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Microtubule organizing centers and microtubule nucleation in mitosis (MTOC function)

Date du début: 21 juil. 2008, Date de fin: 20 juil. 2012,

Centrosomes are multifunctional organelles crucial for a large number of cellular functions including the organization of microtubules. In mitosis centrosomes contribute to assembly, orientation and function of the mitotic spindle, which is important for proper segregation of the chromosomes. Defects in centrosome number and function are strongly associated with the cancer phenotype and centrosome ...
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