10 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Development of universal vaccinal dendritic cells lines for cancer treatment (PDCTherapy)
Date du début: 19 juil. 2010, Date de fin: 18 oct. 2011,
...ic setting to induce the activation and proliferation of specific efficient cytotoxic T lymphocytes in vitro (melanoma patients’ samples) and in vivo (preclinical humanized mouse model). Allogeneic PDCs therefore represents a new promising immunotherapeutic strategy to fight cancer. The project aims to create a set of universal “off-the-shelf” dendritic cell lines based on GEN2.2. The current stra ...
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1
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TERMINÉ
Closing in on Runx3 and CXCL4 to open novel avenues for therapeutic intervention in systemic sclerosis (CIRCUMVENT)
Date du début: 1 août 2012, Date de fin: 31 juil. 2017,
...d premature death.Over the past three years several crucial observations by my group changed the landscape of our thinking about the ethiopathogenesis of this disease. First, plasmacytoid dendritic (pDCs) cells were found to be extremely frequent in the circulation of SSc patients (1000-fold) compared with healthy individuals. In addition, we observed that pDCs from SSc patients are largely dedic ...
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1
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TERMINÉ
Role of plasmacytoid dendritic cells in the orchestration of in vivo immune responses (ORCHESTRATE)
Date du début: 1 déc. 2012, Date de fin: 30 nov. 2014,
"Plasmacytoid dendritic cells (pDCs) which are professional type I IFN producing cells modulate phenotype and function of conventional dendritic cells (cDCs) triggering maturation and enhancing priming of cytotoxic T lymphocytes (CTLs). It is widely accepted that type I IFNs offer a link between innate and adaptive immune responses, but there are contrasting data regarding their immunoregulatory e ...
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1
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TERMINÉ
Investigation of the cross-talk between innate and adaptive immunity (X-talk)
Date du début: 1 janv. 2014, Date de fin: 31 déc. 2017,
...nse, and adaptive immunity, responsible for memory. Recent evidence suggests that, in addition to their undisputed role in innate immunity, natural killer (NK) cells and plasmacytoid dendritic cells (pDCs) are important contributors to adaptive immune responses. Yet the mechanisms underlying these cellular interactions are still obscure.Lately, we could demonstrate a key role for NK cells in the i ...
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1
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TERMINÉ
The Expression of CXC chemokine ligand 4 in Systemic Sclerosis and its Role in the regulation of immune and fibrotic responses (EXCELSIOR)
Date du début: 1 mars 2014, Date de fin: 2 juil. 2016,
...ocates an important role of immune cells in the pathogenesis of this disease. In the last few years Prof. Radstake's has focused on immune cell subsets, in particular on plasmacytoid dendritic cells (pDCs), to identify their potential role in SSc. This has led to various landmark observations. Firstly, pDCs were found to secrete high amounts of specific chemokine-CXCL4. Secondly, CXCL4 was found t ...
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1
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TERMINÉ
Therapeutic approaches to enhance innate immunity against Tumors (TNT-TUMORS)
Date du début: 1 sept. 2016, Date de fin: 31 août 2021,
... patients shows that this is only the start to utilize the power of the immune system to fight cancer. An interesting approach is to harness innate immune cells, such as plasmacytoid dendritic cells (pDCs) and tumor-associated macrophages (TAM) to attack tumors and to enhance the effect of standard anti-cancer therapies. Recently, using mouse models we identified two independent mechanisms by whic ...
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1
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TERMINÉ
Development and implementation of masters programmes in food safety and the production and marketing of TRADitional food PROducts in Russia and Kazakhstan
Date du début: 1 déc. 2013,
...d Marketing of Traditional Food Products, and establish mechanisms to promote effective collaboration between universities and food industry professionals (e.g. Professional Development Centres PDCs). TradPro will thereby meet the demands of food producers, sellers, and consumers; strengthen relations between EU and RU-KZ universities; stimulate local economic development by providing new opportun ...
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19
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TERMINÉ
MASTER IN HIGHER EDUCATION MANAGEMENT: DEVELOPING LEADERS FOR MANAGING EDUCATIONAL TRANSFORMATION
Date du début: 15 oct. 2012,
...t;• introduction of a learning outcome approach to teaching, learning and student assessment methods;• enhancement of the institutional capacity to implement the new Master’s programme/PDCs (teaching and learning and management of the programme; as well as • promotion of a change dialogue between the education stakeholders thorough establishment of a Professional Association of Educationalists lea ...
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18
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TERMINÉ
... trial will be managed by MF & Partners Consulting, a training and business consultancy which already uses online technology in its training activities. The Slovak trial will be managed by PDCS, the partner responsible for the successful Slovak trial in SISINE. The trials will test the project in three distinct settings: high schools (in Italy), SMEs (in France) and the Public Administration (in S ...
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5
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TERMINÉ
Community building lab
Date du début: 1 oct. 2016, Date de fin: 31 juil. 2018,
The project aims to respond to the numerous initiatives of young people who are involved in building of communities, in the creation of an inclusive environment, engaging marginalized groups and actually volunteerin in the refugee crisis. In cooperation with experienced partner organizations from Slovakia, we project to offer innovative tools such as e-community, e-library, learning exchanges, cou ...
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