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 EN COURS 
artes EUmanities offers a doctoral programme (DP) with a mandatory mobility phase, as part of the established artes Graduate School for the Humanities Cologne (AGSHC). Designed around the needs of each individual Early Stage Researcher (ESR) in the Humanities, it will provide places for up to 10 ESRs every year for 3 years.EUmanities relies on a structured but flexible bottom-up approach, providin ...
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 1

 EN COURS 

The radiative interstellar medium (RadFeedback)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

The pressure, radiation, and ionization from the warm (UV emitting) and hot (X-ray emitting) gas has a significant impact on the cold, star-forming interstellar medium. We propose to carry out a comprehensive 3D study of the turbulent, multi-phase ISM in different environments that includes, for the first time, a proper treatment of UV and X-ray emission from stellar (primary) sources and extended ...
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 1

 EN COURS 
A fundamental question in neuroscience is to reveal the energy constrains governing the plasticity of brain circuits. Mitochondrial energy metabolism is increasingly recognized for regulating the activity and integrity of existing synaptic terminals, however it is unclear how changes in mitochondrial function are coupled with the generation of new neurons and the ensuing circuit remodelling, e.g. ...
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 2

 EN COURS 

Mediation of stem cell identity and aging by proteostasis (StemProteostasis)

Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,

By 2050, the global population over the age of 80 will triple. Thus, research for improving the quality of life at older age can be of enormous benefit for our ever-aging society. To address this challenge we propose an innovative approach based on a combination of stem cell research with genetic experiments in C. elegans. Mechanisms that promote protein homeostasis (proteostasis) slow down aging ...
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 1

 EN COURS 

Many-Body Physics with Driven Open Quantum Systems of Atoms, Light and Solids (DOQS)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2021,

Understanding the quantum many-particle problem is one of the grand challenges of modern physics. While tremendous progresses have been made over the past decades in thermodynamic equilibrium, nonequilibrium many-body quantum physics is still in its infancy. Strong motivation for addressing this challenge comes from recent experimental developments in diverse areas, ranging from cold atomic gases ...
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 1

 EN COURS 

Advanced Radio Astronomy in Europe (RadioNet)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

RadioNet is a consortium of 28 institutions in Europe, Republic of Korea and South Africa, integrating at European level world-class infrastructures for research in radio astronomy. These include radio telescopes, telescope arrays, data archives and the globally operating European Network for Very Long Baseline Interferometry (EVN). RadioNet is de facto widely regarded to represent the interests o ...
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 29

 EN COURS 

Boost Brittle Bones Before Birth (BOOSTB4)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Osteogenesis imperfecta (OI) is, in its severe forms, a devastating inherited disorder characterised by brittle bones. A person with severe OI is affected throughout their lifetime with repeated, multiple fractures, considerable pain and handicap. There is no curative or effective treatment for OI. Our preclinical studies and initial clinical cases have demonstrated that transplantation of fetal m ...
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 13

 EN COURS 
A well-functioning locomotor system is essential for human well-being. This is an important consideration in our aging population with the increased associated costs of ensuring high quality of life. Many people suffer from diseases of the locomotor system, such as bone defects or osteoarthritis, for which current treatments are insufficient. To develop new treatments, CarBon includes 6 academic p ...
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 9

 EN COURS 
As the number of older people in Europe grows, increasing healthy life years is a priority. Cognitive decline, dementia (e.g. Alzheimer’s disease, AD), sleep disturbances and depression, all related to psychological distress and anxiety, are significant drivers of reduced quality of life in older adults. This project builds on evidence that lifestyle factors and meditation practice have the potent ...
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 12

 EN COURS 

Antibody-Mediated Therapy of HIV-1 Infection (HIV1ABTHERAPY)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Antibodies are destined to neutralize pathogens and can prevent and fight infectious diseases. Over the last years, advances in single B cell cloning resulted in the isolation of highly potent and broad HIV-1 neutralizing antibodies (bNAbs) that have been shown to prevent SHIV infection in non-human primates (NHPs). Recently, we have demonstrated that a combination of bNAbs can suppress HIV-1 repl ...
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 2

 EN COURS 
The EN-ACTI2NG program (European Network on Anti-Cancer Immuno-Therapy Improvement by modification of CAR and TCR Interactions and Nanoscale Geometry) emanates from the recent clinical evidence that T cells expressing engineered tumor-specific immune receptors can eradicate certain tumors that do not respond to conventional treatment. To obtain T cells with reactivity to a wider array of tumors an ...
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 11

 TERMINÉ 
Large Polycyclic Aromatic Hydrocarbon (PAH) molecules are deeply interwoven in the fabric of the Universe and lock up ~15% of the elemental carbon in the interstellar medium (ISM) of galaxies. They dominate the mid-infrared emission characteristics of galaxies that can be used to trace star formation locally as well as in the early universe, they influence the phase structure of the ISM and the st ...
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 9

 TERMINÉ 

Regulation of mitochondrial expression (REMIX)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2020,

Mitochondria are essential organelles found in every eukaryotic cell, required to convert food into usable energy. The mitochondrial oxidative phosphorylation (OXPHOS) system, which produces the majority of cellular energy in the form of ATP, is controlled by two distinct genomes: the nuclear and the mitochondrial genome (mtDNA). Mutations in mitochondrial genes encoded by either genome could caus ...
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 9

 TERMINÉ 

Breast Cancer Risk after Diagnostic Gene Sequencing (BRIDGES) (BRIDGES)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Breast cancer affects more than 360,000 women per year in the EU and causes more than 90,000 deaths. Identification of women at high risk of the disease can lead to disease prevention through intensive screening, chemoprevention or prophylactic surgery. Breast cancer risk is determined by a combination of genetic and lifestyle risk factors. The advent of next generation sequencing has opened up th ...
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 20

 TERMINÉ 
It is still an open question how Earth became the rocky habitable planet as we know it today. This is because there is a significant time gap of several 100 million years between Earth’s oldest rock archives (ca. 4 billion years old) and most extraterrestrial samples like meteorites that archive the birth of our solar system ca. 4.5 billion years ago. Within this time gap, three key processes that ...
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 1

 TERMINÉ 
The goal of this project is to demonstrate that novel aspects of the molecular basis of Darwinian adaptation can be discovered if the polygenic basis of adaptation is taken into account. This project will use the genome-wide distribution of cis-regulatory variants to discover the molecular pathways that are optimized during adaptation via accumulation of small effect mutations. Current approaches ...
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 1

 TERMINÉ 

Reading Global. Constructions of World Literature and Latin America (RG)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

The debate on world literature is among the most significant cultural historical controversies of our time. This contribution to the debate aims to pursue two goals in particular:a) A groundbreaking theoretical approach to the current shift in focus of the concept of World Literature that will involve both the displacement of Eurocentric forms of knowledge and a comprehensive review of selection p ...
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 1

 TERMINÉ 

Many-body physics and superconductivity in 2D materials (SUPER-2D)

Date du début: 1 juin 2015, Date de fin: 31 mai 2020,

The goal of this project is to prepare and functionalize layered materials and then to characterize them in-situ using a novel combination of electrical transport, photoelectron and optical spectroscopy. This approach provides a solution to the intense research efforts in trying to engineer, probe and unravel many-body physics and the superconducting coupling mechanism in layered solids. The mater ...
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 1

 TERMINÉ 
Enhancers control the correct spatio-temporal activation of gene expression. A comprehensive characterization of the properties and regulatory activities of enhancers as well as their target genes is therefore crucial to understand the regulation and dysregulation of differentiation, homeostasis and cell type specificity.Genome-wide chromatin assays have provided insight into the properties and co ...
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 4

 TERMINÉ 

European Nuclear Science and Application Research 2 (ENSAR2)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

ENSAR2 is the integrating activity for European nuclear scientists who are performing research in three of the major subfields defined by NuPECC: Nuclear Structure and Dynamics, Nuclear Astrophysics and Nuclear Physics Tools and Applications. It proposes an optimised ensemble of Networking (NAs), Joint Research (JRAs) and Transnational Access Activities (TAs), which will ensure qualitative and qua ...
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 31

 TERMINÉ 

Combatting Bacterial Resistance in Europe - Carbapenem Resistance (COMBACTE-CARE)

Date du début: 1 mars 2015, Date de fin: 28 févr. 2020,

Multi-drug resistant Gram-negative bacteria (MDR-GNB): the ultimate challenge!Antibiotic resistance is a global public health concern recently elevated to the top three threats identified by the WHO, and subject of numerous national and international government activities. Although focused strategies have beneficially influenced infection rates due to methicillin resistant Staphylococcus aureus (M ...
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 23

 TERMINÉ 

Combatting Bacterial Resistance in Europe (COMBACTE-NET)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2019,

The emergence of Antibiotic-resistant bacteria (ARB) is a global problem, having recently been elevated to the top three threats identified by the World Health Organisation (WHO), and subject of numerous national and international government activities, including the Trans-Atlantic Task Force on Antimicrobial Resistance established by the US and EU presidencies. The estimated costs of ARB are aro ...
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 38

 TERMINÉ 
Over 30 million Europeans are blind or visually impaired, leading to reduced quality of life and a tremendous loss of productivity in society. Corneal blindness is the second largest cause of blindness globally and while treatable, millions remain unnecessarily blind due to issues of access to transplantable tissue, lack of standardized treatments, and the lag in translating new regenerative medic ...
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 14

 TERMINÉ 

Jean Monnet Chair for Teaching Turkey and European Union Studies

Date du début: 1 sept. 2016, Date de fin: 31 août 2019,

Reason:Considering the new phase in EU-Turkey relations since autumn 2015, the reason of MONTEUS is to promote research-based teaching with a focus on this increasingly important subject. MONTEUS answers the need for high-quality courses and publications on EU-Turkey relations and for mentoring promising academics in research and teaching.Output:MONTEUS’ main output is its researched-based teachin ...
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 1

 TERMINÉ 
Accumulation of damaged and aggregated proteins is associated with age-related neurodegeneration in Alzheimer’s and Parkinson’s patients. The ubiquitin/proteasome system (UPS) is a major proteolytic route functioning in a cellular network that maintains the proteome during stress and aging. Degradation of damaged proteins is mediated by the 26S proteasome upon attachment of ubiquitin (Ub) proteins ...
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 1

 TERMINÉ 
Insects are the most diverse Class of life on earth, and different insects can be essential for, or highly damaging to, agriculture, horticulture and forestry. There is a pressing need, not just for new insecticides to combat resistance, but more specific, “greener” insecticides that target deleterious insects while sparing beneficial ones. This proposal aims to identify such insecticides by turni ...
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 16

 TERMINÉ 

Archaeological Automatic Interpretation and Documentation of cEramics (ArchAIDE)

Date du début: 1 juin 2016, Date de fin: 31 mai 2019,

The objectives of ArchAIDE are to support the classification and interpretation work of archaeologists with innovative computer-based tools, able to provide the user with features for the semi-automatic description and matching of potsherds over the huge existing ceramic catalogues. Pottery classification is of fundamental importance for the comprehension and dating of the archaeological contexts, ...
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 9

 TERMINÉ 

Automorphic q-series and their application (AQSER)

Date du début: 1 janv. 2014, Date de fin: 30 avr. 2019,

This proposal aims to unravel mysteries at the frontier of number theory and other areas of mathematics and physics. The main focus will be to understand and exploit “modularity” of q-hypergeometric series. “Modular forms are functions on the complex plane that are inordinately symmetric.” (Mazur) The motivation comes from the wide-reaching applications of modularity in combinatorics, percolation, ...
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 1

 TERMINÉ 

Aerosols, Clouds, and Trace gases Research InfraStructure (ACTRIS-2)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2019,

ACTRIS-2 addresses the scope of integrating state-of-the-art European ground-based stations for long term observations of aerosols, clouds and short lived gases capitalizing work of FP7-ACTRIS. ACTRIS-2 aims to achieve the construction of a user-oriented RI, unique in the EU-RI landscape. ACTRIS-2 provides 4-D integrated high-quality data from near-surface to high altitude (vertical profiles and t ...
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 32

 TERMINÉ 
The EU and Turkey face mounting challenges both in relation to one another and internationally. The EU is confronted with an economic crisis which is likely to make differentiation a growing phenomenon. Turkey faces polarisation between different political forces, the state and civil society. The neighbourhood is unravelling to the east and south and a power shift is under way at global level. Thi ...
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 15

 TERMINÉ 

Costs and optimality of gene expression levels in Escherichia coli (OPTEX)

Date du début: 1 févr. 2017, Date de fin: 31 janv. 2019,

The precise expression of protein coding genes is of crucial importance to all organisms, since proteins are involved in virtually all vital processes. Some proteins need to be available at exactly the right amount to perform cellular functions sustainably and thereby maximize fitness. Consequently, gene expression needs to be accurately controlled. For these reasons, it has been hypothesized that ...
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 1

 TERMINÉ 
We concur to the IMI on “Reclassification of SLE, connective tissue diseases and RA” call by presenting a proposal aimed at using the power of OMICs, and bioinformatics to identify new classifications for diseases known to share common pathophysiological mechanisms. Such knowledge has not been applied to individual patients, depriving them from potential benefits in terms of the use of new therape ...
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 30

 TERMINÉ 

Rome's Mediterranean Ports (ROMP)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

Rome was connected to its Mediterranean provinces by commercial routes articulated through networks of ports acting as poly-functional nodes. Ships, people and goods moved along these, drawing the micro-regions of the Mediterranean into closer economic and commercial relationships with the City. Central to the success of these networks were the major ports through which were channelled major comme ...
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 6

 TERMINÉ 
ReDSHIFT will address barriers to compliance for spacecraft manufacturers and operators presented now and in the future by requirements and technologies for de-orbiting and disposal of space objects. This will be achieved through a holistic approach that considers from the outset opposing and challenging constraints for the safety of the human population when these objects re-enter the atmosphere, ...
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 13

 TERMINÉ 

Peptide-Drug Conjugates for Targeted Delivery in Tumor Therapy (MAGICBULLET)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

Many tumor cells are characterized by the overexpression of certain antigens. Molecules that specifically recognize these structures are suitable as homing devices in tumor therapy. Conjugates of anticancer drugs with such a delivery vector targeting tumors would be a “magic bullet” according to the Nobel laureate Paul Ehrlich. Three antibody-drug conjugates (ADC) have already been approved for an ...
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 9

 TERMINÉ 

Community as Opportunity - Creative archives' and users' network

Date du début: 1 déc. 2014, Date de fin: 30 nov. 2018,

All activities and undertakings within this project are tailored to specifically meet the Programmes’ targets of audience development and professionalization of players in the cultural sector. The core purpose of given project is to facilitate the mutual relationship between archives and archivists and the general public across the population stratum. This connecting and equating of archival insti ...
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 17

 TERMINÉ 

Personalised Prognostic Tools for Early Psychosis Management (PRONIA)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

Affective and non-affective psychoses have a major negative impact on human society. They account for 6.3% of the global burden of disease and cost €207 billion per year in Europe alone, making them the most expensive brain-related disorders and even more expensive than cardiovascular diseases. This socioeconomic burden is largely caused by two core disease features: onset in adolescence and early ...
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 13

 TERMINÉ 
DESIRE will focus on epileptogenic developmental disorders EDD, i.e. early onset epilepsies whose origin is closely related to developmental brain processes. A major cause of EDD are malformations of cortical development (MCD), either macroscopic or subtle. EDD are often manifested as epileptic encephalopathies (EE), i.e. conditions in which epileptic activity itself may contribute to severe cogni ...
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 29

 TERMINÉ 
"The aim of SYBIL is to carry out extensive functional validation of the genetic determinants of rare and common skeletal diseases and the age related factors contributing to these painful conditions. To achieve this goal SYBIL will gather complementary translational and transnational scientists, systems biologists, disease modellers, leading SMEs and industrialists that will perform in-depth char ...
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 19

 TERMINÉ 
Adult immigrants require literacy and numeracy in the language of the community to participate in the economic and social life of that community. While many post-industrialized countries fund programmes to actively support the development of immigrants’ basic and more advanced literacy skills, in most of these countries, there is no specific training and development for teachers who work with the ...
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 7