recapitulation of such a complex process is well beyond the scope of our current technical abilities. Indeed, the techniques that are used to creat ...
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 8

 TERMINÉ 

Taking imaging into the therapeutic domain: Self-regulation of brain systems for mental disorders (BRAINTRAIN)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,

Our proposal is based on the idea that real-time functional neuroimaging can be used to train patients to regulate their own brain activity via neurofeedback training and thus modulate the brain networks of mental disorder, restore function, improve symptoms and promote resilience. We have brought together the core groups that have been instrumental in the development of methods for real-time func ...
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 12

 TERMINÉ 

Developing and Testing a novel, low-cost, effective HOOKworm VACcine to Control Human Hookworm Infection in endemic countries (HOOKVAC)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

Approximately 600-700 million people are infected by hookworm, primarily in sub-Saharan Africa, Southeast Asia, and Latin America. Hookworm infection ranks number one in terms of Years Lost from Disability from a neglected infectious disease, and among the top 3 in terms of lost Disability-Adjusted Life Years. HOOKVAC will be developing the first and only vaccine for human hookworm infection. A ...
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 9

 TERMINÉ 

Integrated European –omics research project for diagnosis and therapy in rare neuromuscular and neurodegenerative diseases (Neuromics)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,

Neurodegenerative (ND) and neuromuscular (NM) disease is one of the most frequent classes of rare diseases, affecting life and mobility of 500,000 patients in Europe and millions of their caregivers, family members and employers. This NEUROMICS project brings together the leading research groups in Europe, five highly innovative SMEs and relevant oversea experts using the most sophisticated Omics ...
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 20

 TERMINÉ 

DRIVING RE-INVESTMENT IN R&D AND RESPONSIBLE ANTIBIOTIC USE (DRIVE-AB)

Date du début: 1 oct. 2014, Date de fin: 30 sept. 2017,

Antimicrobial resistance (AMR) is widespread. Its global human and economic burden is tremendous and increasing annually. Yet today only a few pharmaceutical companies retain active antibacterial drug discovery programmes. While the elaboration of antibiotics with novel mechanisms of action is scientifically complex, the chief challenge is diminishing incentives. Pre-market regulatory requirements ...
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 27

 TERMINÉ 

Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in EUrope (EU-CERT-ICD)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

An estimated 500.000 sudden cardiac deaths (SCD) occur each year in the European Union. Patients at risk for SCD may benefit from prophylactic treatment with an implantable cardioverter-defibrillator (ICD). ICD implantations have dramatically increased in recent years leading to multi-billion Euros of costs with significant regional disparities across Europe. Information on risks, benefits and cos ...
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 27

 TERMINÉ 

Concealed Objects Stand-Off Real-Time Imaging for Security (CONSORTIS)

Date du début: 1 janv. 2014, Date de fin: 28 févr. 2017,

"The project will develop a demonstrator for stand-off real-time concealed object detection for future implementations of high throughput security screening for European mass-transit markets and infrastructure security. The technological approach will incorporate a multi-frequency passive submillimetre-wave video camera, coupled with an active 340 GHz 3D imaging radar system. Both systems will be ...
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 12

 TERMINÉ 

Glioma Actively Personalized Vaccine Consortium (GAPVAC)

Date du début: 1 nov. 2012, Date de fin: 31 janv. 2017,

"Glioblastoma (GBM) is a rare (2-3 incidences in 100,000) and fatal disease. Each year, approximately 13,000 new cases of GBM are diagnosed in Europe. The 5-year survival rate of this highly aggressive tumor entity under conventional therapy is less than 6%. Currently available therapeutic options neglect the individuality of each patients’ disease and only temporarily influence tumor progression ...
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 13

 TERMINÉ 

Industrial Academic Initial Training Network towards focused treatment of age-related motor symptoms (MOVING BEYOND)

Date du début: 1 oct. 2012, Date de fin: 31 janv. 2017,

Gait and postural control impairments, and falls are ubiquitous among the elderly, and lead to enormous personal, occupational and health care burden. Especially patients with PD are severely affected by the progressive deterioration of these gait and postural control mechanisms. Elucidating mechanisms of age- and disease-related motor control impairments and devising focussed treatment strategies ...
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 9

 TERMINÉ 

Hybrid Architecture for quantum Information using Rydberg ensembles and Superconductors (HAIRS)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2017,

We propose to solve the long-standing problem of coupling quantum states in atoms to solid-state quantum devices. The realization of such a quantum interface represents a major breakthrough for information science, as it enables the development of a powerful hybrid architecture, where long-lived states of atoms store quantum information that can be processed rapidly using superconducting quantum c ...
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 6