Date du début: 1 janv. 2015,
Date de fin: 31 déc. 2021,
Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte ...
Date du début: 1 nov. 2012,
Date de fin: 30 avr. 2018,
DevelopAKUre is a proposal to fund the clinical development of an orphan designated drug, nitisinone, for the treatment of a rare Mendelian disease, Alkaptonuria (AKU). AKU is a genetic deficiency of homogentisic acid dioxygenase, causing high levels of homogentisic acid (HGA). Oxidation of HGA to pigment polymer, termed ochronosis, alters connective tissues. This leads to multisystemic damage dom ...
Date du début: 1 oct. 2012,
Date de fin: 30 sept. 2017,
"Chronic inflammatory diseases of joints are major causes of disability in the ageing population. Osteoarthritis (OA) is one of the most common types of arthritis and a major cause of pain and disability in older individuals. OA is expected to place a heavy burden on European healthcare systems, as European citizens grow older. Cartilage damage in OA is detected radiographically by decreases in jo ...
Date du début: 1 févr. 2012,
Date de fin: 31 janv. 2017,
The current test systems employed by Industry are poorly predictive for Drug induced liver injury (DILI). The ‘MIP-DILI’ project will address this situation by the development of innovative preclinical test systems which are both mechanism-based and of physiological, pharmacological and pathological relevance to DILI in humans. An iterative, tiered approach with respect to test compounds, test sys ...
Date du début: 1 janv. 2012,
Date de fin: 31 déc. 2016,
"The concept of THE GRAIL project is the creation of an in vivo, in situ structured bioactive, selectively porous, bioresorbable scaffold that locally regenerates intima growth after endovascular treatment of the obstructed arteries in patients with atherosclerosis. Arterial obstruction due to arteriosclerosis is the cause of a wide spectrum of diseases, disabilities and death, because of induced ...
Date du début: 1 mars 2012,
Date de fin: 30 juin 2016,
Diabetic retinopathy (DR), the leading cause of blindness among working-age individuals in developed countries has been classically considered to be a microcirculatory disease of the retina. However, there is growing evidence to suggest that retinal neurodegeneration is an early event in the pathogenesis of DR. For this reason, it is reasonable to hypothesize that therapeutic strategies based on n ...
Date du début: 1 oct. 2012,
Date de fin: 31 mars 2016,
"The objective of CHROMED project is to evaluate the impact of adopting a health and lifestyle status management system to support elderly patients with a combination of chronic diseases involving respiratory and cardiovascular systems. A large scale clinical trial will be implemented to develop and evaluate clinical protocols and organizational models based on the new technologies in order to imp ...
Date du début: 1 févr. 2010,
Date de fin: 31 juil. 2013,
The ARTIST project aims at exploring alternative routes towards long distance (above 10 nm) information transport and storage at the atomic and molecular scale. ARTIST suggests new solutions for optical and electrical addressing of molecules, efficient inter-molecular communication and compatible data storage. We will implement new concepts and methods for molecular electronics based on:Addressing ...
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