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In the brain, blood flow increases locally upon neuronal activation, a response named functional hyperemia. The extent to which functional hyperemia faithfully reports brain activation, spatially or temporally, remains a matter of debate. Solving this question is important, not only because functional hyperemia supplies energy and clears metabolites from activated brain regions, but also because i ...

Neisseria meningitidis is still the major cause of bacterial meningitis and septicemia worldwide. The septic shock caused by Neisserial invasive disease is characterized by the presence of skin lesions (petecchial rashes and purpura). Despite the strong association of meningococcal disease and purpura as well as the serious prognosis associated with it, the bacterial factors and physiological proc ...