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9 projets européens trouvés

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 TERMINÉ 

To Notch up a broken heart (StressFate)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2018,

Heart failure is a major health issue and a cause of death and disability. The endogenous regenerative capacity of the heart is too weak to recover from damage and instead the heart repairs damage by synthesis of a scar tissue leading to functional deterioration. To improve cardiac regeneration, stem cell therapies and material-based approaches have been developed but up till now with limited succ ...
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 1

 TERMINÉ 
"Through combining basic pre-clinical and clinical research, network analysis and computational modelling, RESOLVE aims at resolving the disturbed dynamics and mechanisms underlying the high triglyceride (HTG) and low high-density lipoprotein cholesterol (HDL-C) phenotype and insulin resistance in patients with metabolic syndrome (MetS) and its associated co-morbidities (cardiovascular disease, CV ...
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 14

 TERMINÉ 
... specific application areas, modeling tools will be developed that allow quantitative analysis and prediction of conformational stabilities for modular protein switches. The availability of these robust and generally applicable engineering strategies will proof beneficial to many areas of life sciences, providing essential tools for intracellular imaging, synthetic biology, and molecular diagnosti ...
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 1

 TERMINÉ 
A spearhead function that lies within the promise of MNBS technologies is the rapid and sensitive detection of biomarker molecules in raw biological samples. However, it has been very difficult to realize the promise due to two key challenges:the signal-over-background challenge, i.e. many biomarkers have very low concentrations and real-life biological samples generate very high background signal ...
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 7

 TERMINÉ 
Description Improving the treatment of lower back painThe MySpine project aims to improve the treatment of lower back pain. Nowadays treatment and prognosis of spinal disc degeneration are still based on trial and error decisions from the surgeon, leading to numerous post treatment complications and eventual morbidity. MySpine is working ...
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 9

 TERMINÉ 
... synthetic chemistry with the spectrum of micro- and molecular biology techniques, thus important challenges in medicine can be addressed in revolutionary new ways. This innovative methodology allows problems associated with studying diseases and designing novel drug-like molecules to be tackled in a unique approach. A recent example is the combination of synthetic carbohydrate chemistry with paras ...
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 1

 TERMINÉ 
Disorders arising from degeneration of the intervertebral disc are an enormous clinical and financial burden on European societies. Most of the burden arises from 10% of patients who become chronically disabled. Any factor which will improve treatment of back pain sufferers or prevent development of chronic disability would have an important impact both on society and in improving quality of life ...
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 10

 TERMINÉ 

Osteoporotic Virtual Physiological Human (VPHOP)

Date du début: 1 sept. 2008, Date de fin: 31 oct. 2012,

... entional diagnostic imaging methods that makes it possible, in a clinical setting, to predict for each patient the strength of his/her bones, how this strength is likely to change over time, and the probability that the he/she will overload his/her bones during daily life. With these three predictions, the evaluation of the absolute risk of bone fracture will be much more accurate than any predic ...
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 21

 TERMINÉ 

Image-controlled Ultrasound-induced Drug Delivery (SonoDrugs)

Date du début: 1 nov. 2008, Date de fin: 31 oct. 2012,

The demographic changes in Europe towards an aging society will coincide with increasing morbidity of the population. European citizens need improved access to state-of-the-art medical care especially in oncology and cardiology, while keeping expenditures on healthcare affordable. New therapeutic options such as externally triggered local drug release at the diseased area hold promise to solve urg ...
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 18