3 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
The subnuclear relocation of promoters during development, and following stress induction in C. elegans (WormProLoc)
Date du début: 1 janv. 2012, Date de fin: 7 mai 2014,
...ations, advanced biochemical methods that we will need to develop and quantitative live imaging approaches to address these questions.The work is proposed to be carried out under supervision of Prof. Susan Gasser, at the FMI institute which offers state-of-the-art facilities and provides excellent multi-disciplinary training and collaboration opportunities, thus providing the ideal environment for ...
Voir le projet
2
Participants partenaires
TERMINÉ
High Resolution Microscopy in the DNA Damage Response (Image DDR)
Date du début: 1 nov. 2008, Date de fin: 31 oct. 2012,
Background: The DNA damage response (DDR) is a specialised stress response fundamental to maintaining genome integrity and suppressing tumour formation. Traditional molecular and cellular biology, combined with genetics and biochemistry, have led to an understanding of the architecture of the DDR in a variety of model organisms and in human cells. These studies have employed populations of cells/ ...
Voir le projet
6
Participants partenaires
TERMINÉ
Regulating nuclear organisation in telomere maintenance and DNA repair: the role of SUMO modification (SUMO and chromatin)
Date du début: 1 mars 2008, Date de fin: 28 févr. 2010,
The organisation of the genome into separate domains and sub-compartments through higher order chromatin structure is an important means by which eukaryotic cells control nuclear processes such as DNA transcription and repair. Recent evidence has implicated sumoylation as an important regulator of global nuclear architecture as well as allied processes such as telomere maintenance and DNA damage r ...
Voir le projet