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Plus de 40 projets européens trouvés

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 TERMINÉ 

Translating neuroimaging findings from research into clinical practice (PSYSCAN)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2020,

Abstract 9Neuroimaging (NI) has enormous potential to improve the clinical care of patients with psychiatric disorders, but has yet to deliver. The PSYSCAN project will address this issue directly by developing a NI-based tool that will help clinicians resolve key clinical issues in the management of patients with psychotic disorders. Clinicians will use the tool to assess patients with a standard ...
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 24

 TERMINÉ 

The Developing Human Connectome Project (dHCP)

Date du début: 1 sept. 2013, Date de fin: 31 août 2019,

Few advances in neuroscience could have as much impact as a precise global description of human brain connectivity and its variability. Understanding this ‘connectome’ in detail will provide insights into fundamental neural processes and intractable neuropsychiatric diseases.The connectome can be studied at millimetre scale in humans by neuroimaging, particularly diffusion and functional connectiv ...
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 4

 TERMINÉ 

10/66 ten years on – monitoring and improving health expectancy by targeting frailty among older people in middle income countries (LIFE2YEARS1066)

Date du début: 1 août 2014, Date de fin: 31 juil. 2019,

"Population ageing and the transition from infectious to chronic diseases is occurring more rapidly in middle than it did in high income countries. Chronic diseases are already leading causes of death in all regions, but the focus on preventing premature mortality neglects the societal impact of the emerging epidemic on disability/dependence, particularly in older people. The PIs 12 year program o ...
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 1

 TERMINÉ 

Aggression in Children: Unraveling gene-environment interplay to inform Treatment and InterventiON strateg (ACTION)

Date du début: 1 juin 2014, Date de fin: 31 mai 2019,

Aggression inflicts a huge personal, psychological and financial burden on affected individuals, their relatives, and society at large. Despite large scientific, preventive, and treatment investments, no decrease in aggressive behavior is seen. This calls for a shift to new approaches. By capitalising on comprehensive longitudinal cohorts, recent advances in genetic, biological, epidemiological, a ...
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 12

 TERMINÉ 

Ego-media: The impact of new media on forms and practices of self-presentation (EGO-MEDIA)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,

Ego-media: The impact of new media on forms and practices of self-presentationThis project aims to study the impact of new media on autobiographical narratives: an impact increasing as habits and practices of self-presentation evolve rapidly in response to constantly fast-changing technology. It will analyse the range of ways in which autobiographical forms and discursive practices are being trans ...
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 1

 TERMINÉ 

Multidisciplinary Approaches to Translational Research In Conduct Syndromes (MATRICS)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,

Conduct Disorder (CD) is the key paediatric disorder characterized by severe aggression. It is heterogeneous, and our understanding of the neurobiology to subtype aggression is limited. MATRICS is a multidisciplinary consortium of academic partners and SMEs that focuses on the subtyping of aggression both within CD and of the broader cross-disorder trait of aggression. MATRICS will test the hypoth ...
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 21

 TERMINÉ 

Nodal Lines (NODAL)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

"First observed by the physicist and musician Ernst Chladni in the 18th century, the nodal lines(also referred to as the Chladni Plates or Chladni Modes) appear in many problems in engineering, physics and natural sciences. Nodal lines describe sets that remain stationary during membrane vibrations, hence their importance in such diverse areas as musical instruments industry, mechanical structures ...
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 1

 TERMINÉ 

How Membrane Physical Properties and Cortical Actin Regulate Protein Interactions During T Cell Signalling (MemRegPro)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

The overall aim of this project is to identify key biophysical mechanisms that control the spatial arrangement of signalling proteins and membrane lipids in the regulation of T cell activation. During an immune response, T cells are activated in response to antigenic peptides in a process that requires the formation of multi-molecular signalling complexes. It is known that many T cell signalling p ...
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 1

 TERMINÉ 

THE MILESTONE PROJECT: Managing the Link and Strengthening Transition from Child to Adult Mental Health Care (MILESTONE)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

Transition to adulthood is the period of onset of most of the serious mental disorders that disable or kill in adult life. Current service configuration of distinct Child and Adolescent Mental Health (CAMHS) and Adult Mental Health (AMHS) Services is considered the weakest link where the care pathway should be most robust. Transition-related discontinuity of care is a major socioeconomic and socie ...
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 14

 TERMINÉ 

Virtual Centre of Excellence for Research in Violent Online Political Extremism (VOX-Pol)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,

VOX-Pol is a 60-month, €5+ million project that integrates the world’s leading researchers and research groups in Violent Online Political Extremism (VOPE), to include those researching the intersection of terrorism and the Internet (incl. violent jihadists, violent separatists, etc.), the online activities of the extreme Right, the potential for violent online radicalisation, etc., in order to:1. ...
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 9

 TERMINÉ 

SOURCE - Virtual centre of excellence for research support and coordination on societal security (SOURCE)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,

The aim of the SOURCE Network of Excellence is to create a robust and sustainable virtual centre of excellence capable of exploring and advancing societal issues in security research and development. The SOURCE Network of Excellence is built upon five types of activities: networking activities, research, information gathering, education and training, and knowledge-sharing. These five areas togethe ...
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 14

 TERMINÉ 

Adolescent Precursors to Psychiatric Disorders – Learing from Analysis of User-Service Engagement (APPLAUSE)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,

APPLAUSE’s aim is to produce a body of evidence that illustrates how young people with mental health problems currently interact with both formal mental health services and informal social and familial support structures. Careful analysis of data gathered in the UK and Brazil will allow formulation of globally relevant insights into mental health care delivery for young people, which will be prese ...
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 2

 TERMINÉ 

Mechanisms of homeostatic plasticity in the intact mouse visual cortex (HOMEOSTASIS_IN_VIVO)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2018,

Changes in input lead to changes of synaptic circuits in the brain via a combination of synapse specific Hebbian plasticity and cell-wide homeostatic plasticity. While Hebbian plasticity has been well studied, there are still a number of outstanding fundamental questions related to homeostatic plasticity. We have previously developed a paradigm that allows us to monitor changes to multiple homeost ...
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 2

 TERMINÉ 

Redox sensing and signalling in cardiovascular health and disease (CARDIOREDOX)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,

"We want to determine how oxidants are sensed and transduced into a biological effect within the cardiovascular system. The proposed work will focus on thiol-based redox sensors, defining their role in heart and blood vessel function during health and disease. Although this laboratory has studied the molecular basis of redox signaling for more than a decade, the subject is still in its relative in ...
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 1

 TERMINÉ 

Complex Synthetic Mimics of the Cell Membrane (COSMIC)

Date du début: 1 févr. 2013, Date de fin: 31 oct. 2018,

I propose to bridge the gap between simple in vitro measurements of biological processes, and the complexities of the cellular environment. This requires reduced in vitro systems that are sufficiently complex to reproduce the subtleties of the in vivo biological phenomenon, but sufficiently controllable to test how quantitative changes in a particular property affects function. The challenge is to ...
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 2

 TERMINÉ 

Aggression subtyping for improved insight and treatment innovation in psychiatric disorders (AGGRESSOTYPE)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Aggression is a basic physiological trait with important roles throughout evolution, both in defence and predation. When expressed in humans in the wrong context, aggression leads to maladjustment, social impairment and crime. Despite this, knowledge about aggression aetiology is limited and current treatment strategies are insufficient. Contingent to a subdivision into impulsive and instrumental ...
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 27

 TERMINÉ 

Development and Epilepsy - Strategies for Innovative Research to improve diagnosis, prevention and treatment in children with difficult to treat Epilepsy (DESIRE)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

DESIRE will focus on epileptogenic developmental disorders EDD, i.e. early onset epilepsies whose origin is closely related to developmental brain processes. A major cause of EDD are malformations of cortical development (MCD), either macroscopic or subtle. EDD are often manifested as epileptic encephalopathies (EE), i.e. conditions in which epileptic activity itself may contribute to severe cogni ...
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 29

 TERMINÉ 

Hepatic and Cardiac Toxicity Systems modelling (HECATOS)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

HeCaToS aims at developing integrative in silico tools for predicting human liver and heart toxicity. The objective is to develop an integrated modeling framework, by combining advances in computational chemistry and systems toxicology, for modelling toxic perturbations in liver and heart across multiple scales. This framework will include vertical integrations of representations from drug(metabol ...
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 14

 TERMINÉ 

Health and Environment-wide Associations based on Large population Surveys (HEALS)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

Assessing individual exposure to environmental stressors and predicting health outcomes implies that both environmental exposures and epi/genetic variations are reliably measured simultaneously. HEALS (Health and Environment-wide Associations based on Large population Surveys) brings together in an innovative approach a comprehensive array of novel technologies, data analysis and modeling tools th ...
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 37

 TERMINÉ 

Multi-dimensional omics approach to stratification of patients with low back pain (PAIN-OMICS)

Date du début: 1 sept. 2013, Date de fin: 31 août 2018,

"Pain-OMICS is a multidisciplinary consortium of leading clinical, academic and SME researchers in pain and different omics technologies. Genome-wide association studies identified a number of loci associated with pain, but the level of knowledge about underlying mechanisms of different pain syndromes as well as individual variation in the disease course remains inadequate. Pain-OMICS will capital ...
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 11

 TERMINÉ 

Modulation of a novel population of immune suppressive tumoural macrophages and the therapeutic vaccination of cancer (MacTherVac)

Date du début: 1 sept. 2013, Date de fin: 31 août 2018,

The therapeutic vaccination against breast cancer, and more widely all solid tumours, has largely been ineffective in clinical trials. This failure has been attributed to ‘immune editing’ of the cancerous cells, or to suppression of T cell functions within the tumour. In relation to the later, we have identified a novel population of tumoural macrophages, marked by the expression of fibroblast act ...
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 1

 TERMINÉ 

Beyond Enemy Lines: Literature and Film in the British and American Zones of Occupied Germany, 1945-1949 (BeyondEnemyLines)

Date du début: 1 sept. 2013, Date de fin: 31 août 2018,

This project investigates the cross-fertilisation of Anglo/American and German literature and film during the Allied Occupation of Germany. It will be the first study to survey the cultural landscape of the British and American zones of Occupied Germany in any detail. By doing so it will offer a new interpretative framework for postwar culture, in particular in three areas: the history of the Alli ...
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 1

 TERMINÉ 

Evaluation Practices in Financial Markets (EPIFM)

Date du début: 1 sept. 2012, Date de fin: 31 août 2018,

EPIFM will be a social-science (rather than, as conventionally, an economic) investigation, by a team bridging science and technology studies (STS), sociology and politics, of how professional participants in financial markets evaluate financial instruments such as shares and bonds. These evaluation practices are crucial to the operation of financial markets (they help determine the activities to ...
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 3

 TERMINÉ 

Modern Moves: Kinetic Transnationalism and Afro-Diasporic Rhythm Cultures (MODERNMOVES)

Date du début: 1 juin 2013, Date de fin: 31 mai 2018,

"The movement of Africans and Europeans to the Americas through expansionism, colonialism, and slavery also brought to the New World African percussive rhythms and European musical instruments and courtly dances. This project investigates the social dances that evolved out of this encounter, and retained African rhythm structures and body movement in American and Caribbean diasporic spaces. Under ...
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 1

 TERMINÉ 

Music in London, 1800-1851 (Muslond)

Date du début: 1 mai 2013, Date de fin: 30 avr. 2018,

This project aims to construct a wide-ranging interdisciplinary history of music in London in the first half of the nineteenth century. It will be original in method and scope, will generate a series of book-length publications, and is intended to serve as a model for a new kind of music historiography. Past histories of Western music-making have mostly focussed on elite culture, and have tended t ...
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 1

 TERMINÉ 

Assembling biomembranes: fundamentals of membrane transporter folding and creation of synthetic modules (MEMSEMBLE)

Date du début: 1 mai 2012, Date de fin: 30 avr. 2018,

Self-assembly is a hallmark of Biology. We are far from a complete understanding of this natural assembly, which in turn limits our ability to mimic biological construction in the bioengineering of tuneable synthetic systems.This proposal addresses the major challenge of membrane protein folding. Here, I intend to make a step change to my pioneering biophysical studies and investigate co-translati ...
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 2

 TERMINÉ 

Frontiers in nanophotonics: integrated plasmonic metamaterials devices (iPLASMM)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2018,

Photonic methamaterials have unique optical properties not available in natural materials. The key question is how to integrate metamaterials within nanophotonics circuitry to harness all the advantages they offer in controlling light on the nanoscale. iPLANET will develop a plasmonic nanorod metamaterial platform for applications covering the entire spectral range from mid-IR through telecom to v ...
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 1

 TERMINÉ 

Mechanisms Underlying Treatment Responses in Psychosis (MUTRIPS)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2018,

"Psychotic symptoms (hallucinations and delusions) have been associated with a striatal hyperdopaminergic state.Less explored, but also implicated are functional abnormalities in cognitive control, particularly in the prefrontal cortex; and a functional and structural disconnectivity between this and other areas of the brain.Such a disconnectivity would explain the lack of coherent response to con ...
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 1

 TERMINÉ 

"Comparing policy framework, structure, effectiveness and cost-effectiveness of functional and integrated systems of mental health care" (COFI)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2018,

"Mental disorders affect 38.2% of the EU population. For reducing the associated burden, countries across Europe engage in costly re-organizations of mental health care systems. Reforms focus on one controversial core question: Should systems be functional or integrated? In functional systems, separate staff in different services are in charge of in- and out-patient care (to enhance specialization ...
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 7

 TERMINÉ 

Clearing Clutter Bit by Bit (SQUIRREL)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2018,

Clutter in an open world is a challenge for many aspects of robotic systems, especially for autonomous robots deployed in unstructured domestic settings, affecting navigation, manipulation, vision, human robot interaction and planning.SQUIRREL addresses these issues by actively controlling clutter and incrementally learning to extend the robot's capabilities while doing so. We term this the B3 (bi ...
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 10

 TERMINÉ 

European Medical Information Framework (EMIF)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

In response to the need to tackle increasingly complex medical research questions, a growing amount of human health data is being collected, either in routine Electronic Healthcare Record (EHR) databases, through research-driven cohort studies, in biobanks or related efforts. However, data sources are typically fragmented and contain information gaps which prevent their full exploitation. EMIF aim ...
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 64

 TERMINÉ 

Molecular Mechanisms of GABAergic synapse formation: spatial segregation in cortical inhibitory inputs (SYNAPDOMAIN)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

"Neuronal circuitries underlying the function of the mammalian cerebral cortex collectively constitute one of the most complex biological systems. As such, unraveling the mechanisms that control their development represents one of the most challenging questions in Science. Understanding this process is also an imperative need in biomedicine, because abnormal wiring is thought to cause severe neuro ...
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 2

 TERMINÉ 

Phase I/II ex vivo gene therapy clinical trial for recessive dystrophic epidermolysis bullosa using skin equivalent grafts genetically corrected with a COL7A1-encoding SIN retroviral vector (GENEGRAFT)

Date du début: 1 mars 2011, Date de fin: 31 déc. 2017,

RDEB is one of the most severe rare genetic skin diseases of children and adults characterized by skin blistering resulting from lack of expression of type VII collagen. There is no treatment for this life-threatening disease. In March 2009, we obtained the orphan drug designation for the Medicinal product: “Skin equivalent graft genetically corrected with a COL7A1-encoding SIN retroviral vecto ...
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 10

 TERMINÉ 

The Gauge/Gravity Duality and Geometry in String Theory (Gauge/Gravity)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

While the three sub-atomic forces are described by quantum mechanics, the fourth known force, gravity, is described by Einstein's theory of general relativity. These two very successful theories are incompatible, and understanding how to unify them in a single framework is an outstanding problem. String theory is the most prominent candidate for a unified theory of all forces of Nature. The most i ...
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 1

 TERMINÉ 

Preparing for Extreme And Rare events in coastaL regions (PEARL)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2017,

"Coastal floods are one of the most dangerous and harmful natural hazards affecting urban areas adjacent to shorelines. Rapid urbanisation combined with climate change and poor governance means a significant increase in the risk of local surface flooding coinciding with high water levels in rivers and high tide or storm surges from the sea, posing a greater risk of devastation to coastal communiti ...
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 26

 TERMINÉ 

"An Integrated Computer Modelling Framework for Subject-Specific Cardiovascular Simulation: Applications to Disease Research, Treatment Planning, and Medical Device Design" (INTEG-CV-SIM)

Date du début: 1 déc. 2012, Date de fin: 30 nov. 2017,

"Advances in numerical methods and three-dimensional imaging techniques have enabled the quantification of cardiovascular mechanics in subject-specific anatomic and physiologic models. Research efforts have been focused mainly on three areas: pathogenesis of vascular disease, development of medical devices, and virtual surgical planning. However, despite great initial promise, the actual use of pa ...
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 1

 TERMINÉ 

European Research Infrastructures for Poverty Related Diseases (EURIPRED)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,

HIV/AIDS, Tuberculosis (TB) and Malaria alone account for more than six million deaths worldwide every year. Despite substantial efforts made in recent years, Poverty Related Diseases are still spreading. New therapeutic interventions are therefore urgently required to combat Poverty Related Diseases. The existence of a well-developed HIV/TB/Malaria infrastructure presents a prime opportunity to a ...
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 18

 TERMINÉ 

Emerging mental health systems in low- and middle-income countries (EMERALD)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2017,

The objective of the EMERALD Project is to improve mental health outcomes by enhancing health system performance.The key issues addressed are: (i) adequate, fair & sustainable resourcing: using human, infrastructural, informational & financial resource inputs to effectively deliver better mental health services; (ii) integrated service provision: enhancing access to integrated community care; and ...
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 12

 TERMINÉ 

Personalized minimization of immunosuppression after solid organ transplantation by biomarker-driven stratification of patients to improve long-term outcome and health-economic data of transplantation (BIO-DrIM)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2017,

Organ transplantation has emerged as the “gold standard” therapy for end-stage organ failure. Incomplete control of chronic allograft injury but also the adverse effects of long-term immunosuppression (IS) continue to challenge the long-term success of transplantation. The paradigm is shifting from increasing “net”-IS by novel drugs to the concept of minimizing long-term IS as early as possible. H ...
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 17

 TERMINÉ 

Improving arm and hand function after stroke with clinically-relevant delivery of neurotrophin-3 to elderly disabled muscles: from rats to humans (StrokeTherapy)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2017,

Stroke disables millions worldwide and costs the EU €38 billion each year. Excitingly, my team has identified a clinically-feasible therapy for stroke which reverses disability in rats when given in a clinically-relevant time frame. Specifically, we have shown that the human growth factor neurotrophin 3 (NT3) promotes locomotor recovery and reverses sensory neglect in adult rats when infused into ...
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 1