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Engineering of new-generation protein secretion systems (ProteinFactory)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

The market for recombinant proteins, including biopharmaceuticals, industrial enzymes and membrane proteins, is estimated to be about 78 billion Euro and rising. A high proportion of the target proteins are produced in bacteria, where secretion out of the cytoplasm is a favoured strategy. However, current production platforms have severe limitations and cannot handle many secreted enzymes and memb ...
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Foldamers against protein-protein interactions (FOLDAPPI)

Date du début: 1 févr. 2009, Date de fin: 31 janv. 2014,

... tance as a drug target, no small molecule inhibitor of the Il-4/IL-4R has been reported so far, warranting the use of foldamers to do the same. The three partners involved in this cooperation, namely UCB Pharma, Université Bordeaux I and Universität Würzburg each have unique expertises necessary to bring this project to completion. This combination will produce breakthrough knowledge and insights ...
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