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 EN COURS 
The complex interactions between genetic and non-genetic factors produce heterogeneities in patients as reflected in the diversity of pathophysiology, clinical manifestations, response to therapies, disease development and progression. Yet, the full potential of personalized medicine entails biomarker-guided delivery of efficient therapies in stratified patient populations.MultipleMS will therefor ...
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 25

 EN COURS 

Moduli of Crystals and K3 Surfaces (K3CRYSTAL)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,

Algebraic geometry deals with algebraic varieties, that is, systems of polynomial equations and their geometric interpretation. Its ultimate goal is the classification of all algebraic varieties. For a detailed understanding, one has to construct their moduli spaces, and eventually study them over the integers, that is, in the arithmetic situation. So far, the best results are available for curves ...
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 1

 EN COURS 

Algorithmic Performance Guarantees: Foundations and Applications (APEG)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,

Optimization problems are ubiquitous in computer science. Almost every problem involves the optimization of some objective function. However a major part of these problems cannot be solved to optimality. Therefore, algorithms that achieve provably good performance guarantees are of immense importance. Considerable progress has already been made, but great challenges remain: Some fundamental proble ...
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 1

 EN COURS 
Antibodies secreted by B cells of the adaptive immune system establish an essential barrier against bacteria and viruses and their presence is the hallmark of protective vaccinations. B cells are licensed for their tasks during germinal center (GC) reactions and differentiation into antibody-secreting plasma cells. Unfortunately, B cell-derived autoantibodies and proinflammatory cytokines can caus ...
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 2

 EN COURS 
B-cell malignancies are characterized by high levels of genomic instability, which critically contribute to their pathogenesis and evolution. Recently, the fundamental role of the ubiquitin proteasome system (UPS) in maintaining genome integrity has been appreciated. Two major new therapeutic modalities in B-cell malignancies, proteasome inhibitors and imunomodulatory drugs (IMiDs), target the UPS ...
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 2

 EN COURS 

Respiratory Disease Screening with Dark-Field Computed Tomography (RespeCT)

Date du début: 1 août 2016, Date de fin: 31 juil. 2021,

The grand goal of this proposal is to translate a recently explored and fundamentally different x-ray contrast mechanism, namely x-ray dark-field imaging, from present in-vivo small-animal proof-of-principle studies to a first clinical dark-field computed tomography (CT) prototype for future human diagnostics. Complementing this main technological development goal, we will explore the potential fu ...
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 1

 EN COURS 

Individualised medicine in chronic inflammatory skin diseases (IMCIS)

Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,

More than 100 million EU citizens suffer from chronic inflammatory skin diseases such as psoriasis and atopic eczema (AE). The diseases imply a devastating life quality similar to that of cancer, and cause direct socio-economic costs in the magnitude of 100 billion Euro each year in the EU. Despite all efforts, psoriasis and AE remain undertreated and the concept of individualised (also called pre ...
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 2

 EN COURS 

Amorphous and Evolutionary DNA Nanotechnology (AEDNA)

Date du début: 1 juin 2016, Date de fin: 31 mai 2021,

Amorphous and evolutionary DNA nanotechnology (AEDNA) explores novel conceptual directions and applications for DNA nanotechnology, which are based on intelligent, DNA-programmed soft hybrid materials, and the utilization of evolutionary principles for the optimization of nucleic acid nanocomponents.Amorphous DNA nanotechnology first aims at the creation of cell-sized, DNA-programmed microgels – D ...
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 1

 EN COURS 

Magnetic resonance imaging platform for probing fat microstructure (ProFatMRI)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2021,

Metabolic syndrome and osteoporosis are the two metabolic diseases with the highest and most rapidly growing prevalence, transforming them into a major global health and socioeconomic concern. Metabolic syndrome can be diagnosed with established biomarkers, but the selection of optimal prevention strategies for each individual patient is still problematic. Osteoporosis can be treated, but its curr ...
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 2

 EN COURS 
Multispectral Optoacoustic Tomography (MSOT) brings a revolution to bio-optical imaging. Being insensitive to photon scattering, MSOT dramatically improves upon conventional bio-optic barriers by enabling (1) three-dimensional high-resolution optical imaging deep inside tissues (several millimetres to centimetres), by (2) high-scalability, ranging from optical-resolution microscopy to acoustic-res ...
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 6

 EN COURS 
“Joining up Users for Maximising the Profile, the Innovation and the Necessary Globalisation of JIVE” (JUMPING JIVE) aims to prepare and position European Very Long Baseline Interferometry (VLBI) for the SKA era, and to secure the role of JIV-ERIC in the European and global landscape of Research Infrastructures. On a European scale, the proposed activities will raise the profile of JIVE among scie ...
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 13

 EN COURS 

Smart and Inclusive Solutions for a Better Life in Urban Districts (SMARTER TOGETHER)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2021,

SMARTER TOGETHER’s overarching vision is to find the right balance between smart technologies and organizational/ governance dimensions in order to deliver smart and inclusive solutions and to improve citizen’s quality of life.SMARTER TOGETHER gather the European Lighthouse cities Lyon, Munich, Vienna, the Follower cities Santiago de Compostela, Sofia, Venice and Kyiv and Yokohama as observer citi ...
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 30

 EN COURS 

Next-generation in vivo models for improved pancreatic cancer therapies (PanCaT)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2021,

Maintenance and drug resistance of pancreatic ductal adenocarcioma (PDAC) depends on cancer cell intrinsic mechanisms and a stroma that supports tumor growth. Mouse models of human PDAC have provided important insights into the evolution of this highly lethal tumor, but there are no models that allow secondary genetic manipulation of autochthonous tumors, the tumor microenvironment or the metastat ...
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 2

 EN COURS 
Molecular in vitro diagnostics and biomedical research have allowed great progress in personalised medicine but further progress is limited by insufficient guidelines for pre-analytical workflow steps (sample collection, preservation, storage, transport, processing etc.) as well as by insufficient quality assurance of diagnostic practice. This allows using compromised patients’ samples with post c ...
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 21

 EN COURS 
Two-dimensional materials (2DMs) such as graphene, hexagonal boron nitride, silicene and others, are currently amongst the most intensively studied classes of materials that hold great promise for future applications in many technological areas. However, the main hurdle against practical utilization of 2DMs is the lack of effective mass production techniques to satisfy the growing qualitative and ...
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 7

 EN COURS 

SiliconLaser (SiLAS)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Our research aims to revolutionize the electronics industry by adding intra-chip and chip-to-chip communication at the speed of light, offering a significantly reduced energy consumption. Cubic crystal phase SiGe is known to be great for electronics. We propose to develop hexagonal crystal phase SiGe (Hex-SiGe) which features a direct bandgap and will add photonic capabilities to electronics. Dire ...
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 6

 EN COURS 

ACCELERATing Europe's Leading Research Infrastructures (ACCELERATE)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

CERIC-ERIC (CERIC) is a distributed research infrastructure for fundamental and applied research on novel materials and biomaterials. The RI has been in operation for 2 years and provides open access to a broad range of instruments and expertise across research communities, in order to support the research community world-wide in tackling the most challenging problems of materials research. The A ...
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 8

 EN COURS 
Stroke and dementia rank among the most pressing health issues in Europe. Cerebral small vessel diseases (SVDs) have emerged as a central link between these two major co-morbidities. SVDs account for more than 30% of strokes and at least 40% of dementia cases. They encounter multiple distinct diseases that can be separated based on their underlying genetic defects, risk factors, and clinical prese ...
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 14

 EN COURS 

Enantioselective Light-induced Catalysis for Organic Synthesis (ELICOS)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Photochemical reactions are induced by ultraviolet or visible light and they enable the construction of molecular skeletons that are difficult or even impossible to access by any other means. In order to secure a widespread application of these reactions in organic synthesis and in order to make the respective products available for high-tech applications, it is required that photochemical reactio ...
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 1

 EN COURS 

Composable Models and Software for Robotics Systems (RobMoSys)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

RobMoSys will coordinate the whole community’s best and consorted effort to build an open and sustainable, agile and multi-domain European robotics software ecosystem.RobMoSys envisions an integration approach built on-top-of, or rather around, the current code-centric robotic platforms, by means of the systematic application of model-driven methods and tools that explicitly focus on (system-of-) ...
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 9

 EN COURS 
This ERC-StG 2014 proposal, SILION, outlines a strategy for the one-pot synthesis, characterization, and reactivity investigation of a positively charged, electron-deficient, highly Lewis acidic, cationic silicon(II) species, denoted “silyliumylidene ions”. Silyliumylidene ion has only four valence electrons, consisting of a lone pair of electrons and two vacant orbitals on the central silicon ato ...
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 2

 EN COURS 

Manufacturing Shock Interactions for Innovative Nanoscale Processes (NANOSHOCK)

Date du début: 1 déc. 2015, Date de fin: 30 nov. 2020,

Fluid dynamics are fundamental to a wide spectrum of natural phenomena and technological applications. Among the most intriguing fluid dynamics events are shockwaves, discontinuities in the macroscopic fluid state that can lead to extreme temperatures, pressures and concentrations of energy.The violence and yet the spatial localization of shockwaves presents us with a unique potential for in situ ...
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 1

 EN COURS 
CRESCENDO brings together seven Earth System Modelling (ESM) groups with three Integrated Assessment Modelling teams, as well as experts in ESM evaluation, ESM projection and feedback analysis, climate impacts and science communication to address the following goals; (i) improve the process-realism and simulation-quality of European ESMs in order to increase the reliability of future Earth system ...
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 25

 EN COURS 

Fishfriendly Innovative Technologies for Hydropower (FIThydro)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2020,

FIThydro addresses the decision support in commissioning and operating hydropower plants (HPP) by use of existing and innovative technologies. It concentrates on mitigation measures and strategies to develop cost-efficient environmental solutions and on strategies to avoid individual fish damage and enhancing population developments. Therefore HPPS all over Europe are involved as test sites. The f ...
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 26

 TERMINÉ 
European forests are expected to provide a broad range of ecosystem services (ES). This capacity is however threatened by the uncertainties of climate change, the complex dynamics of evolving global markets and the pressures for increased use of bioenergy. Such challenges cannot be effectively addressed with an uncritical regional or national commitment to traditional forest management models (FMM ...
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 21

 TERMINÉ 

Multimodal, Functional Bio-Photonic Imaging (FBI)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2020,

FBI fosters education of ESRs on an emerging, multimodal imaging platform and its translation into clinical and biological applications. In FBI, 15 ESRs are trained at world-leading European academic institutions and companies, thus forming strong interdisciplinary relations between industry, technical sciences and clinical end-users.Optical imaging has huge potential to address unmet clinical nee ...
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 10

 TERMINÉ 

Quantifying Flexibility in Communication Networks (FlexNets)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Communication networks have emerged to become the basic infrastructure for all areas of our society with application areas ranging from social media to industrial production and healthcare. New requirements include the need for dynamic changes of the required resources, for example, to react to social events or to shifts of demands. Existing networks and, in particular, the Internet cannot meet th ...
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 1

 TERMINÉ 
Abiotic stresses, such as drought or salt stress, affect plant growth and threaten the capacity to feed a growing world population. Understanding and altering how plants deal with stress will be critical for society’s adaptation to a changed climate. I propose a novel systems-biology based approach to identify biotechnological targets based on comparison of interaction and signalling networks of e ...
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 1

 TERMINÉ 

3D Reloaded: Novel Algorithms for 3D Shape Inference and Analysis (3D Reloaded)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Despite their amazing success, we believe that computer vision algorithms have only scratched the surface of what can be done in terms of modeling and understanding our world from images. We believe that novel image analysis techniques will be a major enabler and driving force behind next-generation technologies, enhancing everyday life and opening up radically new possibilities. And we believe th ...
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 1

 TERMINÉ 
Batteries are not yet the ideal energy container they were promised to be. They are expensive, fragile and potentially dangerous. Moreover the current EV cannot compete yet with traditional vehicles when it comes to driving range and flexibility. EVERLASTING intends to bring Li-ion batteries closer to this ideal by focusing on the following technology areas.• Predicting the behavior of battery ...
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 11

 TERMINÉ 
The cities of Madrid, Stockholm, Munich, Turku and Ruse have formed the CIVITAS ECCENTRIC consortium to tackle the challenges of mobility in suburban districts and clean, silent and CO2 free city logistics. In many cities, these two important areas have received less attention in urban mobility policies.Though European cities have made significant steps forward in making city centres attractive an ...
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 30

 TERMINÉ 
The incidence of autoimmune diseases including multiple sclerosis is dramatically increasing. While there is a genetically defined “bedrock” susceptibility to develop T cell mediated autoimmunity, environmental cues likely determine the threshold for disease development. Yet, little is known on how environmental cues sensed at body/environment interfaces are translated into immunopathology in dist ...
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 2

 TERMINÉ 
The proposal addresses novel concepts for introducing Robotics and Autonomous Systems in the Construction Sector where, at this moment, the presence is minor. Specifically, the Hephaestus project focuses on highly risked and critical construction tasks such as prefab wall installation. In that sense, the Hephaestus has been conceived as a solution for accomplishing multiple tasks on vertical or in ...
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 9

 TERMINÉ 
Chronic back pain is a major burden and source of disability worldwide. It is primarily attributed to biomechanical factors. In elderly patients, osteoporosis complicates the biomechanical scenario. Surgery is often required to treat instability-related pain and to restore the balance of the spine. However, when and how to perform surgery remains a highly subjective decision based on the surgeon’s ...
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 3

 TERMINÉ 
Arterial hypertension affects up to 45% of the general population and is responsible for 7.1 million deaths per year worldwide. Although a large therapeutic arsenal exists, blood pressure control is sub-optimal in up to two thirds of patients. Yet, even small increments in blood pressure are associated with increased cardiovascular risk, with 62% of cerebrovascular disease and 49% of ischemic hear ...
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 13

 TERMINÉ 
HORSE aims to bring a leap forward in the manufacturing industry proposing a new flexible model of smart factory involving collaboration of humans, robots, AGV’s (Autonomous Guided Vehicles) and machinery to realize industrial tasks in an efficient manner. HORSE proposes to foster technology deployment towards SMEs by developing a methodological and technical framework for easy adaptation of robot ...
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 15

 TERMINÉ 

Virtualization of Real Flows for Animation and Simulation (realFlow)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

Besides their application in a very broad range of engineering disciplines, physically-based simulations have become a prevalent tool for all forms of computer-generated environments. Simulations of fluids are a particularly important area that has applications ranging from the design of aerodynamic bodies to the realization of impressive visual effects in movies. However, despite their extremely ...
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 1

 TERMINÉ 

Attosecond Electron Dynamics in MOlecular Systems (AEDMOS)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

Advanced insight into ever smaller structures of matter and their ever faster dynamics hold promise for pushing the frontiers of many fields in science and technology. Time-domain investigations of ultrafast microscopic processes are most successfully carried out by pump/probe experiments. Intense waveform-controlled few-cycle near-infrared laser pulses combined with isolated sub-femtosecond XUV ( ...
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 1

 TERMINÉ 

Enhanced Delivery Ecosystem for Neurosurgery in 2020 (EDEN2020)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2020,

Due to an aging population and the spiralling cost of brain disease in Europe and beyond, EDEN2020 aims to develop the gold standard for one-stop diagnosis and minimally invasive treatment in neurosurgery. Supported by a clear business case, it will exploit the unique track record of leading research institutions and key industrial players in the field of surgical robotics to overcome the current ...
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 9

 TERMINÉ 
FlowerPower aims at establishing a new generation of horticulturists capable of exploiting plant genetic resources in an innovation oriented way using cutting edge technology. The co-operation between the professional horticultural industry, a research-oriented company in the field of functional genomics and scientists from five Universities from 3 countries addresses urgent needs in the non-acade ...
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 4