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 EN COURS 
In times of austerity, the politics of the welfare state involve tough choices and even trade-offs: whose risks should benefit from social solidarity in a context of shrinking resources? Should the welfare state prioritize the needs of the elderly or those of the young? Those of people in the workforce or outside of the workforce? Of natives or of immigrants? How countries answer these key questio ...
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 1

 EN COURS 

Multisystem Cell Therapy for Improvement of Urinary Continence (MUSIC)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

"Stress Urinary Incontinence (SUI) is a disease affecting over 200 million people worldwide. It represents a condition with a prevalence of 20-50% in women, thereby creating an immense socio-economic burden. The currently available treatment strategies entail various complications and offer only short-term relief to the patients. Tissue engineering using autologous cells offers a feasible alternat ...
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 5

 EN COURS 

Fostering responsive mental health systems in the Syrian refugee crisis (STRENGTHS)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

STRENGTHS aims to provide effective community-based health care implementation strategies to scale-up the delivery and uptake of effective mental health interventions in different country contexts. The current refugee crisis across Europe and the Middle East effects both individual refugees’ psychological well-being, as they face extreme stressors in their flight from their home country, but also ...
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 15

 EN COURS 
Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte ...
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 44

 EN COURS 

Adaptive Bio-electronics for Chronic Cardiorespiratory Disease (CResPace)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

This consortium will pioneer disruptive technology for bio-electronic medicine to provide much needed therapies for cardiorespiratory and functional neurological disease. The technology implements small neural networks known as central pattern generators (CPG) to deliver fit-and-forget bio-electronic implants that respond to physiological feedback in real time, are safer, simpler, non-invasive, an ...
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 8

 EN COURS 

Wiring up the SomatoSensory Cortex (InterWiring)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2021,

Understanding how the mammalian brain network acquires its ability during development to process information and interact with the environment is one of the fundamental challenges in modern biology.The brain originates from a sheet of neural progenitors during embryogenesis but rapidly develops into distinct functional areas such as primary sensory and the highly associative cortices. Although all ...
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 1

 EN COURS 

Bacterial cooperation at the individual cell level (BactInd)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

All levels of life entail cooperation and conflict. Genes cooperate to build up a functional genome, which can yet be undermined by selfish genetic elements. Humans and animals cooperate to build up societies, which can yet be subverted by cheats. There is a long-standing interest among biologists to comprehend the tug-of-war between cooperation and conflict. Recently, research on bacteria was suc ...
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 1

 EN COURS 
Neural stem/progenitor cells (NSPCs) continue to generate new neurons throughout life in distinct regions of the mammalian brain. Adult neurogenesis has been implicated in brain function and altered neurogenesis has been associated with a number of neuropsychiatric diseases such as depression and cognitive ageing. A key feature of somatic stem cell division is the ability to divide asymmetrically ...
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 1

 EN COURS 
Spatial and temporal changes in the underlying biochemistry of cancer control disease progression and response/resistance to treatment. Developing methods to detect changes in oncogenic signaling at an early stage is vital to further our understanding of cancer, and will advance the next generation of anti-cancer therapies. Nanomedicine is the medical application of nanotechnology to diagnose or t ...
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 1

 EN COURS 
Studying host-pathogen interactions by focusing on the interaction of a single pathogen with the host has defined our understanding of these events and the insights gained form the basis for the therapeutic and vaccination strategies we use today. However, people become infected with multiple pathogens throughout their lifetime, at times even simultaneously. Still, it is largely unknown how the im ...
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 1

 EN COURS 
While many neurons live for decades, the proteins that determine neural function have half-lives of hours to weeks. On the one hand, this allows for plastic changes during development and learning. On the other hand, this poses the question of how stable neural function can be achieved and maintained at all. Several neurological diseases, such as epilepsy or migraine, have been linked to uncontrol ...
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 1

 EN COURS 
Substantial advances in cosmology over the past decades have firmly established the standard model of cosmology. However, the physical nature of the early Universe and dark energy (or inflationary cosmology) remains poorly understood. To resolve these issues, a large number of galaxy surveys are planned to measure millions of galaxies in the sky, promising precision measurements of galaxy cluster ...
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 1

 EN COURS 

Mesoscale Brain Dynamics: Computing with Neuronal Pathways (BRAINCOMPATH)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2021,

Brain computations rely on proper signal flow through the complex network of connected brain regions. Despite a wealth of anatomical and functional data – from microscopic to macroscopic scale – we still poorly understand the principles of how signal flow is routed through neuronal networks to generate appropriate behavior. Brain dynamics on the 'mesoscopic' scale, the intermediate level where loc ...
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 1

 EN COURS 

Collective effects and optomechanics in ultra-cold matter (ColOpt)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

The network “Collective effects and optomechanics in ultra-cold matter” (ColOpt) will train early-stage researchers (ESR) in fundamental science and applications in the areas of cold atom and quantum physics, optical technologies and complexity science to promote European competiveness in emergent quantum technologies. It consists of nine academic nodes and three companies from six European countr ...
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 13

 EN COURS 

Readiness of ICOS for Necessities of integrated Global Observations (RINGO)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

The proposed project “Readiness of ICOS for Necessities of integrated Global Observations” (RINGO) aims to further development of ICOS RI and ICOS ERIC and foster its sustainability. The challenges are to further develop the readiness of ICOS RI along five principal objectives: 1. Scientific readiness. To support the further consolidation of the observational networks and enhance their quality. Th ...
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 26

 EN COURS 
Spinal cord injury is a severe and devastating neurological disorder that leaves patients with permanent paralysis of the body. No treatment is available today to regenerate interrupted nerve fibers and repair the damaged spinal cord. The incidence of spinal cord injury is about newly injured 10’000 people per year in the EU, and due to an almost normal life expectancy more than 200’000 patients a ...
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 12

 EN COURS 
The npSCOPE project aims at developing a new integrated instrument (the nanoparticle-scope) optimised for providing a complete physico-chemical characterisation of nanoparticles both in their pristine form or embedded in complex matrices such as biological tissues. Using sophisticated correlative data processing methodologies and algorithms based on statistical methods in conjunction with appropri ...
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 9

 EN COURS 
Many HIV vaccine concepts and several efficacy trials have been conducted in the prophylactic and therapeutic fields with limited success. There is an urgent need to develop better vaccines and tools predictive of immunogenicity and of correlates of protection at early stage of vaccine development to mitigate the risks of failure. To address these complex and challenging scientific issues, the Eur ...
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 43

 EN COURS 

Micro/Nano Robotics for Single Cancer Cells (MNR4SCell)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Cancer is considered as the second leading cause of death worldwide. It is important to develop methodologies that improve understanding of the disease condition and progression. Over the past few years, single cell biology has been performed using micro/nano robotics for exploration of the nanomechanical and electrophysiological properties of cells. However, most of the research so far has been e ...
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 5

 EN COURS 
A novel concept for a photo-electro-catalytic (PEC) cell able to directly convert water and CO2 into fuels and chemicals (CO2 reduction) and oxygen (water oxidation) using exclusively solar energy will be designed, built, validated, and optimized. The cell will be constructed from cheap multifunction photo-electrodes able to transform sun irradiation into an electrochemical potential difference (e ...
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 15

 EN COURS 

Synthetic bacterial lipid rafts to optimize industrial bioprocesses (Rafts4Biotech)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Genetic tractability of bacterial cells allows generating synthetic microbial chassis platforms (SMCPs) with remarkable biotechnological applications but their functionality currently faces important off-genome limitations due to deficient protein-protein interactions, unfavorable protein stoichiometry or generation of toxic intermediates that ultimately compromise the industrial production proces ...
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 13

 EN COURS 

Open transPREcision COMPuting (OPRECOMP)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Guaranteed numerical precision of each elementary step in a complex computation has been the mainstay of traditional computing systems for many years. This era, fueled by Moore's law and the constant exponential improvement in computing efficiency, is at its twilight: from tiny nodes of the Internet-of-Things, to large HPC computing centers, sub-picoJoule/operation energy efficiency is essential f ...
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 10

 EN COURS 
Neonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of death or long-term disability in infants born at term in the western world, affecting about 1-4 per 1.000 life births and consequently about 5-20.000 infants per year in Europe.Hypothermic treatment became the only established therapy to improve outcome after perinatal hypoxic-ischemic insults. Despite hypothermia and neonatal inte ...
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 18

 EN COURS 

Lubricant impregnated slippery surfaces (LubISS)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

LubISS, Lubricant Impregnated Slippery Surfaces, is the first European Training Network with the main objectives of designing, characterizing, and modelling low adhesive easy-to-clean surfaces for anti-icing and anti-fouling. In a coordinated effort among 9 world-class academic institutions and industrial partners from 6 European countries (Finland, France, Germany, Great Britain, Netherlands, Swi ...
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 9

 EN COURS 
In PlantHUB will capture the academic, industrial and regulatory expertise from 5 world-class universities, 1 public research organisation, 1 governmental organization, 8 enterprises including 5 SMEs to train 10 ESRs in skills and competencies necessary to apply responsible research and innovation (RRI) in the area of plant breeding and production. We wish to address the demand of RRI leadership i ...
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 10

 EN COURS 
CRESCENDO brings together seven Earth System Modelling (ESM) groups with three Integrated Assessment Modelling teams, as well as experts in ESM evaluation, ESM projection and feedback analysis, climate impacts and science communication to address the following goals; (i) improve the process-realism and simulation-quality of European ESMs in order to increase the reliability of future Earth system ...
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 25

 EN COURS 

Function and malfunction of the prion protein (PRION2020)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2020,

Transmissible spongiform encephalopathies (TSE) are caused by the ordered aggregation of PrPC into prions consisting of PrPSc. Similar pathogenetic principles operate in Alzheimer’s and Parkin-son’s disease, and a growing list of further diseases whose prevalence is steadily rising. Familial TSE are invariably associated with PrPC mutations, and the dearth of genetic modifiers has hampered our und ...
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 1

 EN COURS 

Fishfriendly Innovative Technologies for Hydropower (FIThydro)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2020,

FIThydro addresses the decision support in commissioning and operating hydropower plants (HPP) by use of existing and innovative technologies. It concentrates on mitigation measures and strategies to develop cost-efficient environmental solutions and on strategies to avoid individual fish damage and enhancing population developments. Therefore HPPS all over Europe are involved as test sites. The f ...
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 26

 EN COURS 
Industries are in need of highly skilled academically trained experts and powerful sets of tools enabling the design, control & prediction of optimized & efficient production process of future high-value products such as chiral pharmaceuticals. The CORE Network will in parallel train 15 ESRs and develop tools, approaches and methods within the area of Continuous Resolution (CORE), the process to o ...
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 8

 EN COURS 
A large number of neurological and psychiatric disorders lack objective criteria for primary diagnoses, early differential diagnosis with regard to subtypes in treatment response and disease progression or effective therapy monitoring resulting in a tremendous negative socio-economic impact. Scientific studies based on advanced MRI methods indicate that related patients show specific subtle change ...
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 7

 EN COURS 
Global trends in population growth and rising economic prosperity will increase the demand for energy, food and water, with more severe impact in fast-growing economies, such as in several African countries. The constraints on water, energy, and food could well hamper economic development, lead to social and geopolitical tensions, and cause lasting environmental damage. DAFNE advocates an integrat ...
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 13

 EN COURS 

Film Colors. An Interdisciplinary Approach. (Filmcolors)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Film is in essence colored light projected onto a screen. Its aesthetics are thus highly determined by the material properties of film and the optical configuration of the cinematic apparatus. To this day, however, there is no systematic study of the relationship between the technology and aesthetics of film colors, despite the fact that, following the digital turn in film production and distribut ...
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 1

 EN COURS 
Healthspan (the life period when one is generally healthy and free from serious disease) depends on nature (genetic make-up) and nurture (environmental influences, from the earliest stages of development throughout life). Genetic studies increasingly reveal mutations and polymorphisms that may affect healthspan. Similarly, claims abound about lifestyle modifications or treatments improving healths ...
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 20

 EN COURS 

The Elusives Enterprise: Asymmetries of the Invisible Universe (ELUSIVES)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2020,

NEUTRINOS and DARK MATTER (DM) are the most abundant and also the most elusive building-blocks of nature because of their tenuous couplings to the ordinary matter we are made of. Each particle has a mirror image with identical mass and opposite charge: its antiparticle. What is the essential nature of particles and antiparticles? This is a most fundamental open question in science. The laws of phy ...
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 13

 EN COURS 
Although much has been done for developing technologies to bear upon problems of individuals with sensorimotor impairments, the impact of robotic aids on people with real needs in the real world is still very limited. Our main goal is to increase the cumulative benefits of assistive robotic technologies to society by enhancing their effectiveness AND the number of beneficiaries. The challenge is ...
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 13

 EN COURS 

Translating neuroimaging findings from research into clinical practice (PSYSCAN)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2020,

Abstract 9Neuroimaging (NI) has enormous potential to improve the clinical care of patients with psychiatric disorders, but has yet to deliver. The PSYSCAN project will address this issue directly by developing a NI-based tool that will help clinicians resolve key clinical issues in the management of patients with psychotic disorders. Clinicians will use the tool to assess patients with a standard ...
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 24

 EN COURS 

InvisiblesPlus

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2020,

NEUTRINOS (Ns) and DARK MATTER (DM) are the most abundant particles in the universe. Their couplings to ordinary matter are so tenuous that they remained undiscovered -invisible- until very recently. N masses and DM constitute the first evidence ever of physics beyond the Standard Model of particle physics. The path to build the New Standard Model must confront the fundamental nature of the partic ...
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 14

 EN COURS 

European Gram Negative Antibacterial Engine (ENABLE)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2020,

The intensive use and misuse of antibiotics has resulted in some level of antibiotic resistance in essentially all human bacterial pathogens. There is a growing concern that the loss of therapeutic options will present us with a post-antibiotic era where present and future medical advances are negated. Resistant bacteria dramatically reduce the possibilities of treating infections effectively, a ...
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 42

 EN COURS 

Deictic Communication - A Multidisciplinary Training (DCOMM)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2020,

Deictic communication is fundamental to understanding communication in both typical and atypical populations, and forms the key connection between language and objects/locations in the world. It is therefore critical to understanding human-human interaction, and human-system interaction in a range of technology applications – from mobile phones to cognitive robotics – and to the enhancement of cli ...
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 11

 TERMINÉ 

Accelerated Early staGe drug diScovery (AEGIS)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

The development of effective novel drugs - especially for rare and neglected diseases - is one of the biggest challenges of the upcoming decades, as illustrated by the recent Ebola outbreak. Moreover, European innovation in new drug registrations is dramatically falling behind compared to the US and Asia.The principal aim of the AEGIS ITN is to implement the first comprehensive, intersectoral cros ...
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 11