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 EN COURS 
The new challenge in global health is to achieve Universal Health Care (UHC) by 2030. Having an adequate workforce is critical to achieving UHC. Efforts are in place to scale up the numbers of health workers. Improving health workforce performance is equally important as the quantity of health workers, but more challenging. Workforce performance improvement can be achieved better at management ...
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 7

 EN COURS 
Chronic aortic aneurysms are permanent and localized dilations of the aorta that remain asymptomatic for long periods of time but continue to increase in diameter before they eventually rupture. Left untreated, the patients’ prognosis is dismal, since the internal bleeding of the rupture brings about sudden death. Although successful treatment cures the disease, the risky procedures can result in ...
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 26

 EN COURS 
Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte ...
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 44

 EN COURS 

Dynamic responsive porous crystals (DYNAPORE)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,

The project addresses the long-term vision of man-made materials with chemical selectivity and functional efficiency produced by dynamic structural flexibility. These materials are not intended as protein mimics; they are however inspired by nature’s use of flexible rather than rigid systems, with their ability to dynamically restructure around guests and thus perform highly specific chemistry. Su ...
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 1

 EN COURS 

Travel, Transculturality and Identity in England, c.1550 – 1700 (TIDE)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,

The central research question this project will pose is: how did mobility in the great age of travel and discovery (c.1550–1700) shape English perceptions of human identity based on cultural identification and difference? The role of those marked by transcultural mobility was central to this period. Our current world is all too familiar with the concepts that surfaced or evolved as a result: ‘fore ...
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 1

 EN COURS 
Failure of large complex engineering systems often leads to catastrophic consequences. Their efficient and safe design and operation will avoid or reduce malfunctions, failures and accidents, which would have a significant impact on the daily life of the public in terms of service and product delivery, business interruption, economic losses, human injuries/fatalities, and property and environmenta ...
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 5

 EN COURS 

ARgon ImAging DetectioN chambEr (ARIADNE)

Date du début: 1 mars 2016, Date de fin: 28 févr. 2021,

This proposal outlines a plan to combine Charge Couple Device (CCD) camera technologies with two-phase Liquid Argon Time Projection Chambers (LAr TPCs) utilising THick Gas Electron Multipliers (THGEMs) to evolve a next generation neutrino detector. This will be an entirely new readout option, and will open the prospect of revolutionary discoveries in fundamental particle physics. Furthermore, the ...
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 1

 EN COURS 

Innovative Nanowire DEvicE Design (INDEED)

Date du début: 1 févr. 2017, Date de fin: 31 janv. 2021,

Nanowires (NWs) exhibit unique properties that make them potential building blocks for a variety of next generation NanoElectronics devices. Recent advances have shown that NWs with predefined properties can be grown, offering a new paradigm enabling functional device prototypes including: biosensors, solar cells, transistors, quantum light sources and lasers. The critical mass of scientific knowl ...
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 12

 EN COURS 

A sound fundament for our future buildings (Acoutect)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

To ensure a healthy environment for people living and working in buildings, research and engineering in the area of building acoustics is essential. Developments in modern building concepts, such as sustainable low-energy consuming buildings, buildings with lightweight materials and open plan working environments, as well as the need to build in extremely noisy areas, require involvement of acoust ...
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 10

 EN COURS 
The advancement of project management (PM) knowledge and the development of PM capability of people is crucial to the successful delivery of projects. As the overall project-related spending in the EU is assumed to be about € 3.27 trillion there are huge societal and economic challenges of reducing the massive financial and psychological costs of poor project delivery. Especially as about 6% of al ...
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 9

 EN COURS 

Optical Infrared Coordination Network for Astronomy (OPTICON)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Europe has become a global leader in optical-near infrared astronomy through excellence in space and ground-based experimental and theoretical research. While the major infrastructures are delivered through major national and multi-national agencies (ESO, ESA) their continuing scientific competitiveness requires a strong community of scientists and technologists distributed across Europe’s nations ...
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 34

 EN COURS 

Paediatric Clinical Research Infrastructure Network (PedCRIN)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Children’s health is a major societal challenge for Europe and the world, requiring development of paediatric medicines and treatments strategies based on evidence derived from clinical trials demonstrating efficacy and safety in infants and children, rather than on uncritical extrapolation from adult data (over 50 % of the medicines used for children had not been tested in this specific age group ...
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 16

 EN COURS 
ArrestAD proposes a novel and visionary thinking resulting from the demonstration of the central role of a particular heparan sulfate species at the intracellular level in neurons and in circulating cells in the molecular pathology of Alzheimer’s disease (AD). AD is a societal challenge for which there is neither prevention nor possible cure. Research in the field has long been refining classic co ...
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 8

 EN COURS 
The management of febrile patients is one of the most common and important problems facing healthcare providers. Distinction between bacterial infections and trivial viral infection on clinical grounds is unreliable, and as a result innumerable patients worldwide undergo hospitalization, invasive investigation and are treated with antibiotics for presumed bacterial infection when, in fact, they ar ...
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 19

 EN COURS 
All chemicals whether they are drugs, cosmetics, agrochemicals or others need to be tested for their safety to man and the environment. The use of whole animal studies for the prediction of adverse effects in man, is problematic due to species dependent effects, high costs and a large burden to animals in terms of numbers and suffering. While there have been major improvements in human in vitro a ...
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 14

 EN COURS 

Accelerators Validating Antimatter physics (AVA)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Antiprotons, stored and cooled at low energies in a storage ring or at rest in traps, are highly desirable for the investigation of basic questions on fundamental interactions, the static structure of antiprotonic atoms, CPT tests by high-resolution spectroscopy on antihydrogen, as well as gravity experiments. Antimatter experiments are at the cutting edge of science. They are, however, very diffi ...
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 11

 EN COURS 
Many HIV vaccine concepts and several efficacy trials have been conducted in the prophylactic and therapeutic fields with limited success. There is an urgent need to develop better vaccines and tools predictive of immunogenicity and of correlates of protection at early stage of vaccine development to mitigate the risks of failure. To address these complex and challenging scientific issues, the Eur ...
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 43

 EN COURS 
Pharmacogenomics is the study of genetic variability affecting an individual’s response to a drug. Its use allows personalized medicine and reduction in ‘trial and error’ prescribing leading to more efficacious, safer and cost-effective drug therapy. The U-PGx consortium will investigate a pre-emptive genotyping approach (that is: multiple pharmacogenomic variants are collected prospectively and ...
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 16

 EN COURS 

New therapies for uveal melanoma (UM Cure 2020)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Uveal melanoma (UM) is a rare intraocular tumour with an incidence of 5 cases per million individuals per year. Up to 50% of UM patients develop metastases, most often in the liver, and these are invariably fatal. Despite new discoveries in the genetic and molecular background of the primary tumour, little is known about the metastatic disease; furthermore, there is no therapy to either prevent or ...
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 13

 EN COURS 

Network for Innovative Training on ROtorcraft Safety (NITROS)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2020,

Helicopters and the other vertical flight vehicles, like tilt-rotors, compound helicopters, hybrids and rapidly expanding class of easy to fly vertical take-off personal vehicles, are expected to see widespread use in the future especially as means of transport, exploiting the formidable capability to provide point-to-point connections.However, if the expansion of the usage of rotorcraft vehicles ...
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 4

 TERMINÉ 
Increasingly challenging global and environmental requirements have resulted in agricultural systems coming under increasing pressure to enhance their resilience capabilities in order to respond to the abrupt changes in resource quality, quantity and availability, especially during unexpected environmental circumstances, such as uncertain weather, pests and diseases, volatile market conditions and ...
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 15

 TERMINÉ 
Large Polycyclic Aromatic Hydrocarbon (PAH) molecules are deeply interwoven in the fabric of the Universe and lock up ~15% of the elemental carbon in the interstellar medium (ISM) of galaxies. They dominate the mid-infrared emission characteristics of galaxies that can be used to trace star formation locally as well as in the early universe, they influence the phase structure of the ISM and the st ...
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 9

 TERMINÉ 
This project will generate the first ever theoretically and empirically-grounded comparative and comprehensive picture of the status and legal experiences of asylum-seekers across Europe claiming international protection on the basis of their sexual orientation or gender identity (SOGI), and determine how the European asylum systems can treat more fairly asylum claims based on the claimant’s SOGI. ...
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 2

 TERMINÉ 
Globular clusters (GCs) are among the oldest luminous sources in the universe, bearing witness to the earliest stages of galaxy formation as well as their evolution to the present day. While GCs have played a pivotal role in our understanding of the assembly of galaxies, their full potential remains unfulfilled due to our lack of understanding of how they form. One of the largest stumbling blocks ...
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 1

 TERMINÉ 

Nanoencapsulation for Energy Storage and Controlled Release (ENERCAPSULE)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

The main vision of the project ENERCAPSULE is the development of nanoencapsulation technologies based on switchable nanoscale barriers for novel generation of controlled energy storage and delivery systems. These systems will be based on the “smart” nanocontainers (size below 200 nm) loaded with the energy-enriched active components: materials for thermal energy (both latent and based on chemical ...
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 1

 TERMINÉ 
How children acquire their native language remains one of the key unsolved problems in Cognitive Science. This project will answer a question that lies at the heart of this problem: How do children acquire the abstract generalizations that allow them to produce novel sentences, while avoiding the ungrammatical utterances that result from across-the-board application of these generalizations (e.g., ...
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 4

 TERMINÉ 

Partnership for Research in Geopolymer Concretes (PRIGeoC)

Date du début: 1 juin 2016, Date de fin: 31 mai 2020,

Concrete, owing to its availability, easy preparation and fabrication, is the most popular construction material. However, the cement industry is facing unprecedented challenges caused by energy resources and CO2 emissions. Despite the incremental improvements in process efficiency adopted by the cement industry in recent years, OPC production is still responsible for around 6% of all man-made glo ...
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 3

 TERMINÉ 
ATLAS creates a dynamic new partnership between multinational industries, SMEs, governments and academia to assess the Atlantic’s deep-sea ecosystems and Marine Genetic Resources to create the integrated and adaptive planning products needed for sustainable Blue Growth. ATLAS will gather diverse new information on sensitive Atlantic ecosystems (incl. VMEs and EBSAs) to produce a step-change in our ...
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 24

 TERMINÉ 

Methods in Research on Research (MIROR)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

Our aim is to create, in Europe, an innovative and ambitious multidisciplinary intersectoral joint doctoral training programme, dedicated to Methods in Research on Research (MIROR) in the field of clinical research. “Research on Research”, is an emerging new scientific discipline that aims to reduce waste in research and increase research value. Waste in research represents tens of billions of Eur ...
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 7

 TERMINÉ 
... program, both early stage and advanced researchers will be seconded from the academic eight teams to these four SMEs and vice versa. Thereby, this RISE scheme will establish a long-term collaborative University-SME driven translational innovative research program innovation in our interdisciplinary field of growing socioeconomic medical importance.
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 14

 TERMINÉ 

European Nuclear Science and Application Research 2 (ENSAR2)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

ENSAR2 is the integrating activity for European nuclear scientists who are performing research in three of the major subfields defined by NuPECC: Nuclear Structure and Dynamics, Nuclear Astrophysics and Nuclear Physics Tools and Applications. It proposes an optimised ensemble of Networking (NAs), Joint Research (JRAs) and Transnational Access Activities (TAs), which will ensure qualitative and qua ...
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 31

 TERMINÉ 

Preventing and mitigating farmed bivalve diseases (VIVALDI)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

The overarching goal of VIVALDI is to increase the sustainability and competitiveness of the European shellfish industry by improving the understanding of bivalve diseases and by developing innovative solutions and tools for the prevention, control and mitigation of the major pathogens affecting the main European farmed shellfish species: Pacific oyster (Crassostrea gigas), mussels (Mytilus edulis ...
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 21

 TERMINÉ 
The calcium sensing receptor (CaSR) is a class C Gprotein-coupled receptor that plays a pivotal role in systemic calcium metabolism by regulating parathyroid hormone secretion and urinary Ca excretion. Abnormal CaSR function is implicated in calciotropic disorders, and in non-calciotropic disorders such as Alzheimer’s disease (AD), cardiovascular disease (CVD), diabetes (DM), sarcopenia and cancer ...
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 13

 TERMINÉ 

Optimization of Medical Accelerators (OMA)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2020,

Cancer is a major social problem, and it is the main cause of death between the ages 45-65 years. In the treatment of cancer, radio therapy (RT) plays an essential role. RT with hadrons (protons and light ions), due to their unique physical and radiobiological properties, offers several advantages over photons for specific cancer types. In particular, they penetrate the patient with minimal diffus ...
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 14

 TERMINÉ 
Malaria is a life-threatening disease causing more than 500,000 deaths every year in sub-Saharan Africa. Prevention of the disease is best achieved by vector control which relies on the use of insecticides. Monitoring mosquito vector populations is an integral component of control programmes and a prerequisite for effective interventions. Several individual methods are used for this task, However, ...
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 10

 TERMINÉ 
Background In a world with increasing demand for food and energy, effective and long-lasting animal control is crucial. Animals are drawn to agricultural areas for food, but this leads to consequences for both animals and farmers. Chemical poisons are often used to control rodent populations in areas where they destroy crops, eat livestock feed and can tr ...
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 8

 TERMINÉ 
Our proposal encompasses parallel clinical trials addressing the feasibility and the effectiveness of donor-derived regulatory T cells (Treg) as a therapeutic agent in the treatment and prevention of tissue and organ damage resulting from graft versus host disease (GVHD) after hematopoietic stem cell transplantation (HSCT).We propose a collaborative clinical study in which Treg therapy for GHVD is ...
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 8

 TERMINÉ 

Muon campus in US and Europe contribution (MUSE)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

The Muon Campus at FNAL, USA, will host in the next few years two world class experiments dedicated to the search for signals of new physics. Muon g-2 will determine with unprecedented precision the anomalous magnetic moment of the muon while Mu2e will improve by four orders of magnitude the sensitivity on the search for the as-yet unobserved Charged Lepton Flavour Violating process of a neutrinol ...
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 7

 TERMINÉ 
Environmental microbial surveys have revealed a remarkable diversity of microeukaryotic life in most ecosystems, the majority of which had previously escaped detection. From an ecological point of view this work highlighted our ignorance of critical microbial players in natural environmental processes, including primary production, biogeochemical cycling and trophic interactions such as parasitism ...
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 9

 TERMINÉ 
EuPRAXIA will produce a conceptual design report for the worldwide first 5 GeV plasma-based accelerator with industrial beam quality and user areas. EuPRAXIA is the required intermediate step between proof-of-principle experiments and ground-breaking, ultra-compact accelerators for science, industry, medicine or the energy frontier (“plasma linear collider”). The study will design accelerator tech ...
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 17