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Switching the disease off: Effects of spatial and temporal inactivation of mutant huntingtin in Huntington disease (SWITCH-HD)
Date du début: 1 mars 2013, Date de fin: 28 févr. 2017,
"Huntington Disease (HD) is an autosomal dominantly inherited neurodegenerative disorder, which is caused by an expanded CAG repeat in the huntingtin gene. Mutant Huntingtin (mhtt) is expressed ubiquitously in the brain but the most affected region is the striatum. Marked atrophy also occurs in other brain regions such as the cortex and the hypothalamus. The latter has been linked to disturbances ...
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