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 EN COURS 
Animals harbor specialized bacterial communities in their guts, typically referred to as gut microbiomes. Despite the importance of gut microbiomes for host health, surprisingly little is known about their evolution. There is evidence that the complexity of the mammalian gut microbiome has emerged through the diversification of a few founder lineages. However, how lineages have diversified into di ...
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 1

 EN COURS 

Optimizing a deployable high efficacy malaria vaccine (OptiMalVax)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

A highly effective malaria vaccine against Plasmodium falciparum should help prevent half a million deaths from malaria each year. New vaccine technologies and antigen discovery approaches now make accelerated design and development of a highly effective multi-antigen multi-stage subunit vaccine feasible. Leading malariologists, vaccine researchers and product developers will here collaborate in ...
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 17

 EN COURS 
Cell fusion is critical for fertilization and development, for instance underlying muscle or bone formation. Cell fusion may also play important roles in regeneration and cancer. A conceptual understanding is emerging that cell fusion requires cell-cell communication, polarization of the cells towards each other, and assembly of a fusion machinery, in which an actin-based structure promotes membra ...
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 1

 EN COURS 

Central integration of metabolic and hedonic cues in metabolic health (INTEGRATE)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,

During evolution the brain has selected glucose as a main source of metabolic energy. This has imposed homeostatic and behavioral constraints. First, the glycemic levels must be maintained at a minimum of ~5 mM to ensure constant energy supply to the brain. Second, a high reward value has to be attributed to glucose-containing foods to increase the motivation to obtain them. These homeostatic and ...
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 1

 EN COURS 
ARTIVISM aims at exploring new artistic forms of political expression under difficult, precarious and/or oppressive conditions. It asks how social actors create belonging and multiple forms of resistance when they use art in activism or activism in art. What kind of alliances do these two forms of social practices generate in super-diverse places, in times of crisis and in precarious situations? T ...
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 1

 EN COURS 
This project aims to study what key institutions and policies are best suited to reduce incentives for engaging in appropriation and armed conflict. For achieving and sustaining peace it is crucial to get the incentives right of all main actors in society. While subproject 1 focuses on short-run policies to stop the fighting by drying out the funding of rebel groups and hence move from war to peac ...
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 1

 EN COURS 

Novel interactions and species’ responses to climate change (NICH)

Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,

A great ecological challenges is predicting the responses of species, communities and ecosystems to global climate change. Progress will hinge on our ability to predict how responses are shaped by evolution and species interactions, and especially by entirely novel interactions among species whose ranges don't yet overlap. To tackle this goal, I will combine cutting-edge experiments and process-ba ...
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 1

 EN COURS 

Innovative Nanowire DEvicE Design (INDEED)

Date du début: 1 févr. 2017, Date de fin: 31 janv. 2021,

Nanowires (NWs) exhibit unique properties that make them potential building blocks for a variety of next generation NanoElectronics devices. Recent advances have shown that NWs with predefined properties can be grown, offering a new paradigm enabling functional device prototypes including: biosensors, solar cells, transistors, quantum light sources and lasers. The critical mass of scientific knowl ...
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 12

 EN COURS 
The prioritisation and deployment of knowledge within an economy remains a key success factor for long-term economic development, increased productivity and socio-economic sustainability. The achievement of knowledge-driven growth is particularly challenging for emerging market economies that are still seeking to catch up to the frontier knowledge economies. The project seeks to understand the cau ...
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 2

 EN COURS 

Laser Lightning Rod (LLR)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Controlling lightning is a long time dream of mankind. The goal of the present project is to investigate and develop a new type of lightning protection based on the use of upward lightning discharges initiated through a high repetition rate multi terawatt laser. The feasibility of the novel technique and the project’s prospect of success are based on recent research providing new insights into the ...
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 9

 EN COURS 
All chemicals whether they are drugs, cosmetics, agrochemicals or others need to be tested for their safety to man and the environment. The use of whole animal studies for the prediction of adverse effects in man, is problematic due to species dependent effects, high costs and a large burden to animals in terms of numbers and suffering. While there have been major improvements in human in vitro a ...
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 14

 EN COURS 
Many HIV vaccine concepts and several efficacy trials have been conducted in the prophylactic and therapeutic fields with limited success. There is an urgent need to develop better vaccines and tools predictive of immunogenicity and of correlates of protection at early stage of vaccine development to mitigate the risks of failure. To address these complex and challenging scientific issues, the Eur ...
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 43

 EN COURS 
A novel concept for a photo-electro-catalytic (PEC) cell able to directly convert water and CO2 into fuels and chemicals (CO2 reduction) and oxygen (water oxidation) using exclusively solar energy will be designed, built, validated, and optimized. The cell will be constructed from cheap multifunction photo-electrodes able to transform sun irradiation into an electrochemical potential difference (e ...
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 15

 EN COURS 
The ENIGMA network will train a new generation of young researchers in the development of innovative sensors, field survey techniques and inverse modelling approaches. This will enhance our ability to understand and monitor dynamic subsurface processes that are key to the protection and sustainable use of water resources. ENIGMA focuses mainly on critical zone observation, but the anticipated tech ...
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 11

 EN COURS 

OMT - Optomechanical Technologies (OMT)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2020,

The proposed project is built on the successful training and research experience of the leading European research groups working in the field of cavity optomechanics. Our ENT unites a total of 14 leading groups in the field, of which two are major industrial players that utilize MEMS and NEMS - Bosch and IBM. The main goal of the project is to exploit optomechanical interactions in views of novel ...
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 14

 EN COURS 

Professional cross-priming for ovary and prostate cancer (PROCROP)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Immune responses are initiated by antigen presentation mediated by dendritic cells (DC). There is a minority subset of DC highly specialised in starting up cytotoxic T lymphocytes able to kill tumor cells. PROCROP aims to develop in three pilot clinical trials a suitable individualized cancer vaccine technology for castration resistant prostate cancer and metastatic cancer of the ovary that would ...
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 8

 TERMINÉ 

Ontogenetic transcriptome evolution in tetrapods (OntoTransEvol)

Date du début: 1 févr. 2015, Date de fin: 31 janv. 2020,

A central goal in evolutionary biology is to understand the molecular changes responsible for phenotypic differences between species, in particular those that have arisen among mammals. Phenotypic evolution is thought to be largely founded on developmental gene regulatory changes, which determine species-specific tissue morphologies and thus lay the foundation for their typical physiological prope ...
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 2

 TERMINÉ 

Advanced European Network of E-infrastructuresfor Astronomy with the SKA (AENEAS)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2019,

The objective of the AENEAS project is to develop a concept and design for a distributed, federated European Science Data Centre (ESDC) to support the astronomical community in achieving the scientific goals of the Square Kilometre Array (SKA). The scientific potential of the SKA radio telescope is unprecedented and represents one of the highest priorities for the international scientific communit ...
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 31

 TERMINÉ 

Non-Noble Metal Catalysis - NoNoMeCat (NoNoMeCat)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

Transition metal catalysts are formidable tools towards greener chemistry, allowing for low-waste, energy-efficient, and selective reactions. However, the noble metals (Ru, Os, Rh, Ir, Pd, Pt) that are currently most common in homogeneous catalysts suffer from high toxicity and environmental impact in addition to their scarcity and ensuing high cost. First-row metals (Mn, Fe, Co, Ni, Cu) are emerg ...
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 9

 TERMINÉ 
Considerable challenges remain today regarding Europe´s transition towards a decarbonised energy system that meets the economic and social needs of its citizens. Rebound effects, that is, a full or partial cancelling-out of efficiency gains over time through increased overall energy use, highlight the centrality of consumption in multi-scalar decarbonisation efforts, urgently requiring attention f ...
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 10

 TERMINÉ 
TERRE aims to develop novel geo-technologies to address the competitiveness challenge of the European construction industry in a low carbon agenda. It will be delivered through an inter-sectoral and intra-European coordinated PhD programme focused on carbon-efficient design of geotechnical infrastructure. Industry and Research in the construction sector have been investing significantly in recent ...
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 14

 TERMINÉ 

Constructing an Alliance for Value-driven Cybersecurity (CANVAS)

Date du début: 1 sept. 2016, Date de fin: 31 août 2019,

The growing complexity of the digital ecosystem in combination with increasing global risks entail the danger that enforcing cybersecurity may bypass other fundamental values like equality, fairness or privacy, whereas downplaying cybersecurity would undermine citizens’ trust and confidence in the digital infrastructure. Technology developers as well as legal and philosophical scholars and empiric ...
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 12

 TERMINÉ 

Brain barriers training (BtRAIN)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

The brain barriers function to protect the central nervous system (CNS) from neurotoxic compounds. By the same traits they unfortunately block delivery of drugs to the CNS thus hindering proper diagnosis and effective treatment of neurological disorders including Alzheimer’s disease and multiple sclerosis. The unusual complexity of the brain barriers has severely hampered progress in the market of ...
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 11

 TERMINÉ 

Evolution of olfactory circuits (EVONEURO)

Date du début: 1 juin 2014, Date de fin: 31 mai 2019,

"Nervous systems have undergone remarkable diversification in their structure and function as animals have adapted to distinct ecological niches. What are the genetic mechanisms underlying neural circuit evolution? The project addresses this fundamental question in the Drosophila olfactory system, a superior ""evo-neuro"" model for several reasons: (i) as in mammals, the Drosophila olfactory syste ...
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 1

 TERMINÉ 

European Circular Energy-Frontier Collider Study (EuroCirCol)

Date du début: 1 juin 2015, Date de fin: 31 mai 2019,

The award of the 2013 Nobel Prize for Physics acknowledged the leading role of Europe in particle physics, which has a global community of over 10,000 scientists. To reinforce its pole position throughout the 21st century, Europe must be ready to propose an ambitious post-LHC accelerator project by 2018/19. This is one of the main recommendations of the updated European Strategy for Particle Physi ...
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 17

 TERMINÉ 

The endodermis - unraveling the function of an ancient barrier (ENDOFUN)

Date du début: 1 juin 2014, Date de fin: 31 mai 2019,

"In addition to maintaining homeostasis within their cells, multicellular organisms also need to control their inner, extracellular spaces between cells. In order to do so, epithelia have developed, bearing ring-like paracellular barriers, with specialised membrane surfaces facing either the environment or the inner space of the organism. In animals, such polarised epithelia use specialised protei ...
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 1

 TERMINÉ 
Terrestrial and marine ecosystems provide essential services to human societies. Anthropogenic pressures, however, cause serious threat to ecosystems, leading to habitat degradation, increased risk of collapse and loss of ecosystem services. Knowledge-based conservation, management and restoration policies are needed to improve ecosystem benefits in face of increasing pressures. ECOPOTENTIAL makes ...
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 47

 TERMINÉ 

Strengthening Animal Production and Health through the Immune Response (SAPHIR)

Date du début: 1 mars 2015, Date de fin: 28 févr. 2019,

SAPHIR aims to develop vaccine strategies effective against endemic pathogens responsible for high economic losses in livestock in order to strengthen the profitability of food animal systems, improve animal welfare and reduce xenobiotic usage in farming with a One Health perspective. SAPHIR will bring novel vaccine strategies to the market i) at short term, with several promising vaccines brought ...
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 22

 TERMINÉ 
The project’s key assumption is that Rousseau and Ferguson offer a distinctive “partisan-republican” perspective. More strongly than fellow-republicans like Montesquieu, Hume and Smith, they focus on commercial society’s corrupting effects, concluding that the only remedy is a recovery of traditional civic virtues.Objectives1. The project fills a major lacuna in Enlightenment historiography: the s ...
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 1

 TERMINÉ 

Genetic/epigenetic basis of ethnic differences in cancer predisposition (ECAP)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

"Integration of large scale genetic and epigenetic analysis needs to be coupled with well defined biological hypotheses that can be experimentally tested. This project is aimed at developing a novel integrated approach to understand genetic and epigenetic predisposition to cancer with skin as model system.The Caucasian (West European) and Asian (East Asian) populations differ substantially in thei ...
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 1

 TERMINÉ 
In the 90s, two landmark observations brought to a paradigm shift about the role of astrocytes in brain function: 1) astrocytes respond to signals coming from other cells with transient Ca2+ elevations; 2) Ca2+ transients in astrocytes trigger release of neuroactive and vasoactive agents. Since then, many modulatory astrocytic actions and mechanisms were described, forming a complex - partly contr ...
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 1

 TERMINÉ 
The main objective of the proposal is to contribute to a better harmonisation and synchronisation of priority-setting-, funding- evaluation and life-cycle management of Research Infrastructures (RI through the exchange of best practices among the main stakeholders in member states, associated countries and at European level. The regional dimension will explicitly be taken into account by integrati ...
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 14

 TERMINÉ 
Emerging personalised medicine initiatives have the perspective to cut healthcare costs and improve the overall health of the population. Taking into account the individual’s molecular characteristics complemented by environmental and lifestyle factors, will allow to develop more precise and improved disease prevention and treatment programs compared to conventional methods. As an example of pote ...
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 3

 TERMINÉ 
Reproduction and diet are the two main factors that affect aging in a wide range of animal species, including humans. Recent studies suggest that the link between these factors and aging is controlled by genes related to fat metabolism and nutrient sensing, but the exact role of these genes in lifespan and late-life health remains to be elucidated. In addition, most of the known 'aging' genes were ...
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 1

 TERMINÉ 
The TBVAC2020 proposal builds on the highly successful and long-standing collaborations in subsequent EC-FP5-, FP6- and FP7-funded TB vaccine and biomarker projects, but also brings in a large number of new key partners from excellent laboratories from Europe, USA, Asia, Africa and Australia, many of which are global leaders in the TB field. This was initiated by launching an open call for Express ...
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 49

 TERMINÉ 

Building an IoT OPen innovation Ecosystem for connected smart objects (bIoTope)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2018,

The Internet of Things (IoT) brings opportunities for creating new services and products, reducing costs for societies, increasing the service level for the citizens in a number of areas, and changing how services are sold and consumed. Despite these opportunities, current information system architectures create obstacles that must be addressed for leveraging the full potential of IoT. One of the ...
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 23

 TERMINÉ 

European Clearing House for Open Robotics Development Plus Plus (ECHORD Plus Plus)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

Description ECHORD++ will create new opportunities for European robotics researchers to work directly with SME/start-ups and new users/customers to create innovative products. ECHORD++ will continue ECHORD’s two pillars, “experiments” and “structured dialogue”, taking advantage of experience and investment in the infrastructure. In addition, ...
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 68

 TERMINÉ 

Role of the stroma-derived ‘alarmin’ IL-33 in anti-viral immunity (STRAVIR)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2018,

There is increasing awareness that the recently identified cytokine IL-33 is playing a key role in multiple types of infections and pathologies. It has been recently demonstrated that IL-33 is crucial for mounting an efficient immune response against viral infections as it strongly enhances T cell responses with lack of IL-33 leading to failure in virus control. IL-33 production by stromal cells i ...
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 1

 TERMINÉ 

ODYSSEUS-MONNET NETWORK ON IMMIGRATION AND ASYLUM

Date du début: 1 sept. 2015, Date de fin: 31 août 2018,

The main rationale of the project is to forge, throughout the Member States, a European community of researchers and professors in the field of EU immigration and asylum who, despite the existing important cooperation and personal links, do not benefit from a consistent enough framework at EU level. Establishing “the place to be” virtually or physically sometimes per year to meet, exchange and net ...
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 22

 TERMINÉ 

MASTER GEOGRAPHICAL MODELLING CAMPUS+e

Date du début: 1 sept. 2015, Date de fin: 31 août 2018,

The increased complexity of urban and regional systems and the rise of massive digital and open data require that future students master an enlarged portfolio of geographical modelling tools and can relate them with other types of models in order to innovate in research and in planning practice. Likewise, trainers of geographical models and researchers across Europe also need to cross-fertilize th ...
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 9